Recruitment of Specificity Protein 1 by CpG hypomethylation upregulates Na+-K+-2Cl− cotransporter 1 in hypertensive rats

Cho, Hyunmin; Lee, Hae-Ahm; Kim, Hye Young; Lee, Dong-Youb; Kim, In Kyeom

doi:10.1097/hjh.0b013e3283610fed

Cited by 13 publications

(7 citation statements)

References 32 publications

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“…There are numerous examples demonstrating an impairment of transcription factor binding by site-specific CpG methylation (Cho et al, 2013). In order to investigate whether similar mechanisms exist for some of the downstream targets of SOX6, we assessed the methylation status of CpG dinucleotides adjacent to putative SOX6 binding sites within the MEST upstream regulatory region.…”

Section: E)mentioning

confidence: 99%

The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis

et al. 2016

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An association between impaired fetal growth and the postnatal development of obesity has been established. Here, by comparing adipocytes differentiated from mesenchymal stem cells (MSCs) taken from the umbilical cord and derived from normal and growth-restricted neonates, we identified the transcription factor SOX6 as highly expressed only in growth-restricted individuals. We found that SOX6 regulates adipogenesis in vertebrate species by activating adipogenic regulators including PPARγ, C/EBPα and MEST. We further show that SOX6 interacts with β-catenin in adipocytes, suggesting an inhibition of WNT/β-catenin signaling, thereby promoting adipogenesis. The upstream regulatory region of the MEST gene in MSCs from growth-restricted subjects harbors hypomethylated CpGs next to SOX6 binding motifs, and we found that SOX6 binding is impaired by adjacent CpG methylation. In summary, we report that SOX6 is a novel regulator of adipogenesis synergizing with epigenetic mechanisms.

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Section: E)mentioning

confidence: 99%

The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis

et al. 2016

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“…As such, pharmacological studies have revealed key roles for the ubiquitous NKCC1 and renal specific NKCC2 in vascular and renal cells respectively. NKCC1 are involved in the suppression of myogenic response in microcirculatory beds [45,71] and NKCC2 are involved in blood pressure regulation through sodium reabsorption.…”

Section: Role Of Nkcc In Cardiovascular Diseasementioning

confidence: 99%

“…A histone activating code, acetylated histone H3, was increased and histone repressive code, trimethylated histone H3, was reduced in ang-II infused rats compared to the sham. Studies have shown that the recruitment of specificity protein 1 by CpG hypomethylation leads to the upregulation of NKCC1 in hypertensive rats [71]. This could mean that NKCC1 is epigenetically upregulated by histone modification (P<0.05) or DNA demethylation upon the development of hypertension (P<0.01) and that the methylation of CpG dinucleotides may play a role in the epigenetic maintenance of blood pressure through decreased expression of NKCC1.…”

Section: Nkcc In Vascular Cellsmentioning

confidence: 99%

Role of the Cation-chloride-cotransporters in Cardiovascular Disease

Azlan

Zhang

2020

Preprint

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The SLC12 family of cation-chloride-cotransporters (CCCs), comprising potassium chloride cotransporters (KCCs)-mediated Cl- extrusion relative to sodium chloride cotransporters (NKCCs)-mediated Cl- loading, play vital roles in cell volume regulation and ion homeostasis. These functions of the CCCs influence a variety of physiological processes, many of which overlap with the pathophysiology of cardiovascular disease. Although not all of the cotransporters have been linked to Mendelian genetic disorders, recent studies have provided new insights into their functional role in vascular and renal cells along with their contribution to cardiovascular diseases. Particularly, an imbalance in potassium levels promote the pathogenesis of atherosclerosis and disturbances in sodium homeostasis are one of the causes of hypertension. Recent findings even suggest hypothalamic signalling as a key signalling pathway in the pathophysiology of hypertension. In this review, we summarize and discuss the role of CCCs in cardiovascular disease with particular emphasis on knowledge gained in recent years on NKCCs and KCCs.

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“…As such, pharmacological studies have revealed key roles for the ubiquitous NKCC1 and renal specific NKCC2 in vascular and renal cells respectively. NKCC1 is involved in the suppression of myogenic response in microcirculatory beds [ 51 , 82 ] and NKCC2 is involved in blood pressure regulation through sodium reabsorption.…”

Section: Role Of Nkcc In Cardiovascular Diseasementioning

confidence: 99%

“…A histone activating code, acetylated histone H3, was increased and histone repressive code, trimethylated histone H3, was reduced in ang-II infused rats compared to the sham infused animals. Studies have shown that the recruitment of specificity protein 1 by CpG hypomethylation leads to the upregulation of NKCC1 in hypertensive rats [ 82 ]. This could mean that NKCC1 is epigenetically upregulated by histone modification or DNA demethylation upon the development of hypertension.…”

Section: Role Of Nkcc In Cardiovascular Diseasementioning

confidence: 99%

Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease

Azlan

Zhang

2020

Cells

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The SLC12 family of cation-chloride-cotransporters (CCCs) is comprised of potassium chloride cotransporters (KCCs), which mediate Cl− extrusion and sodium-potassium chloride cotransporters (N[K]CCs), which mediate Cl− loading. The CCCs play vital roles in cell volume regulation and ion homeostasis. The functions of CCCs influence a variety of physiological processes, many of which overlap with the pathophysiology of cardiovascular disease. Although not all of the cotransporters have been linked to Mendelian genetic disorders, recent studies have provided new insights into their functional role in vascular and renal cells in addition to their contribution to cardiovascular diseases. Particularly, an imbalance in potassium levels promotes the pathogenesis of atherosclerosis and disturbances in sodium homeostasis are one of the causes of hypertension. Recent findings suggest hypothalamic signaling as a key signaling pathway in the pathophysiology of hypertension. In this review, we summarize and discuss the role of CCCs in cardiovascular disease with particular emphasis on knowledge gained in recent years on NKCCs and KCCs.

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Recruitment of Specificity Protein 1 by CpG hypomethylation upregulates Na+-K+-2Cl− cotransporter 1 in hypertensive rats

Abstract: Our results indicate that recruitment of Sp1 by CpG hypomethylation leads to upregulation of Na⁺-K⁺-2Cl⁻ cotransporter 1 in hypertensive rats.

Cited by 13 publications

References 32 publications

The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis

The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis

Role of the Cation-chloride-cotransporters in Cardiovascular Disease

Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease

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