The osmotic microbial fuel cell (OsMFC) is formed by combining forward osmosis (FO) and microbial fuel cells (MFC). Its excellent performance undoubtedly provided a new research direction for the application of FO and MFCs. However, the reverse solute flux (RSF) in FO also follows. RSF will cause a series of negative effects such as loss of draw solutions, decrease of water flux, and electricity generation. Therefore, inhibition of RSF is very necessary for the practical application of OsMFCs. Currently, there are much research and related reviews on RSF inhibition in FO but few studies on OsMFCs. To provide some new ideas for the inhibition of RSF in OsMFCs, we focused on three aspects: operating conditions, draw solutions, and FO membranes. Existing studies have demonstrated that some strategies are effective in OsMFC, including inhibitory effect of current generation, conventional inorganic draw solutions, membrane materials and orientation, and modified membranes. But there are many more strategies available. Using FO as a reference, strategies such as pressure-assisted osmosis and temperature control may be feasible and need to be investigated further. In the future, the inhibition or utilization of RSF can further improve the reactor performance and promote the early practical application of OsMFCs.