2003
DOI: 10.1128/mcb.23.3.815-825.2003
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Recruitment of a Repressosome Complex at the Growth Hormone Receptor Promoter and Its Potential Role in Diabetic Nephropathy

Abstract: The growth hormone (GH)-GH receptor (GHR) axis modulates growth and metabolism and contributes to complications of diabetes mellitus. We analyzed the promoter region of the dominant transcript (L2) of the murine GHR to determine that a cis element, L2C1, interacts with transcription factors NF-Y, BTEB1, and HMG-Y/I. These proteins individually repress GHR expression and together form a repressosome complex in conjunction with mSin3b. The histone deacetylase inhibitor trichostatin A increases expression of the … Show more

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Cited by 30 publications
(27 citation statements)
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“…In this latter study, p300 was able to acetylate NF-YB in vitro, but the function of this modification is currently unknown. Negative regulation through NF-Y, HDAC activity, and histone deacetylation also surfaced (28,30,31). These latter results suggest that NF-Y might be instrumental in the establishment of repressive as well as activating complexes on the regulated promoters.…”
mentioning
confidence: 62%
“…In this latter study, p300 was able to acetylate NF-YB in vitro, but the function of this modification is currently unknown. Negative regulation through NF-Y, HDAC activity, and histone deacetylation also surfaced (28,30,31). These latter results suggest that NF-Y might be instrumental in the establishment of repressive as well as activating complexes on the regulated promoters.…”
mentioning
confidence: 62%
“…Cooperative binding of multiple independent activators or repressors to each other and to DNA leads to synergistic changes in transcription by, for example, altering the recruitment of the basal RNA polymerase II transcriptional machinery to a promoter (Carey 1998;Ptashne and Gann 2002;Gowri et al 2003;Ptashne 2004). The result of this synergy is that small changes in the concentration of multiple regulators causes a greater-than-additive transcriptional response of their target gene.…”
Section: Resultsmentioning
confidence: 99%
“…However, recent evidence has demanded a broader definition in that growth hormone receptor (45), MHCII (46), and Hoxb4 (47) have all have been shown to be regulated through more distal NF-Y sites. In addition, a thorough chromatin immunoprecipitation on on-chip (microarray) analysis confirmed the exception to the position rule by demonstrating that NF-Y is not necessarily a promoter-specific factor.…”
Section: Discussionmentioning
confidence: 99%