2009
DOI: 10.1016/j.nbd.2008.12.009
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Recovery of function in a myogenic mouse model of spinal bulbar muscular atrophy

Abstract: With this paper, we deliberately challenge the prevailing neurocentric theory of the etiology of spinal bulbar muscular atrophy (SBMA). We offer data supporting an alternative view that androgen receptor (AR) acts in skeletal muscles to cause the symptoms of SBMA. While SBMA has been linked to a CAG repeat expansion in the AR gene and mutant AR is presumed to act in motoneurons to cause SBMA, we find that over-expression of wild type AR solely in skeletal muscle fibers results in the same androgen-dependent di… Show more

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Cited by 44 publications
(69 citation statements)
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“…More direct evidence comes from studies of genetic manipulation of AR in myocytes. We find that HSA-AR rats and mice have increased RMR and ETC activity (Fernando et al 2010; Tables 1 and 2) and that HSA-AR mice have increased NADH/diaphorase staining (Monks et al 2007, Johansen et al 2009) and increased mitochondrial density, number, and/or size (Figs 1, 3, 4 and 6). Increases in oxidative metabolism of HSA-AR mice and rats are not secondary to increases in muscle mass, indicating hypermetabolism.…”
Section: Mitochondriamentioning
confidence: 79%
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“…More direct evidence comes from studies of genetic manipulation of AR in myocytes. We find that HSA-AR rats and mice have increased RMR and ETC activity (Fernando et al 2010; Tables 1 and 2) and that HSA-AR mice have increased NADH/diaphorase staining (Monks et al 2007, Johansen et al 2009) and increased mitochondrial density, number, and/or size (Figs 1, 3, 4 and 6). Increases in oxidative metabolism of HSA-AR mice and rats are not secondary to increases in muscle mass, indicating hypermetabolism.…”
Section: Mitochondriamentioning
confidence: 79%
“…However, the pathology of HSA-AR mice (Monks et al 2007, Johansen et al 2009) complicates this interpretation, raising the possibility that any changes seen are secondary to a pathological process. Although, we may be at least assured that these changes are independent of the most severe pathology (e.g.…”
Section: Discussionmentioning
confidence: 99%
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