Recovery of Rickettsia Akari From the Korean Vole Microtus Fortis Pelliceus

Jackson, Elizabeth B.; Danauskas, Joseph X.; Coale, Mary C.; Smadel, Joseph E.

doi:10.1093/oxfordjournals.aje.a119903

Cited by 18 publications

(10 citation statements)

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“…Rickettsia akari , a mite-borne pathogen isolated from a rodent, was first reported in Korea in 1957 [37, 38]. Later, acute febrile patients tested positive by serological tests for R. japonica in 2004, 2005 and 2006 [9, 12, 13].…”

Section: Discussionmentioning

confidence: 99%

Molecular detection of Rickettsia species in ticks collected from the southwestern provinces of the Republic of Korea

et al. 2017

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BackgroundRickettsiae constitute a group of arthropod-borne, Gram-negative, obligate intracellular bacteria that are the causative agents of diseases ranging from mild to life threatening that impact on medical and veterinary health worldwide.MethodsA total of 6,484 ticks were collected by tick drag from June-October 2013 in the southwestern provinces of the Republic of Korea (ROK) (Jeollanam, n = 3,995; Jeollabuk, n = 680; Chungcheongnam, n = 1,478; and Chungcheongbuk, n = 331). Ticks were sorted into 311 pools according to species, collection site, and stage of development. DNA preparations of tick pools were assayed for rickettsiae by 17 kDa antigen gene and ompA nested PCR (nPCR) assays and the resulting amplicons sequenced to determine the identity and prevalence of spotted fever group rickettsiae (SFGR).Results Haemaphysalis longicornis (4,471; 52 adults, 123 nymphs and 4,296 larvae) were the most commonly collected ticks, followed by Haemaphysalis flava (1,582; 28 adults, 263 nymphs and 1,291 larvae), and Ixodes nipponensis (431; 25 adults, 5 nymphs and 401 larvae). The minimum field infection rate/100 ticks (assuming 1 positive tick/pool) was 0.93% for the 17 kDa antigen gene and 0.82% for the ompA nPCR assays. The partial 17 kDa antigen and ompA gene sequences from positive pools of H. longicornis were similar to: Rickettsia sp. HI550 (99.4–100%), Rickettsia sp. FUJ98 (99.3–100%), Rickettsia sp. HIR/D91 (99.3–100%), and R. japonica (99.7%). One sequence of the partial 17 kDa antigen gene for H. flava was similar to Rickettsia sp. 17kd-005 (99.7%), while seven sequences of the 17 kDa antigen gene obtained from I. nipponensis ticks were similar to R. monacensis IrR/Munich (98.7–100%) and Rickettsia sp. IRS3 (98.9%).ConclusionsSFG rickettsiae were detected in three species of ixodid ticks collected in the southwestern provinces of the ROK during 2013. A number of rickettsiae have been recently reported from ticks in Korea, some of which were identified as medically important. Results from this study and previous reports demonstrate the need to conduct longitudinal investigations to identify tick-borne rickettsiae and better understand their geographical distributions and potential impact on medical and veterinary health, in addition to risk communication and development of rickettsial disease prevention strategies.

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Section: Discussionmentioning

confidence: 99%

Molecular detection of Rickettsia species in ticks collected from the southwestern provinces of the Republic of Korea

et al. 2017

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“…The possibility exists, however, that other species of mites are also involved in the cycle ). Moreover, the pathogen was also isolated from commensal rats in Ukraine, from black rats (R. rattus), dusky-footed woodrats (Neotoma fuscipes) and deer mice (P. maniculatus) in the USA and from Korean reed voles (Microtus fortis) in Korea (Jackson et al 1957). This suggests that R. akari can adapt to other rodent hosts.…”

Section: Rickettsialpoxmentioning

confidence: 99%

Rodent-borne diseases and their risks for public health

Meerburg¹,

Singleton²,

Kijlstra³

2009

Critical Reviews in Microbiology

829

722

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Rodents are the most abundant and diversified order of living mammals in the world. Already since the Middle Ages we know that they can contribute to human disease, as black rats were associated with distribution of plague. However, also in modern times rodents form a threat for public health. In this review article a large number of pathogens that are directly or indirectly transmitted by rodents are described. Moreover, a simplified rodent disease model is discussed.

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“…Varicella and, in the early stages of rickettsialpox, other rickettsioses have to be considered in the differential diagnosis of this disease. The disease is still prevalent in New York City (40,134) and has also been found in the Ukraine (78), in Korea (133), and recently in Slovenia (196). Despite such a wide geographical spread, R. akari strains are very homogeneous; macrorestriction analysis of the U.S. and Ukrainian strains shows them to be indistinguishable (78).…”

Section: Previously Described Diseasesmentioning

confidence: 99%

Rickettsioses as paradigms of new or emerging infectious diseases

1997

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Rickettsioses are caused by species of Rickettsia, a genus comprising organisms characterized by their strictly intracellular location and their association with arthropods. Rickettsia species are difficult to cultivate in vitro and exhibit strong serological cross-reactions with each other. These technical difficulties long prohibited a detailed study of the rickettsiae, and it is only following the recent introduction of novel laboratory methods that progress in this field has been possible. In this review, we discuss the impact that these practical innovations have had on the study of rickettsiae. Prior to 1986, only eight rickettsioses were clinically recognized; however, in the last 10 years, an additional six have been discovered. We describe the different steps that resulted in the description of each new rickettsiosis and discuss the influence of factors as diverse as physicians' curiosity and the adoption of molecular biology-based identification in helping to recognize these new infections. We also assess the pathogenic potential of rickettsial strains that to date have been associated only with arthropods, and we discuss diseases of unknown etiology that may be rickettsioses.

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Recovery of Rickettsia Akari From the Korean Vole Microtus Fortis Pelliceus

Cited by 18 publications

References 0 publications

Molecular detection of Rickettsia species in ticks collected from the southwestern provinces of the Republic of Korea

Molecular detection of Rickettsia species in ticks collected from the southwestern provinces of the Republic of Korea

Rodent-borne diseases and their risks for public health

Rickettsioses as paradigms of new or emerging infectious diseases

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