Recruitment and Retention in a Clinical Trial for Low Birth Weight, Premature Infants

Constantine, Wendy L.; Haynes, Christine W.; Spiker, Donna; Kendall–Tackett, Kathleen; Constantine, Norman A.

doi:10.1097/00004703-199302000-00001

Cited by 40 publications

(27 citation statements)

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“…The primary analysis group consisted of 985 families who consented to participate and joined the study (21% of the families who met the enrollment criteria refused consent; see Constantine, Haynes, Spiker, KendallTackett, & Constantine, 1993). Infants were randomized into two groups-only children who were not in the intervention group were included in these analyses (the intervention group had sigruficantly higher cognitive test scores at 2 and 3 years of age than did the group not receiving the early childhood educational program; Brooks-Gunn, Klebanov, Liaw, & Spiker, 1993).…”

Section: Designmentioning

confidence: 99%

The Contribution of Neighborhood and Family Income to Developmental Test Scores over the First Three Years of Life

Klebanov¹,

et al. 1998

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The effects of neighborhood and family income and family risk factors on developmental test scores at ages 1 through 3 are examined using a subsample ( N = 347) from the Infant Health and Development Program. Beneficial effects of low numbers of risks were found for scores at ages 1 through 3. Family poverty was associated with lower scores at ages 2 and 3. Neighborhood affluence was associated with higher scores at age 3. The family risks-test score association at ages 1 through 3 and family income-test score association at ages 2 and 3 were mediated by home environment. Mediated effects were stronger for family income-test score associations at age 3 than for neighborhood income. Moderating effects of family risk on family and neighborhood income effects revealed an interaction between family poverty and risks for scores at age 3. Explanations for the early links between family risks and test scores and the later links between income and test scores are discussed.

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Section: Designmentioning

confidence: 99%

The Contribution of Neighborhood and Family Income to Developmental Test Scores over the First Three Years of Life

Klebanov¹,

et al. 1998

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“…For example, some have suggested that parents who are unprepared to cope with a child’s illness are less likely to comply with follow-up [18]. A few studies have suggested that lower gestational age, center, female gender, lower maternal educational attainment, maternal race, and lack of an intact family are associated with attrition in pediatric and neonatal care [4-7, 19]. In a 5-center North American trial, withdrawal or loss to follow-up at 36 months was associated with gestational age, center, and socioeconomic/social support [4].…”

Section: Discussionmentioning

confidence: 99%

“…A 1995 German study reported that children who were multiples were more likely to follow up, while girls and children of mothers with lower educational attainment were more likely to drop out [5]. Similarly, regional Australian studies have reported that children who were difficult to follow up at 5 and 8 years were more likely to come from disrupted families and had mothers with less education [7, 9]. In the current study, neither in-hospital nor post-discharge medical characteristics of the children were related to attrition, but sociodemographic factors were strongly related to study completion.…”

Section: Discussionmentioning

confidence: 99%

“…Prior studies have not consistently identified the same demographic or socioeconomic predictors of attrition in neonatal clinical research, and no prior studies have examined the associations between families’ research participation experiences and study compliance [4-7]. To better understand factors associated with attrition in neonatal clinical research, we performed an ancillary study to the multicenter Prematurity and Respiratory Outcomes Program (PROP) [8].…”

Section: Introductionmentioning

confidence: 99%

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Patient, Family, and Center-Based Factors Associated with Attrition in Neonatal Clinical Research: A Prospective Study

et al. 2019

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Background: Attrition, or loss to follow-up, presents a significant threat to the integrity and validity of longitudinal clinical research. Little is known about predictors of attrition in neonatal clinical research, and no prior studies have examined how families’ experiences participating in research with their infants influences study compliance. Objective: To identify novel factors that were associated with attrition over 1 year of study follow-up among preterm infants enrolled in the multicenter Prematurity and Respiratory Outcomes Program (PROP) observational study. Methods: At discharge, research coordinators estimated the likelihood of attrition. The parents completed questionnaires about their experience with the study at discharge and at 1 year corrected age. The primary endpoint was completion of 4 PROP interviews during the first year. Logistic models were used to evaluate the associations between infant, family, and center-based characteristics and attrition. Results: Among 318 children, 283 (89%) met the primary endpoint. In bivariate analyses, lower maternal education, more people in the household, public insurance, and site were associated with attrition (p < 0.05). Parent survey responses, infant characteristics, and site characteristics were unrelated to attrition. Coordinators’ prediction of attrition was associated with completion of early study interviews; this effect waned over time. In multivariable analyses, lower maternal education and more people in the household were the factors most strongly associated with attrition. Conclusion: Future neonatal research should evaluate novel strategies to decrease the burden associated with study participation and reinforcement of study goals with families who have lower educational levels to facilitate participation and decrease attrition bias.

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“…8,9 Boyd et al 8 found that intervention group participants were more likely to drop out than participants in the control group. Neumark et al 11 explored the effects of subject and research design characteristics on nonparticipation and found that age and cancer diagnosis played roles in recruitment whereas ethnicity was associated with drop out.…”

Section: Review Of Literaturementioning

confidence: 99%

Recruitment and retention of women in two longitudinal studies of recovery from coronary events: a secondary analysis

Ashton

DiMattio

2004

Heart & Lung

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Recruitment and Retention in a Clinical Trial for Low Birth Weight, Premature Infants

Cited by 40 publications

References 0 publications

The Contribution of Neighborhood and Family Income to Developmental Test Scores over the First Three Years of Life

The Contribution of Neighborhood and Family Income to Developmental Test Scores over the First Three Years of Life

Patient, Family, and Center-Based Factors Associated with Attrition in Neonatal Clinical Research: A Prospective Study

Recruitment and retention of women in two longitudinal studies of recovery from coronary events: a secondary analysis

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