Recruitment of GABAergic Interneurons in the Barrel Cortex during Active Tactile Behavior

Yu, Jianing; Hu, Hang; Agmon, Ariel; Svoboda, Karel

doi:10.1016/j.neuron.2019.07.027

Cited by 170 publications

(259 citation statements)

References 120 publications

(197 reference statements)

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“…Additionally, in L4, only 34% of the VIP-IN axonal boutons are located on GABA+ dendrites, suggesting weak inhibitory-inhibitory interactions in this layer (Zhou et al, 2017). Muñoz et al (2017) (Fu et al, 2015), and whisker-based object localization in the go/no-go task increases the spike rates of VIP-INs in the barrel cortex (Yu et al, 2019). On the other hand, the selectivity of VIP-INs in the visual go/no-go discrimination task did not change in the course of associative learning (Khan et al, 2018).…”

Section: Discussionmentioning

confidence: 98%

“…Activation of SOM-INs by acetylcholine may contribute to inhibition of PV interneurons and consequently to stronger disinhibition of principal cells. Moreover, touch-induced activation of SOM-INs, including L4, is time delayed, probably reflecting intracortical excitatory input rather than thalamic input (Yu et al, 2019); thus, L4 SOM-INs may increase their spike rates as a result of increased activity of excitatory cells during conditioning, further potentiating L4 disinhibition. SOM-PV disinhibition in the thalamocortical input layer during CS+UCS pairing may allow for wider spreading of the signal from the active vibrissae in the barrel cortex.…”

Section: Discussionmentioning

confidence: 99%

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Learning-induced plasticity in the barrel cortex is disrupted by inhibition of layer 4 somatostatin-containing interneurons

Dobrzański

Łukomska

Zakrzewska

et al. 2020

Preprint

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Learning-related plasticity in the cerebral cortex is linked to the action of disinhibitory circuits of interneurons. Pavlovian conditioning, in which stimulation of the vibrissae is used as conditioned stimulus, induces plastic enlargement of the cortical functional representation of vibrissae activated during conditioning, visualized with [ 14 C]-2-deoxyglucose (2DG). Using layer-specific, cell-selective DREADD transductions, we examined the involvement of somatostatin-(SOM-INs) and vasoactive intestinal peptide (VIP-INs)-containing interneurons in the development of learning-related plastic changes. We injected DREADD-expressing vectors into layer IV (L4) barrels or layer II/III (L2/3) areas corresponding to activated vibrissae. The activity of interneurons was modulated during training, and 2DG maps were obtained 24 h later. In mice with L4 but not L2/3 SOM-INs suppressed during conditioning, the plastic change of whisker representation and the conditioned reaction were absent. No effect of inhibiting VIP-INs was found. We report that the activity of L4 SOM-INs is indispensable for learning-induced plastic change.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Learning-induced plasticity in the barrel cortex is disrupted by inhibition of layer 4 somatostatin-containing interneurons

Dobrzański

Łukomska

Zakrzewska

et al. 2020

Preprint

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“…The increased amplitude of evoked inhibition in the high behavioral state was also an interesting finding. Fast spiking parvalbumin expressing interneurons receive strong direct sensory input from the thalamus and are responsible for feedforward inhibition (Sermet et al, 2019;Yu et al, 2019). The increased inhibition in high state could be attributed to enhanced activation of these fast spiking interneurons.…”

Section: Discussionmentioning

confidence: 99%

State-dependent changes in perception and coding in the mouse somatosensory cortex

Lee

Kheradpezhouh

Diamond

et al. 2020

Preprint

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An animal's behavioral state is reflected in the dynamics of cortical population activity and its capacity to process sensory information. To better understand the relationship between behavioral states and information processing, mice are trained to detect varying amplitudes of whisker-deflection under two-photon calcium imaging. Layer 2/3 neurons (n=1436) in the vibrissal primary somatosensory cortex are imaged across different behavioral states, defined based on detection performance (low to high-state) and pupil diameter. The neurometric curve in each behavioral state mirrors the corresponding psychometric performance, with calcium signals predictive of the animal's choice outcome. High behavioral states are associated with lower network synchrony, extending over shorter cortical distances. The decrease of correlations in variability across neurons in the high state results in enhanced information transmission capacity at the population level. The observed state-dependent changes suggest that the coding regime within the first stage of cortical processing may underlie adaptive routing of relevant information through the sensorimotor system.

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“…Despite these differences, both primary motor cortex-projecting and secondary somatosensory cortex-projecting S1 neurons could discriminate between Go and NoGo trials. Neural encoding of trial type during whisker-based object localization has also been shown to be both cell-type (Yu et al, 2019) and layer-specific, with a greater proportion of discriminating neurons located within layer 4 and 5 of the barrel cortex (O'Connor et al, 2010b). Taken Guo et al (2014b) and Chen et al (2017).…”

Section: Primary Sensory Corticesmentioning

confidence: 99%

Probing Cortical Activity During Head-Fixed Behavior

Bjerre

Palmer

2020

Front. Mol. Neurosci.

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The cortex is crucial for many behaviors, ranging from sensory-based behaviors to working memory and social behaviors. To gain an in-depth understanding of the contribution to these behaviors, cellular and sub-cellular recordings from both individual and populations of cortical neurons are vital. However, techniques allowing such recordings, such as two-photon imaging and whole-cell electrophysiology, require absolute stability of the head, a requirement not often fulfilled in freely moving animals. Here, we review and compare behavioral paradigms that have been developed and adapted for the head-fixed preparation, which together offer the needed stability for live recordings of neural activity in behaving animals. We also review how the head-fixed preparation has been used to explore the function of primary sensory cortices, posterior parietal cortex (PPC) and anterior lateral motor (ALM) cortex in sensory-based behavioral tasks, while also discussing the considerations of performing such recordings. Overall, this review highlights the head-fixed preparation as allowing in-depth investigation into the neural activity underlying behaviors by providing highly controllable settings for precise stimuli presentation which can be combined with behavioral paradigms ranging from simple sensory detection tasks to complex, cross-modal, memory-guided decisionmaking tasks.

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Recruitment of GABAergic Interneurons in the Barrel Cortex during Active Tactile Behavior

Abstract: Highlights d Spikes were recorded from cortical E, FS, SST, and VIP neurons during active touch d Whisking and touch activate FS neurons in the VPM thalamorecipient layers d Touch activates SST neurons with a delay d VIP neurons are excited during whisking

Cited by 170 publications

References 120 publications

Learning-induced plasticity in the barrel cortex is disrupted by inhibition of layer 4 somatostatin-containing interneurons

Learning-induced plasticity in the barrel cortex is disrupted by inhibition of layer 4 somatostatin-containing interneurons

State-dependent changes in perception and coding in the mouse somatosensory cortex

Probing Cortical Activity During Head-Fixed Behavior

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