Recovery of Serum Testosterone, LH and FSH Levels Following Neoadjuvant Hormone Cytoreduction and Radical Radiotherapy in Localized Prostate Cancer

Recovery of serum testosterone after neoadjuvant androgen deprivation therapy and radical radiotherapy in localized prostate cancer

“…Previously we reported that a large majority (89%) of men who have a normal hormonal profile at baseline recover normal testosterone levels by 1 year after ADT and radiotherapy [8]. However, other studies indicated a prolonged and persistent reduction of testosterone levels after this treatment.…”

“…The sample size was based on our experience that the pre‐treatment mean ( sd ) baseline testosterone level was 16 (6) nmol/L [8]. As the sd for testosterone measurement was 1.7 nmol/L, a sample size of 50 would be enough to detect a difference of 3 nmol/L in levels before and after treatment with 93% power, and a difference of 2.5 nmol/L with 82% power with a two‐sided α of 0.05; P < 0.05 was considered to indicate statistical significance.…”

“…Castrate levels of testosterone are achieved in 2–4 weeks [4,5]. The time course of recovery of testosterone is poorly understood, with conflicting reports [6–8]. We previously reported the hormone recovery profile retrospectively in men with localized prostate cancer who had ADT and radiotherapy [8].…”

“…The time course of recovery of testosterone is poorly understood, with conflicting reports [6–8]. We previously reported the hormone recovery profile retrospectively in men with localized prostate cancer who had ADT and radiotherapy [8]. The serum testosterone levels recovered in most men (89%) by 1 year after treatment, but other groups have reported prolonged reduction of testosterone levels after ADT and radiotherapy.…”

Time course of serum testosterone and luteinizing hormone levels after cessation of long‐term luteinizing hormone‐releasing hormone agonist treatment in patients with prostate cancer

“…The authors of these studies have therefore insisted that the administration period needs to be strictly complied with to keep the T levels within the castrated level. By contrast, some reports have stated that patients showed continuous suppressed T levels for more than 6 months after cessation of LH-RH agonist treatment [7,8]. The time course of serum testosterone levels after LH-RH agonist therapy cessation seems to provide important information for determining the schedule of both intermittent endocrine therapy and LH-RH agonist therapy as adjuvant therapies for radical prostatectomy or radical radiotherapy.…”