“…As noted above, research indicates that the combined use of alcohol and ATS may result in greater harms than their separate use. These harms include increased neurotoxicity (Cassel et al, 2005;Izco, Orio, O'Shea, & Colado, 2007), increased heart rate and blood pressure (Darke, Kaye, McKetin, & Duflou, 2008;Mendelson, Jones, Upton, & Jacob, 1995), extreme levels of heavy episodic drinking (McKetin, Chalmers, et al, 2014), engagement in risky behaviours (e.g., unsafe sex; Breen et al, 2006), and aggression (McKetin, Lubman, et al, 2014). However, despite the prevalence of ATS use and its common use with alcohol, knowledge of community patterns of concurrent and simultaneous ATS and alcohol use is limited, particularly with regard to ecstasy use (Breen et al, 2006;Kinner, George, Johnston, Dunn, & Degenhardt, 2012), and research examining the potential consequences of combined use is scarce (Kirkpatrick, Gunderson, Levin, Foltin, & Hart, 2012).…”