Recrudescence of livedoid vasculopathy induced by COVID‐19

Tsutsui, Giuliane Minami; Miot, Hélio Amante

doi:10.1111/ijd.15423

Cited by 6 publications

(6 citation statements)

References 12 publications

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“…62,63 Recurrence of LV lesions has been seen in association with COVID-19 infection, which may be due to a combination of pro-inflammatory changes and hypercoagulability. 64 To our knowledge, de novo livedoid vasculopathy in association with COVID-19 has not been reported. Associations have been reported with pregnancy, hematologic malignancies, and solid organ carcinomas as well.…”

Section: Pathophysiologymentioning

confidence: 80%

Livedoid vasculopathy: A review with focus on terminology and pathogenesis

et al. 2022

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Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.

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Section: Pathophysiologymentioning

confidence: 80%

Livedoid vasculopathy: A review with focus on terminology and pathogenesis

et al. 2022

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“…Perry et al reported about a patient with secondary cryofibrinogenemia-induced LV associated with COVID-19 ( 35 ). Moreover, an exacerbation and a relapse of LV were reported after an infection with COVID-19 ( 36 , 37 ).…”

Section: Resultsmentioning

confidence: 99%

Livedoid vasculopathy – A diagnostic and therapeutic challenge

et al. 2022

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Livedoid vasculopathy is a rare, chronic-recurrent occlusive disorder in the microcirculation of dermal vessels. The clinical appearance is characterized by Livedo racemosa, painful ulceration, located in the distal parts of the lower extremities, followed by healing as porcelain-white, atrophic scars, the so-called Atrophie blanche. Different conditions that can promote a hypercoagulable state, such as inherited and acquired thrombophilias, autoimmune connective-tissue diseases and neoplasms, can be associated with livedoid vasculopathy. Therefore, livedoid vasculopathy is currently considered to be a coagulation disorder, clearly distinguished from inflammatory vasculitis. Although there are hints to hypercoaguability and secondary inflammation, pathophysiology is not completely understood. Diagnosis is made by synopsis of history, clinical and histopathological findings. Early and adequate therapy is essential to maintain life quality and avoid irreversible complications. Better understanding of molecular mechanisms is required to establish appropriate therapy regimens. This article presents the current state of knowledge about livedoid vasculopathy and proposes an algorithmic approach for diagnosis and therapy.

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“…Although not located in the lower legs, SARS-CoV2 infection is related to the presence of a thrombotic occlusive vasculopathy in the skin ( 29 ). With the previous knowledge, as SARS-CoV2 presents endothelial tropism and has the ability to favor microthrombosis in different tissues, it is not unexpected that the viral infection can worsen LV in previously affected patients, even in non-severe cases ( 30 ).…”

Section: Diagnosismentioning

confidence: 99%

A comprehensive review on pathogenesis, associations, clinical findings, and treatment of livedoid vasculopathy

Seguí

Llamas‐Velasco

2022

Front. Med.

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Livedoid vasculopathy (LV) is a thrombo-occlusive vasculopathy that involves the dermal vessels. Clinically, it is characterized by the presence of painful purpuric ulcers on the lower extremities. Histopathologically, it shows intraluminal fibrin deposition and thrombosis, segmental hyalinization, and endothelial proliferation. It is important to notice that the term “atrophie blanche” is descriptive and it includes not only patients with LV but also patients with a combination of vasculitis and vasculopathy, that is, LV and medium-sized vasculitis such as cutaneous polyarteritis nodosa (PANc). Diagnosis is based on a proper clinicopathological correlation, excluding the main differential diagnosis and considering vasculitis as a mimicker or concomitant diagnosis. Coagulation disorders must also be studied although they are not found in all LV. Its frequency is reviewed as well. Treatment of LV is challenging, and different therapies have been attempted. Among them, pain management, wound care, control of cardiovascular risk factors, and both antiplatelets and anticoagulants, mostly rivaroxaban, are the main therapies used. These different therapies as well as their degree of evidence are reviewed.

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Recrudescence of livedoid vasculopathy induced by COVID‐19

Cited by 6 publications

References 12 publications

Livedoid vasculopathy: A review with focus on terminology and pathogenesis

Livedoid vasculopathy: A review with focus on terminology and pathogenesis

Livedoid vasculopathy – A diagnostic and therapeutic challenge

A comprehensive review on pathogenesis, associations, clinical findings, and treatment of livedoid vasculopathy

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