2019
DOI: 10.1128/jcm.00849-19
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Recovery of Gram-Negative Bacteria from Aerobic Blood Culture Bottles Containing Antibiotic Binding Resins after Exposure to β-Lactam and Fluoroquinolone Concentrations

Abstract: Blood culture bottles containing antibiotic binding resins are routinely used to minimize artificial sterilization in the presence of antibiotics. However, the resin binding kinetics can differ between antibiotics and concentrations. This study assessed the impact of clinically meaningful peak, midpoint, and trough concentrations of meropenem, imipenem, cefepime, cefazolin, levofloxacin, and piperacillin-tazobactam on the recovery of Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae from resi… Show more

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Cited by 5 publications
(7 citation statements)
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“…1C). Similar observations have been made for cefepime in aerobic bottles containing proprietary resins with other organisms as well (10,11). In the aerobic bottles, these same isolates were not recovered in the presence of any clinically relevant cefepime concentrations (10).…”
Section: Discussionsupporting
confidence: 77%
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“…1C). Similar observations have been made for cefepime in aerobic bottles containing proprietary resins with other organisms as well (10,11). In the aerobic bottles, these same isolates were not recovered in the presence of any clinically relevant cefepime concentrations (10).…”
Section: Discussionsupporting
confidence: 77%
“…As such, recovery of bacteria depends not only on the actual plasma concentration at the time of culture collection relative to the MIC, but also the specific antibiotic itself, the inoculum in the bloodstream, the type of bottle used (i.e., media composition), and other factors such as blood volume collected, temperature stability, and length of time prior to incubation. Our lab has also assessed recovery of these same E. coli and K. pneumoniae strains in BacT/Alert FA Plus and Bactec aerobic/F blood culture bottles, both aerobic resin-containing bottles (10). Certain antibiotic concentration-bacteria combinations, notably with the carbapenems, resulted in improved recovery in the anaerobic bottles.…”
Section: Discussionmentioning
confidence: 99%
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