Recovery of sensory function in skin deprived of its innervation by lesion of the peripheral nerve

Diamond, Jack; Foerster, Anne

doi:10.1016/0014-4886(92)90229-j

Cited by 22 publications

(15 citation statements)

References 18 publications

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“…The topographically incorrect regrowth described above is likely to contribute to the incomplete functional recovery seen after nerve section and repair (Diamond and Foerster, 1992;Johnson et al, 2005). This impairment is in accordance with the reduced amplitude of the sensory potentials from the digits described after sciatic nerve injury and repair (Puigdellívol-Sánchez et al, 2002;Negredo et al, 2004).…”

Section: Regenerative Sproutingsupporting

confidence: 65%

Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair

Puigdellı́vol-Sánchez

Prats-Galino

Molander

2006

Brain Research

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Peripheral nerve injury is typically associated with long-term disturbances in sensory localization, despite nerve repair and regeneration. Here we investigate the extent of correct reinnervation by back-labeling neuronal soma with fluorescent tracers applied in the target area before and after sciatic nerve injury and repair in the rat. The subpopulations of sensory or motor neurons that had regenerated their axons to either the tibial branch or the skin of the third hindlimb digit were calculated from the number cell bodies labeled by the first and/or second tracer. Compared to the normal control side, 81% of the sensory and 66% of the motor tibial nerve cells regenerated their axons back to this nerve, while 22% of the afferent cells from the third digit reinnervated this digit. Corresponding percentages based on quantification of the surviving population on the experimental side showed 91%, 87%, and 56%, respectively. The results show that nerve injury followed by nerve repair by epineurial suture results in a high but variable amount of topographically correct regeneration, and that proportionally more neurons regenerate into the correct proximal nerve branch than into the correct innervation territory in the skin. SECTION: 4. Nervous System Development, Regeneration and Aging.

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Section: Regenerative Sproutingsupporting

confidence: 65%

Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair

Puigdellı́vol-Sánchez

Prats-Galino

Molander

2006

Brain Research

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“…We believe that this phenomenon is most likely based on increased axonal sprouting, rather than regeneration. It is well known that unmyelinated nociceptive fibers reinnervate the skin after denervation, which is similar to the reestablishment of neuromuscular junctions after degeneration in myelinated fibers (Diamond and Foerster, 1992; Nixon et al, 1984). Similar to our model of PDN, Griffin et al detected nerve regeneration or axonal sprouting after nerve injury (Griffin et al, 2010).…”

Section: Discussionmentioning

confidence: 81%

Nerve growth factor/p38 signaling increases intraepidermal nerve fiber densities in painful neuropathy of type 2 diabetes

Cheng

Dauch

Hayes

et al. 2012

Neurobiology of Disease

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Painful diabetic neuropathy (PDN) is a common, yet devastating complication of type 2 diabetes. At this time, there is no objective test for diagnosing PDN. In the current study, we measured the peptidergic intraepidermal nerve fiber densities (IENFD) from hind paws of the db/db mouse, an animal model for type 2 diabetes, during the period of mechanical allodynia from 6–12 wk of age. Intraepidermal nerve fibers (IENF) of the hind footpads were identified by protein gene product (PGP) 9.5 immunohistochemistry. The peptidergic IENF were determined by double immunofluorescence using anti-PGP9.5 and antibodies against tropomyosin-receptor-kinase (Trk) A. We observed a significant increase in PGP9.5-positive IENFD at 8 and 10 wk of age. Similarly, Trk A-positive peptidergic IENF, which also express substance P and calcitonin gene related peptide in db/db mice, were observed to be elevated from 1.5 to 2 fold over controls. This upregulation ended at 16 wk of age, in accordance with the reduction of mechanical allodynia. Anti-NGF treatment significantly inhibited the upregulation of peptidergic IENFD during the period of mechanical allodynia, suggesting increased neurotrophism may mediate this phenomenon. In addition, SB203580, an inhibitor of p38, blocked the increase in peptidergic IENFD in db/db mice. The current results suggest peptidergic IENFD could be a potential diagnostic indicator for PDN in type 2 diabetes. Furthermore, the inhibition of NGF-p38 signaling could be a potential therapeutic strategy for treating this painful condition.

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“…The peripheral nervous system has essential roles in cooperative functions of tissue and organ, such as voluntary and involuntary movement, regulatory external secretion of saliva, sebum and sweat, which are protection functions against the drying surface of mucosa and skin, and the perception of noxious stimulations, such as contact, warmth, pain and mechanical stresses. 7,16 Fully functional autologous or allogeneic skin grafting and artificial skin, which has no skin appendages, transplantation is clinically applicable for skin defects due to burn, injury and ulcer. 17,18 Reproducible sensory innervation of skin grafts and bioengineered skin equivalents could have been previously reported.…”

Section: Discussionmentioning

confidence: 99%

Single follicular unit transplantation reconstructs arrector pili muscle and nerve connections and restores functional hair follicle piloerection

Sato

Toyoshima

Toki

et al. 2012

The Journal of Dermatology

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The autologous transplantation of hair follicles that have been separated into single follicular units is an accepted treatment for androgenetic alopecia. Recent studies demonstrate that the multiple stem cell populations and surrounding cutaneous tissues coordinately regulate the hair follicle functions and skin homeostasis. Therefore, the critical issues for consideration regarding functional hair restoration therapy are reproduction the correct connectivity and cooperation with host cutaneous tissues, including the arrector pili muscle (APM) and nerve system. We report successful establishment of mouse single follicular transplantation model and autonomous restoration of transplanted hair follicle piloerection in mouse skin. Transplanted hair follicles were responsive to the neurotransmitter acetylcholine and formed proper connections with surrounding host tissues such as APM and nerve fibers, which in turn connect with not only the hair follicle bulge region but also the APM. These results demonstrate that the piloerection ability of transplanted hair follicles can be estimated quantitatively. This study makes a substantial contribution towards the development of transplantation therapy that will facilitate future functional regeneration therapy for skin and skin appendages.

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Recovery of sensory function in skin deprived of its innervation by lesion of the peripheral nerve

Cited by 22 publications

References 18 publications

Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair

Estimations of topographically correct regeneration to nerve branches and skin after peripheral nerve injury and repair

Nerve growth factor/p38 signaling increases intraepidermal nerve fiber densities in painful neuropathy of type 2 diabetes

Single follicular unit transplantation reconstructs arrector pili muscle and nerve connections and restores functional hair follicle piloerection

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