The association between decreased hand grip strength and hip fracture in older people: a systematic review ABSTRACT Hip fractures are a global concern, resulting in poor outcomes and high health care costs. They mostly affect people >80 years. Hip fractures are influenced by various (modifiable) risk factors. Emerging evidence suggests hand grip strength (HGS) to be one of several useful tools to identify hip fracture risk. This is the first systematic review that aims to assess the evidence underlying the relationship between hip fracture incidence and HGS. Eleven studies were selected for this review (six case-control and five cohort studies), comprising 21197 participants. Where reported, HGS was significantly decreased in individuals with a hip fracture near the time of injury as compared to controls (p<0.001); HGS was associated with increased hip fracture risk in all included studies. Meta-analysis was not possible. All studies included in this systematic review confirmed a relationship between decreased HGS and hip fracture incidence. We were not able to quantify the strength of this relationship, due to the heterogeneity of the included studies. HGS merits further investigation as a useful tool for identifying individuals that might be at elevated risk for sustaining a hip fracture. Key words: Hand grip strength, hip fracture, proximal femur fracture, frailty, risk factor 1. Introduction Low impact fractures of the proximal femur (hip fractures) are a major worldwide public health concern (Hernlund et al., 2013; Kanis et al., 2012; The World Bank, 2015). They mostly occur in people older than 80 years (Kistler et al., 2015). As the population ages, hip fractures are predicted to increase by 35% between 2012 and 2022; the annual cost will rise to $1.27 billion in Australia alone (Watts et al., 2013). The current annual hospital cost of hip fractures in the UK has been estimated at £1.1 billion (Leal et al., 2016). Thus, it is vital to further improve fracture prevention strategies, not only to decrease health care costs, but also to reduce devastating outcomes such as morbidity, disability, dependency, and poor quality of life (Griffin et al., 2015;Parker, 2016). Many, often modifiable, risk factors need to be considered for hip fracture prevention. Osteoporosis (Kanis, 1994) and falls (Jarvinen et al., 2008) are recognized risk factors for sustaining a hip fracture. Other factors include, but are not limited to, sarcopenia (Oliveira and Vaz, 2015), muscle weakness, physical inactivity, impaired cognition, impaired vision, and chronic health conditions (Marks, 2010). The current gold standard screening tool to assist in identifying those most at risk of hip fracture is the Fracture Risk Assessment Tool (FRAX®). FRAX is based on 12 variables: age, sex, weight, height, previous fracture, parent fractured hip, current smoking, glucocorticoids, rheumatoid arthritis, secondary osteoporosis, alcohol (three or more units/day), and femoral neck bone mineral density (BMD) (The University of Sheffield, 2011). Lo...