1973
DOI: 10.1530/jrf.0.0330155
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Recovery of Spermatogenesis in Patients With Lymphoma After Treatment With Chlorambucil

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Cited by 49 publications
(6 citation statements)
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“…Data in reasonable numbers have been published for cyclophosphamide and chlorambucil administered as single agents. Thus, 20 g/M2 of cyclophosphamide [11,25,31] or 1.4 g/M2 of chlorambucil [29,30] may produce permanent azoospermia. One report also documents 400 mg of chlorambucil in an adult as gonadotoxic at least in the short term [8].…”
Section: Resultsmentioning
confidence: 99%
“…Data in reasonable numbers have been published for cyclophosphamide and chlorambucil administered as single agents. Thus, 20 g/M2 of cyclophosphamide [11,25,31] or 1.4 g/M2 of chlorambucil [29,30] may produce permanent azoospermia. One report also documents 400 mg of chlorambucil in an adult as gonadotoxic at least in the short term [8].…”
Section: Resultsmentioning
confidence: 99%
“…After several months of treatment, all 31 patients examined by Fairley et al [119] became oligo-or azoospermic. Return of spermatogenesis was first reported in lymphoma patients [116]. [115] reported the return of spermatogenesis in 12 of 26 males 15-49 months following prolonged treatment with CYC.…”
Section: Gonadal Toxicitymentioning
confidence: 95%
“…Also there was no morphological evidence of injury to the interstitial cells. Cheviakoff et al (1973) reported in a group of patients after withdrawal chlorambucil treatment a remision of the germinal lesion in two out of three patients. Eliasson et al (1974) stated that a normal relative proportion of biochemical components of the seminal plasma is a basic condition for the sunrival and fertility capacity of the spermatozoa.…”
Section: Discussionmentioning
confidence: 96%