Recovery of itaconic acid from supersaturated waste fermentation liquor

Xiaoxian, Zhang; Ma, Fang; Lee, Dong Hoon

doi:10.1016/j.jtice.2009.04.007

Cited by 18 publications

(11 citation statements)

References 5 publications

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“…The experiments in fixed bed column were performed to remove IA from aqueous solution with a concentration of 52.0 g·L –1 and an initial pH 3.85. This was made to simulate the values of pH and IA concentration expected in a fermented broth, besides maintaining the pH close to p K a 1 (found to be more adequate for adsorption, as explained in the results). , The schematic diagram of the experimental setup is shown in Figure . A glass column with an internal diameter of 1.0 cm was used as fixed bed column.…”

Section: Methodsmentioning

confidence: 99%

Separation of Itaconic Acid from Aqueous Solution onto Ion-Exchange Resins

et al. 2015

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Itaconic acid (IA) is an unsaturated diacid, a promising compound that might replace part of the petrochemical-based monomers, such as acrylic acid, as a building block for polymers. Recent developments in biotechnology allow the efficient production of IA through fermentation processes. However, further enhancements are necessary in the downstream (recovery) of the product. This investigation examined the separation of IA by adsorption from aqueous solutions, using two types of commercial, strongly basic ion-exchange resins: Purolite A-500P and PFA-300. To evaluate the separation process, the following parameters were tested: pH (from 3.03 to 6.33), temperature (from 10 to 50 °C), and IA concentration (from 0.41 to 6.50 g·L–1). The Freundlich and Langmuir isotherms were shown to be good fits to the experimental data, and the adsorption kinetics for IA was found to follow a pseudo-second-order (PSO) model. After batch tests, continuous adsorption experiments were carried out using a fixed bed column, and a simplified mathematical model was developed and evaluated in order to determine the adsorption parameters. The experimental data obtained from the column tests were aligned with those obtained from the isotherms and batch simulations with PSO. The resin PFA-300 proved to be more efficient for IA recovery through adsorption, with a maximum capacity of 0.154 gIA.gresin –1 when compared to the resin A-500P, with a maximum capacity of 0.097 gIA.gresin –1. Both resins have high affinity for the solute, being half-saturated with equilibrium concentrations below 0.25 g·L–1 of acid.

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Section: Methodsmentioning

confidence: 99%

Separation of Itaconic Acid from Aqueous Solution onto Ion-Exchange Resins

et al. 2015

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“…It has two pK a values of 3.84 and 5.55. IA produced via fermentation of glucose is separated from the fermentation broth by filtration, evaporation, and crystallization [103]. Industrial grade IA product is obtained by first removing the mycelium and solids from the broth with filtration, then the filtrate is evaporated at sufficiently acidic conditions to remove excess water, and the products cooled to 4 °C for crystallization [58].…”

Section: Downstream Processing and Recovery Of Itaconic Acidmentioning

confidence: 99%

Emerging biotechnologies for production of itaconic acid and its applications as a platform chemical

Saha¹

2017

Journal of Industrial Microbiology and Biotechnology

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Recently, itaconic acid (IA), an unsaturated C5-dicarboxylic acid, has attracted much attention as a biobased building block chemical. It is produced industrially (>80 g L) from glucose by fermentation with Aspergillus terreus. The titer is low compared with citric acid production (>200 g L). This review summarizes the latest progress on enhancing the yield and productivity of IA production. IA biosynthesis involves the decarboxylation of the TCA cycle intermediate cis-aconitate through the action of cis-aconitate decarboxylase (CAD) enzyme encoded by the CadA gene in A. terreus. A number of recombinant microorganisms have been developed in an effort to overproduce it. IA is used as a monomer for production of superabsorbent polymer, resins, plastics, paints, and synthetic fibers. Its applications as a platform chemical are highlighted. It has a strong potential to replace petroleum-based methylacrylic acid in industry which will create a huge market for IA.

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“…It was widely used as an important precursor to synthesis pharmaceuticals, resins, adhesives, plasticizers, coatings, deodorants, herbicides, and surfactants [115][116][117]. IA has conjugated double bonds and two carboxyl groups according to its structure which can be used as co-monomer with acrylamide or self-polymerized to polyitaconic acid (PIA) [115].…”

Section: Itaconic Acidmentioning

confidence: 99%

Combining Bio- and Chemo-catalysis for the Sustainable Production of Chemicals

Liu

Lorenzini

Marr

2015

Sustainable Production of Bulk Chemicals

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Biomass has the potential to serve as a sustainable source of energy and organic carbon for our industrial society. The focus of this chapter is to provide a survey of different strategies to achieve chemical catalytic conversion of biomass-derived oxygenated feedstocks to value-added chemicals and fuels. The key reactions involved in the processing of biomass are hydrolysis, dehydration, isomerization, aldol condensation, reforming, hydrogenation/hydrogenolysis, and oxidation. Here, a few specific examples, namely efficient hydrolysis of cellulose over novel solid acids and synthesis of polyols by hydrogenation/hydrogenolysis of cellulose and sugar have been chosen for this review. Further, the selective conversion of platform molecules, such as furan, HMF, and biogenic carboxylic acids into intermediates, specialties, and fine chemicals has been considered. While many challenges are involved in biomass processing, understanding of fundamental reaction chemistry for different types of reactions can lead to the development of new approaches for specific processes.

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Recovery of itaconic acid from supersaturated waste fermentation liquor

Cited by 18 publications

References 5 publications

Separation of Itaconic Acid from Aqueous Solution onto Ion-Exchange Resins

Separation of Itaconic Acid from Aqueous Solution onto Ion-Exchange Resins

Emerging biotechnologies for production of itaconic acid and its applications as a platform chemical

Combining Bio- and Chemo-catalysis for the Sustainable Production of Chemicals

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