Recovery of skeletal muscle mass after extensive injury: positive effects of increased contractile activity

Richard-Bulteau, Hélène; Serrurier, B.; Crassous, Brigitte; Banzet, Sébastien; Peinnequin, André; Bigard, Xavier; Koulmann, Nathalie

doi:10.1152/ajpcell.00355.2007

Cited by 44 publications

(25 citation statements)

References 48 publications

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“…The choice of BaCl 2 among myotoxins was based on its low cost and easy accessibility. BaCl 2 induces muscle fiber necrosis while completely preserving the basement membrane (4), and the subsequent muscle regeneration follows a process and timeline comparable to those induced by snake venoms or freezing (10,14,20,21,25,33). Ten-week-old male mice were used in all the regeneration experiments.…”

Section: Methodsmentioning

confidence: 99%

mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms

Ge¹,

Wu²,

Warnes³

et al. 2009

American Journal of Physiology-Cell Physiology

117

137

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Section: Methodsmentioning

confidence: 99%

mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms

Ge¹,

Wu²,

Warnes³

et al. 2009

American Journal of Physiology-Cell Physiology

117

137

View full text Add to dashboard Cite

show abstract

“…Few studies have investigated the role of exercise/contractile activity after skeletal muscle injury. It appears that exercise (running) increases skeletal muscle mass and the cross-sectional area of regenerating muscle as well as the recovery of metabolic properties (171,279). These effects can be explained by a higher activation of the mTOR pathway, the master regulator of cell growth and protein synthesis previously described as a redox-regulated molecule (294) and of PGC-1a (171), the master regulator of oxidative metabolism (191,196).…”

Section: A Exercise As Therapymentioning

confidence: 99%

Redox Control of Skeletal Muscle Regeneration

Moal

Pialoux

Juban

et al. 2017

Antioxidants & Redox Signaling

152

120

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Skeletal muscle shows high plasticity in response to external demand. Moreover, adult skeletal muscle is capable of complete regeneration after injury, due to the properties of muscle stem cells (MuSCs), the satellite cells, which follow a tightly regulated myogenic program to generate both new myofibers and new MuSCs for further needs. Although reactive oxygen species (ROS) and reactive nitrogen species (RNS) have long been associated with skeletal muscle physiology, their implication in the cell and molecular processes at work during muscle regeneration is more recent. This review focuses on redox regulation during skeletal muscle regeneration. An overview of the basics of ROS/RNS and antioxidant chemistry and biology occurring in skeletal muscle is first provided. Then, the comprehensive knowledge on redox regulation of MuSCs and their surrounding cell partners (macrophages, endothelial cells) during skeletal muscle regeneration is presented in normal muscle and in specific physiological (exercise-induced muscle damage, aging) and pathological (muscular dystrophies) contexts. Recent advances in the comprehension of these processes has led to the development of therapeutic assays using antioxidant supplementation, which result in inconsistent efficiency, underlying the need for new tools that are aimed at precisely deciphering and targeting ROS networks. This review should provide an overall insight of the redox regulation of skeletal muscle regeneration while highlighting the limits of the use of nonspecific antioxidants to improve muscle function. Antioxid. Redox Signal. 27, 276-310.

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“…TUNEL-positive myofiber nuclei (arrow) were located in the subsarcolemma, but central nuclei were not detected. Bar 50 lm [40]. Interestingly, Asakura et al [8] have demonstrated that MyoD regulates not only differentiation and proliferation of satellite cells but also the apoptosis response during the regenerating phase.…”

Section: Myofiber Apoptosis During the Inflammation Phasementioning

confidence: 99%

Myofiber apoptosis occurs in the inflammation and regeneration phase following eccentric contractions in rats

Sudo

Kano

2009

J Physiol Sci

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Eccentric contractions (ECC) induce myofibrillar collapse, edema, and inflammation in muscle cells. Although apoptosis of myonuclei following ECC is activated during the inflammatory phase, the apoptosis response of the regenerative phase remains to be elucidated. The aim of the present study was to determine the inflammatory and regenerative phase of the apoptosis responses induced by ECC. In anesthetized rats, the tibialis anterior muscles were subjected to ECC repeated 40 times, evoked by surface electric stimulation (100 Hz, 10 V) with mechanical muscle stretch. Apoptosis was examined in the control group and in groups 1, 3, 7, and 14 days after ECC (each group, n = 4-6). Terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL)-positive myonuclei were assessed by further labeling with dystrophin staining and DAPI. The expression of proteins related to apoptosis (Bcl-2 and Bax) was examined by Western blot assay. At 1 and 3 days, focal edema and necrotic myofibers invaded by mononuclear phagocytes were present, whereas regenerated myofibers with central nuclei were detected at 7 and 14 days. The occurrence of TUNEL-positive myonuclei increased significantly at 7 (7.0 +/- 1.5%) and 14 days (5.6 +/- 0.6%) compared with control (0.9 +/- 0.5%). Further we found that myonuclear apoptosis was restricted to the subsarcolemmal space at 7 and 14 days and markedly absent from the central nucleus. The Bax/Bcl-2 ratio was significantly higher at 3 (4.5 +/- 0.9) and 7 days (3.4 +/- 0.5) after ECC. In conclusion, myofiber apoptotic responses following ECC are present not only in the inflammatory phase but also persist during the regenerative phase.

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Recovery of skeletal muscle mass after extensive injury: positive effects of increased contractile activity

Abstract: Richard-Bulteau H, Serrurier B, Crassous B, Banzet S, Peinnequin A, Bigard X, Koulmann N. Recovery of skeletal muscle mass after extensive injury: positive effects of increased contractile activity.

Cited by 44 publications

References 48 publications

mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms

mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms

Redox Control of Skeletal Muscle Regeneration

Myofiber apoptosis occurs in the inflammation and regeneration phase following eccentric contractions in rats

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