2019
DOI: 10.1002/cam4.2349
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RECQL5 plays an essential role in maintaining genome stability and viability of triple‐negative breast cancer cells

Abstract: Triple‐negative breast cancer (TNBC) is a malignancy that currently lacks targeted therapies. The majority of TNBCs can be characterized as basal‐like and has an expression profile enriched with genes involved in DNA damage repair and checkpoint response. Here, we report that TNBC cells are under replication stress and are constantly generating DNA double‐strand breaks, which is not seen in non‐TNBC cells. Consequently, we found that RECQL5 , which encodes a RecQ family DNA helicase invo… Show more

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Cited by 14 publications
(23 citation statements)
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“…Next, RNA-seq data in cancer cells were compared with RNA-seq data in clinical samples and five DDR-associated genes with a consistent response were identified: MCM8, MEN1, MDC1, NEIL1 and SLX1. These five genes are generally linked to tumorigenesis and progression, including cell proliferation, apoptosis and genome stability (53)(54)(55)(56)(57)(58). Their downstream targets are regulated by SRSF6 and may influence cancer progression in cells or in clinical samples.…”
Section: Discussionmentioning
confidence: 99%
“…Next, RNA-seq data in cancer cells were compared with RNA-seq data in clinical samples and five DDR-associated genes with a consistent response were identified: MCM8, MEN1, MDC1, NEIL1 and SLX1. These five genes are generally linked to tumorigenesis and progression, including cell proliferation, apoptosis and genome stability (53)(54)(55)(56)(57)(58). Their downstream targets are regulated by SRSF6 and may influence cancer progression in cells or in clinical samples.…”
Section: Discussionmentioning
confidence: 99%
“…RECQ5 is conserved from Drosophila to humans [9][10][11]. It has not been linked to any cancer-prone syndrome, but several lines of evidence suggest that its deficiency can cause genomic instability and cancer development [12][13][14][15]. RECQ5 has long been known to act as an anti-recombinase by disrupting RAD51 nucleoprotein filaments.…”
Section: Introductionmentioning
confidence: 99%
“…To help avoid these problems cells employ proteins known as antirecombinases to dismantle toxic Rad51 filaments ( 1–8 ). RECQ5 (also called RECQL5) is a tumor suppressor protein and antirecombinase that has been implicated as a possible breast cancer susceptibility gene ( 17 , 18 ), but its precise functions have been difficult to ascertain, in part because there is no known RECQ5 -associated syndrome ( 1 , 7 ). However, a population-based study of all five human RECQ helicase genes failed to identify any RECQ5 loss of function mutations, suggesting that the lack of a RECQ5 -associated syndrome may be due to embryonic lethality ( 19 ).…”
Section: Introductionmentioning
confidence: 99%