Recruitment of Phagocytizing Cells into the Respiratory Tract as a Response to the Cytotoxic Action of Deposited Particles

Trends and Perspectives of the Biological Prophylaxis of Silicosis

“…Experimental data that demonstrate that this damage is partly compensated by enhanced contribution of neutrophil leukocytes to phagocytosis of cytotoxic particles and, thus, to their clearance from lungs, have been summarized previously (24). Later it was shown that the role of this compensatory mechanism became still more important under long-term quartz dust inhalation exposure (25).…”

“…The factor controlling this compensatory mechanism is the quantity of products of macrophage breakdown (PMB), which are produced by cytotoxic particles action and operate either directly (24), or through the activation of viable alveolar macrophage releasing a neutrophil attractant (25). It was shown, however, that in response to a fixed dose of the PMB the host might recruit into alveoli substantially different numbers of neutrophil leukocytes depending on its neurohormonal status (24,26,27).…”

“…It was shown, however, that in response to a fixed dose of the PMB the host might recruit into alveoli substantially different numbers of neutrophil leukocytes depending on its neurohormonal status (24,26,27). In particular, this recruitment is favored by previously injected M-cholinomimetic or a-adrenoblocking drugs and hindered by M-cholinolytic or sympathomimetic ones.…”

Some aspects of the problem of individual predisposition to silicosis.

“…The damage to the macrophage results in a greater tendency for cytotoxic quartz dust to be retained in lungs and triggers compensatory mechanisms leading to a better pulmonary clearance (9,10). On the other hand, it is the same damage to macrophages, due to properties of silica particles not yet fully understood, that serves as a trigger mechanism for enhanced fibrogenesis (11,12) and possibly the immunopathologic components of silicosis.…”

Lung Free Cells Following Short-term Inhalation of Coal Fly Ash Particles in Golden Hamsters

“…Generally, deposition of particles in alveoli causes the increase of lung free cells such as AMs or granulocytes. This change has been used as an indicator for assessing the inflammatory response or the stage of lung diseases [13,28]. Animals : Male golden hamsters obtained from the institute's breeding colony were used, since golden hamsters are relatively free of chronic lung diseases and the deposition pattern of aerosols in each lung lobe was studied in detail [20].…”