Recruiting and retaining breast cancer survivors into a randomized controlled exercise trial

Irwin, Melinda L.; Cadmus, Lisa; Alvarez-Reeves, Marty; O’Neil, Michael; Mierzejewski, Eileen; Latka, Rebecca; Yu, Herbert; DiPietro, Loretta; Jones, Beth A.; Knobf, M. Tish; Chung, Gina G.; Mayne, Susan T.

doi:10.1002/cncr.23446

Cited by 89 publications

(139 citation statements)

References 46 publications

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“…More effective strategies such as dedicating specific resource to recruiting in all clinics, or using a cancer registry to identify women on AIs may increase recruitment. 42,43 Women declining participation gave reasons similar to those reported in other studies. 40,42,44 Providing more clarity about the intervention might have increased uptake and could be given during a follow-up phone call to nonresponders one to two weeks after sending the study invitation.…”

Section: Discussionsupporting

confidence: 66%

“…However, the ceiling effect observed with the PSEQ suggests a measure with proven validity in breast cancer populations may be more appropriate. Although the exercise diary return rate was similar to that reported in other studies, 42 options for improving the accuracy of recording activity should be explored; to include pedometers/activity trackers. These may have the added benefit of improving exercise adherence 54 and help to clarify between-group differences in exercise intensity.…”

Section: Discussionsupporting

confidence: 55%

“…This method has been found effective in previous exercise studies. 42,43 To reduce dropouts due to AI discontinuation, it would be recommended that randomization occur as soon as enough participants were recruited for two smaller groups.…”

Section: Discussionmentioning

confidence: 99%

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Nordic Walking as an Exercise Intervention to Reduce Pain in Women With Aromatase Inhibitor–Associated Arthralgia: A Feasibility Study

Fields

Richardson

Hopkinson

et al. 2016

Journal of Pain and Symptom Management

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Context. Women taking aromatase inhibitors as treatment for breast cancer commonly experience joint pain and stiffness (aromatase inhibitoreassociated arthralgia [AIAA]), which can cause problems with adherence. There is evidence that exercise might be helpful, and Nordic walking could reduce joint pain compared to normal walking.Objectives. To determine the feasibility of a trial of Nordic walking as an exercise intervention for women with AIAA. Methods. A feasibility study was carried out in a sample of women with AIAA using a randomized control design. Women were randomized to exercise (six-week supervised group Nordic walking training once per week with an increasing independent element, followed by six weeks 4 Â 30 minutes/week independent Nordic walking); or enhanced usual care. Data were collected on recruitment, retention, exercise adherence, safety, and acceptability. The Brief Pain Inventory, GP Physical Activity Questionnaire, and biopsychosocial measures were completed at baseline, six and 12 weeks.Results. Forty of 159 eligible women were recruited and attrition was 10%. There was no increased lymphedema and no long-term or serious injury. Adherence was >90% for weekly supervised group Nordic walking, and during independent Nordic walking, >80% women managed one to two Nordic walking sessions per week. From baseline to study end point, overall activity levels increased and pain reduced in both the intervention and control groups.Conclusion. Our findings indicate that women with AIAA are prepared to take up Nordic walking, complete a six-week supervised course and maintain increased activity levels over a 12-week period with no adverse effects. J Pain Symptom Manage 2016;-:-e-. Ó

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Section: Discussionsupporting

confidence: 66%

Section: Discussionsupporting

confidence: 55%

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Nordic Walking as an Exercise Intervention to Reduce Pain in Women With Aromatase Inhibitor–Associated Arthralgia: A Feasibility Study

Fields

Richardson

Hopkinson

et al. 2016

Journal of Pain and Symptom Management

View full text Add to dashboard Cite

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“…However, it has been suggested that these adherence rates may even be over-estimated as they tend to provide a "snapshot" rather than detailed information about the duration, intensity and frequency of exercise achieved [18]. For example, a study by Irwin et al found only 33% of post-treatment women within their program exercised for at least 150 minutes a week, while up to 94% exercise for at least 30 minutes a week [19]. No study was located which indicated the adherence rates of exercise among breast cancer patients outside of a research-generated exercise program.…”

Section: Introductionmentioning

confidence: 99%

Is bra discomfort a barrier to exercise for breast cancer patients?

Gho

Steele

Munro

2009

Support Care Cancer

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Goals of work Although exercise can provide a range of benefits for women living with a breast cancer diagnosis, many impediments to exercise exist. Several psychosocial and physical capacity impediments to exercise have been investigated, but no study has systematically investigated whether bras impede breast cancer patients from exercising. This study aimed to assess the extent to which exerciseinduced breast pain and bra discomfort were reported by women living with breast cancer and whether this breast pain and bra discomfort impeded these women from participating in physical activity. Patients and methods Seventy-four women living with a breast cancer diagnosis completed a custom-designed questionnaire. Frequency data were analyzed to identify the most common barriers to exercise, and features in current bra designs causing discomfort during exercise were established. Main results When analyzed according to mean score, "bra discomfort" ranked as the fourth highest barrier to exercise behind a lack of self-discipline, procrastination, and fatigued by exercise. A significant 70.3% of the sample (p<0.001) reported experiencing bra discomfort during exercise. Over half (57.7%) of these respondents reported the band as the most uncomfortable part of the bra. Conclusions This study has clearly established that bra discomfort, particularly bra band tightness, is a barrier to participating in physical activity for women living with a breast cancer diagnosis. To further encourage exercise in women living with a diagnosis of breast cancer, potential barriers to exercise, such as inadequate bra design, need to be modified to enable these women to enjoy the health benefits of exercising in comfort.

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“…Furthermore, research already suggests that exercise can benefit quality of life and functioning, [38][39][40][41][42] and at least 3 observational reports suggest it is associated with survival. [43][44][45] However, as Irwin et al describe, 46 there are significant challenges to the conduct of clinical trials that might provide us with guidelines for the delivery, and with the rigorous evidence base needed to evaluate the long-term benefits, of physical activity interventions. Monti et al 47 remind us that complementary (CAM) therapies also have appeal to survivors looking to enhance their recovery.…”

mentioning

confidence: 99%

Introduction: Partnering to embrace the future of cancer survivorship research and care

Rowland

Stefanek

2008

Cancer

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Objective: To describe the clinical and procedural outcomes of patients treated with the valve‐in‐valve technique for severe aortic insufficiency (AI) after balloon‐expandable transcatheter aortic valve replacement (TAVR). Background: Severe AI immediately after valve implantation is a notable complication of TAVR. It can be treated with a valve‐in‐valve technique which involves deploying a second valve within the first one to crush the leaflets of the first implant leaving a new functional valve. Methods: We analyzed data on 142 consecutive patients at our institution undergoing TAVR with the Sapien valve between November of 2007 and April of 2011. Etiologies of acute AI, procedural and intermediate term clinical outcomes were reported for those in whom a valve‐in‐valve procedure was necessary. Post‐hoc analysis of these cases with C‐THV imaging (Paieon Medical Ltd.) was performed to elucidate the mechanism for successful AI treatment. Results: A total of 5 of 142 (3.5%) patients were treated with the valve‐in‐valve technique. Etiologies of the aortic valve insufficiency included bioprosthesis malposition (n = 3), valve dysfunction (n = 1), and valve undersizing (n = 1). With placement of the second valve, the first valve dimensions increased to approach the nominal valve size while the second valve size remained less than nominal. Conclusions: The valve‐in‐valve technique is an appropriate bailout measure for patients with acute valvular AI after balloon‐expandable TAVR. © 2012 Wiley Periodicals Inc.

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Recruiting and retaining breast cancer survivors into a randomized controlled exercise trial

Cited by 89 publications

References 46 publications

Nordic Walking as an Exercise Intervention to Reduce Pain in Women With Aromatase Inhibitor–Associated Arthralgia: A Feasibility Study

Nordic Walking as an Exercise Intervention to Reduce Pain in Women With Aromatase Inhibitor–Associated Arthralgia: A Feasibility Study

Is bra discomfort a barrier to exercise for breast cancer patients?

Introduction: Partnering to embrace the future of cancer survivorship research and care

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