Recovery of neutrophil functions by transfer factor therapy in Wiskott-Aldrich syndrome

Abstract

[Summary] Granulocyte functions were studied in a case of Wiskott-Aldrich syndrome. In the agarose plate, granulocytes of this patient were shown to have moderately decreased responses in chemotaxis induced by N-formyl-methionyl-leucyl-phenylalanine (FMLP) and zymosanactivated human serum (ZAS), whereas they were shown to have a normal capacity of random migration. Phagocytosis and superoxide production by neutrophils were within normal limits.Chemotaxis of neutrophils in this patient was improved by transfer factor therapy. Clinical improvement of patients with Wiskott-Aldrich syndrome treated by transfer factor may be due to recovery of granulocyte functions.