Recovery of Neurologic Function Following Nontraumatic Spinal Cord Lesions in Israel

Catz, Amiram; Goldin, Diana; Fishel, B; Ronen, Jacob; Bluvshtein, Vadim; Gelernter, Ilana

doi:10.1097/01.brs.0000142008.49907.c7

Cited by 51 publications

(51 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The substantial similarity between the two groups in both AIS and motor scores improvement is particularly noteworthy. In a large retrospective study involving 1085 non-traumatic patients and 250 traumatic ones, Catz et al 7 found a better prognosis for neurological recovery (evaluated as AIS impairment increase) in non-traumatic patients. This study do not confirm this finding.…”

Section: Discussionmentioning

confidence: 99%

“…However, in spite of the high incidence of non-traumatic lesions, which is considered to vary between 25 and 80% of the total admission for spinal cord injuries, there are still few studies on the influence of different etiologies (namely traumatic vs non-traumatic) on SCL outcome; [5][6][7][8][9][10][11] this is probably due to the different features of the two populations with regard to age, lesion severity and lesion to admission time (LTA), which are wellknown prognostic factors: 5 therefore, the two groups of patients are poorly comparable.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Traumatic and non-traumatic spinal cord lesions: an Italian comparison of neurological and functional outcomes

et al. 2010

View full text Add to dashboard Cite

Study design: Retrospective study. Objective: To compare the rehabilitation outcomes of non-traumatic and traumatic spinal cord injury patients. Setting: Spinal cord unit of a rehabilitation hospital in Italy. Patients and methods: In total, 380 patients at first rehabilitation stay after the lesion (144 traumatic patients and 236 non-traumatic patients; 244 men and 136 women; mean age 46.1±19.9 years; mean lesion to admission time 49.6 ± 39.8 days). Interventions: Not applicable. Measures: American Spinal Injury Association standards; Barthel index (BI), Rivermead mobility index and walking index for spinal cord injury. Statistical analysis: Poisson regression models with relative risks and 95% confidence intervals adjusted for the following confounders: age, sex, lesion level and Asia impairment. Models were stratified by age because a strong interaction between different variables and age was found. Results: Traumatic and non-traumatic populations showed several significant differences with regard to age, level and severity of lesion. When adjusted for these factors patients with traumatic injuries showed a significantly lower BI score at admission and significantly better improvement in the BI score by discharge. The two populations were discharged with similar functional outcome. No significant differences were found with regard to the others outcomes. Conclusions:In clinically stable patients, spinal cord injury etiology does not seem to affect the rehabilitative prognosis. At admission, traumatic patients show lower autonomy in daily life activities, probably because of the associated lesions that these patients often have. At discharge, traumatic and non-traumatic spinal cord lesion patients achieved similar results with regard to neurological and functional improvement.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Traumatic and non-traumatic spinal cord lesions: an Italian comparison of neurological and functional outcomes

et al. 2010

View full text Add to dashboard Cite

show abstract

“…[2][3][4][5][6][7][8][9][10][11][12] Most such studies, however, examined metastatic spinal cord compression only, and although they have demonstrated the benefits of rehabilitation in neoplastic patients with regard to pain, independence, prevention of complications and survival, they failed to make comparisons with traumatic SCI (TSCI) patients. [5][6][7][9][10][11][12] Thus, few studies have compared the outcomes of NSCI and TSCI patients, likely because of differences in prognostic factors (age, lesion severity and level, and lesion-to-rehabilitation hospital admission time) between these groups that render them incomparable.…”

Section: Introductionmentioning

confidence: 99%

“…Catz 8 observed that the odds of any neurological recovery and functional neurological recovery are significantly higher in patients with neoplastic disease than in patients with traumatic lesions. The studies that we have discussed, however, were conducted in completely different settings from those of the present study, particularly with regard to the length of rehabilitation.…”

Section: Introductionmentioning

confidence: 99%

Neoplastic myelopathies and traumatic spinal cord lesions: an Italian comparison of functional and neurological outcomes

et al. 2011

View full text Add to dashboard Cite

Background: Although neoplastic spinal cord injuries (NSCIs) constitute B25% of all non-traumatic spinal cord lesions, patients with such pathologies are seldom, if ever, admitted to specialized centers; further, their rehabilitation typically is short because of the perception that rehabilitation prolongs hospital stays unnecessarily and is reserved only for patients with very good prognoses. Study design: This study is a retrospective analysis. Objective: The objective of this study is to evaluate the neurological and functional outcomes of patients with NSCIs compared with those of patients with traumatic spinal cord injury (TSCI). Methods: We evaluated 208 patients with TSCIs and 63 with NSCIs; using a matching cohorts procedure, 43 comparable couples were selected from each group. The measures used to assess these patients were the American Spinal Injury Association standards, the Barthel Index (BI), the Rivermead Mobility Index and the Walking Index for Spinal Cord Injury. Results: In the general population, NSCI patients are older and have longer lesion-to-admission times and more incomplete lesions than TSCI patients. Therefore, the functional status at admission and outcomes differed between the groups. In the matching cohorts, TSCI patients had lower BI scores at admission than NSCI subjects. At discharge, the two groups had comparable functional outcomes. Neurological status was similar at admission and at discharge. Conclusions: Although they had slightly disparate functional levels at admission, NSCI and TSCI patients had the same outcomes at discharge. Our data suggest that in a selected cohort of NSCI patients, rehabilitation is as successful as that in TSCI subjects and allows most patients to be discharged instead of being institutionalized.

show abstract

“…66,67 Thus, it is well recognised that there is substantial improvement in clinical signs in many human patients that suffer incomplete SCI, [68][69][70] which can, indeed, complicate analysis of clinical trials of novel therapeutic interventions. 71,72 However, in common with human SCI patients, there is a subpopulation of affected dogs in which recovery is incomplete or does not occur at all; these affected dogs can be identified with reasonable certainty at an early stage after injury because they lose all sensory and motor function in the hindquarters and pelvic limbs.…”

Section: Treatment and Prognosismentioning

confidence: 99%

Clinical canine spinal cord injury provides an opportunity to examine the issues in translating laboratory techniques into practical therapy

et al. 2006

View full text Add to dashboard Cite

Study design: Review. Objectives: To highlight the value of investigating the effects of putative therapeutic interventions in clinical spinal cord injury (SCI) in domestic dogs. Setting: England, UK. Methods: Many experimental interventions in laboratory rodents have been shown to ameliorate the functional deficits caused by SCI; the challenge now is to determine whether they can be translated into useful clinical techniques. Important differences between clinical SCI in human patients and that in laboratory rodents are in the size of the spinal cord and heterogeneity of injury severity. A further key issue is whether the statistical difference in outcome in the laboratory will translate into a useful difference in clinical outcome. Here, we stress the value of investigating the effects of putative therapies in clinical SCI in domestic dogs. The causes of injury, ability to categorise the severity and methods available to measure outcome are very similar between canine and human patients. Furthermore, postmortem tissue more rapidly becomes available from dogs because of their short lifespan than from human patients. Results: The role that investigation of canine SCI might play is illustrated by our preliminary trials on intraspinal transplantation of olfactory glial cells for severe SCI. Conclusions: This canine translational model provides a means of 'filtering' putative treatments before human application.

show abstract

Recovery of Neurologic Function Following Nontraumatic Spinal Cord Lesions in Israel

Abstract: The prognosis for neurologic recovery is affected mainly by SCL severity and etiology, and is usually better in NTSCLs than in TSCLs.

Cited by 51 publications

References 13 publications

Traumatic and non-traumatic spinal cord lesions: an Italian comparison of neurological and functional outcomes

Traumatic and non-traumatic spinal cord lesions: an Italian comparison of neurological and functional outcomes

Neoplastic myelopathies and traumatic spinal cord lesions: an Italian comparison of functional and neurological outcomes

Clinical canine spinal cord injury provides an opportunity to examine the issues in translating laboratory techniques into practical therapy

Contact Info

Product

Resources

About