Recovery of Ovulatory Menstrual Cycles under Hydrocortisone in Two Amenorrheic Women with Isolated Corticotropin Deficiency

Dewailly, Didier; Bourdelle-Hego, Marie-Françoise; Pouplard-Barthelaix, Annick; Fossati, P

doi:10.1159/000180958

Cited by 9 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypocortisolism itself, however, might negatively affect ovarian function. 12 Cortisol has also been demonstrated to stimulate the secretion of estrogen and progesterone by granulosa cells. 13…”

Section: Discussion Of Diagnosismentioning

confidence: 99%

A case of hyponatremia caused by central hypocortisolism

et al. 2007

View full text Add to dashboard Cite

show abstract

Section: Discussion Of Diagnosismentioning

confidence: 99%

A case of hyponatremia caused by central hypocortisolism

et al. 2007

View full text Add to dashboard Cite

show abstract

“…It presents clinically with a constellation of symptoms including tiredness, lethargy, postural hypotension, hypoglycaemic episodes and rarely adrenal crisis. It may be associated with several other features including mild hypogonadism and gynaecomastia (Shimatsu et al, 1987), thyroid abnormalities (Proto & Bertolissi, 1988), hyponatraemia, hyperprolactinaemia (Shimatsu et al, 1987;Shibutana, 1988) and anovulation (Dewailly et al, 1988) which reverse on cortisol replacement therapy. The diagnosis of this condition rests with establishing evidence of low cortisol production associated with a low or normal plasma ACTH with no other pituitary abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Isolated ACTH deficiency

Orme

Belchetz

1991

Clinical Endocrinology

View full text Add to dashboard Cite

Isolated ACTH deficiency is a rare disorder. We report four cases of this disease which presented to the Department of Endocrinology at Leeds General Infirmary over a one-year period. The diagnostic clinical and biochemical features of each case are discussed and the pertinent literature is reviewed. The clinical investigations vary somewhat between cases as the four patients presented in markedly different ways. Well validated dynamic endocrine investigations were employed including glucagon stimulation test (GST) and the corticotrophin releasing hormone (CRH) test (using 100 micrograms of human CRH with samples for ACTH and cortisol). Two patients probably had CRH deficiency and two had ACTH deficiency. All the cases are instructive, illustrating different features of this heterogeneous condition. We conclude that the diagnosis of this condition may be difficult due to the varied clinical presentation. We suggest that it is commoner than previously thought and that the precision of diagnosis can be improved using the CRH test.

show abstract

“…These effects of the HPA axis on the HPG axis are evident in the clinical state of ‘hypothalamic’ amenorrhoea associated with stress, depression, over exercise and eating disorders. Patients with undiagnosed ACTH deficiency may present with subfertility, with introduction of glucocorticoid therapy resuming an ovulatory menstrual cycle ( 96 , 97 ).…”

Section: Fertility In Adrenal Insufficiencymentioning

confidence: 99%

Fertility and pregnancy in adrenal insufficiency

Green,

Dineen,

O’Reilly

et al. 2023

Endocrine Connections

View full text Add to dashboard Cite

Despite the availability of adrenal hormone replacement therapy, patients with adrenal insufficiency can be affected by reduced fertility and parity. Patients with well managed adrenal insufficiency are expected to have uneventful pregnancies and favourable outcomes, but an increased risk of maternal and neonatal complications have been reported in some cases. Many physiological changes occur to the hypothalamic-pituitary-adrenal (HPA) axis during pregnancy, often making a new diagnosis and management of adrenal insufficiency challenging. The management of adrenal insufficiency also needs to reflect the physiologic changes of pregnancy, often requiring increased doses of glucocorticoid as pregnancy progresses and in some circumstances mineralocorticoid replacement (in primary adrenal insufficiency patients only), especially in the third trimester. To date, there are no prospective data guiding management of adrenal insufficiency in pregnancy. In this review, we focus on the impact of adrenal insufficiency on fertility and parity based on the aetiology of adrenal insufficiency and provide a practical approach to the management of patients with adrenal insufficiency before and during pregnancy.

show abstract

Recovery of Ovulatory Menstrual Cycles under Hydrocortisone in Two Amenorrheic Women with Isolated Corticotropin Deficiency

Cited by 9 publications

References 7 publications

A case of hyponatremia caused by central hypocortisolism

A case of hyponatremia caused by central hypocortisolism

Isolated ACTH deficiency

Fertility and pregnancy in adrenal insufficiency

Contact Info

Product

Resources

About