Recreational Use of Ketamine and Its Interaction with NMDA Receptors

Félix, Luís; Antunes, Luís; Campos, Sónia; Venâncio, Carlos; Coimbra, Ana M.

doi:10.1016/b978-0-12-800212-4.00062-5

Cited by 1 publication

(1 citation statement)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, hallucinations, emotional withdrawal, and "melting into the surrounding" may occur. It is also very likely for users (at very high doses of ketamine or those combining ketamine with alcohol or other drugs) to experience numbness, amnesia, more intense dissociations, and delirium [14].…”

Section: Introductionmentioning

confidence: 99%

An Update of Ketamine Illicit Use

Kleczkowska¹,

Zaremba²

2022

Ketamine Revisited - New Insights Into NMDA Inhibitors

View full text Add to dashboard Cite

Ketamine is a derivative of phencyclidine with unique anesthetic, analgesic, as well as antidepressant pharmacological properties. Despite its clinical use, ketamine is classified on the list with new psychoactive substances having psychedelic properties. The abuse trend of ketamine increasing globally, and it became a common club drug over the past few decades. Of note, recreational use of ketamine may pose a threat to public health, leading to numerous physical, as well as psychiatric negative effects. In addition, simultaneously or sequentially ketamine use with other drugs, resulting in serious health consequences. Currently, there are no specific treatment options for managing compulsive drug-seeking behavior in patients with ketamine use disorder, while the pharmacotherapy of side effects is limited and mostly symptomatic. In this chapter, we discuss ketamine abuse history. Further, we proposed the mechanisms of neural disinhibition underlying addiction development in ketamine-dependent patients. We have also included details of possible negative consequences focusing on long-term and recreational ketamine use for both, central and peripheral systems. Finally, we provide an overview of ketamine concomitant use and corresponding adverse interactions.

show abstract

Section: Introductionmentioning

confidence: 99%