Recruitment rate, feasibility and safety of power training in individuals with Parkinson's disease: a proof-of-concept study

Abstract

| Background: It has been suggested that power training should be implemented in interventions in Parkinson's disease (PD). However, it is necessary to determine the feasibility and safety of training rapid movements in such individuals. Objectives: To determine the rate of recruitment of potential participants, the rate of attendance at training sessions, the levels of adherence to the intervention, and the rate of adverse events. Method: Patients with PD, users of the national public health system underwent power training of the lower limb muscles three times a week for 10 weeks. The number of people who were screened and recruited was recorded, as well as the rate of attendance at the training sessions and adherence to the intervention protocol. Safety was assessed by the presence of adverse events, pain, number of falls, and risk of injury associated with the intervention. Results: Over the course of eight months, 62 individuals were screened and only 13 completed the program. The rates of attendance and adherence were 88% and 97%, respectively. There were no adverse events during training. Two participants reported joint pain and one reported falls during the training period. Conclusions: The recruitment rate was low due to the subjects' difficulties with transportation and lack of interest. The high rates of adherence and attendance and the absence of adverse events suggest that power training is feasible and safe in PD.

Locomotor training using an overground robotic exoskeleton in long-term manual wheelchair users with a chronic spinal cord injury living in the community: Lessons learned from a feasibility study in terms of recruitment, attendance, learnability, performance and safety

“…Only one recent multi-center study investigating a single training session with a self-stabilizing robotic exoskeleton in individuals with SCI has reached a recruitment rate near 50% (i.e., 20 participants recruited among 46 screened for eligibility) [ 17 ]. Nonetheless, the recruitment rate of the present study compares relatively well to the rates reached in other feasibility studies investigating various task-specific gait-training programs offered to relatively homogeneous samples of individuals with neurological impairments (e.g., stroke = 6.7% [ 20 ], Parkinson disease = 11% [ 21 ]). In the present study, the most important reason (16 out of 35 potential participants = 46%) for not qualifying for the training program was due to musculoskeletal impairments with the leading cause being a reduced passive range of motion at the ankle, knee, or hip.…”

Recruitment rate and retention of stroke subjects in cross-sectional studies

“…This picture was also observed in other two Brazilian trials, which also investigated the recruitment rate and retention with individuals with neurological disorders, even though treatment was provided to the volunteers 7,12 . The first was a proof-of-concept design study with individuals with Parkinson Disease (PD), who were recruited in public health services 12 . The results showed that lack of interest was as one of the main obstacle while recruiting 12 .…”

“…The first was a proof-of-concept design study with individuals with Parkinson Disease (PD), who were recruited in public health services 12 . The results showed that lack of interest was as one of the main obstacle while recruiting 12 . Similarly, Scianni et al 7 conducted a clinical trial with acute stroke survivors (< 6 months), who were recruited from physical therapy out-patient clinics.…”

“…Lack of transportation was also an important obstacle to the recruitment rate and retention of the subjects 12 . Similarly, Scianni et al 7 found that 44% of the participants could not afford transportation to the training site.…”

Estudo Eletromiográfico Comparativo Entre Indivíduos Parkinsonianos E Saudáveis No Tempo De Resposta Muscular De Quadríceps E Eretores Do Tronco

“…Estima-se que aproximadamente 1% à 1,5% da população com mais de 65 anos apresenta DP, principalmente para o sexo masculino e com idade entre 50 e 60 anos [1]. Diante da perda de dopamina, em níveis baixos no cérebro, há uma redução de sinapses elétricas no tratocórtico espinhal, o qual é composto principalmente por axônios motores, associado à perda de fibras musculares do tipo II, responsáveis por contrações de movimentos rápidos, havendo, no entanto, o déficit de recrutamento de unidades motoras, gerando assim, significativa fraqueza muscular e bradicinesianos indivíduos parkinsonianos [2]. A eletromiografia é uma ferramenta de extrema importância na avaliação da condição muscular dos indivíduos portadores da DP, a qual nos permite verificar de uma forma mais precisa e quantitativa a condição neurofisiológica que causa os sintomas como tremor, movimentos incoordenados e desequilíbrio [3].…”