Recovery of Oplopanax horridus (Sm.) Miq., an Important Ethnobotanical Resource, after Clearcut Logging in Northwestern British Columbia

Burton, Carla M.; Burton, Philip J.

doi:10.17348/era.14.0.001-015

Cited by 3 publications

(1 citation statement)

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“…Compared to few biological activity report of the leaves, the extracts of the stem and berries have only been screened for their antiproliferation effects of four human cancer cell lines (SW-480, HCT-116, HT-29, MCF-7, and NSCLC)[ 19 ]. Meanwhile, the root has been researched on its antibacterial, antifungal, antidiabetes, and anticancer effects [ 2 , 34 ]. In the past decade, although no record was found that any part of O. horridus was used to cure cancer in the long history, the extracts and compounds from the root of O. horridus exhibited their anticancer activities in recent investigations [ 2 , 4 ].…”

Section: Biological Activitiesmentioning

confidence: 99%

Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure‐Activity Relationship on Anticancer Effects

Wang

Yuan

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Oplopanax horridus, well-known as Devil's club, is probably the most important ethnobotanical to most indigenous people living in the Pacific Northwest of North America. Compared with the long history of traditional use and widespread distribution in North America, the study of O. horridus is relatively limited. In the past decade, some exciting advances have been presented on the phytochemistry and pharmacological diversity and structure-activity relationship on anticancer effects of O. horridus. To date, no systematic review has been drafted on the recent advances of O. horridus. In this review, the different phytochemicals in O. horridus are compiled, including purified compounds and volatile components. Animal and in vitro studies are also described and discussed. Especially, the potential structural-activity relationship of polyynes on anticancer effects is highlighted. This review aimed to provide comprehensive and useful information for researching O. horridus and finding potential agents in drug discovery.

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