Rectal 5-aminosalicylic acid for induction of remission in ulcerative colitis

Marshall, John K.; Thabane, Marroon; Steinhart, A. Hillary; Newman, Jeffrey D.; Anand, Anju; Irvine, E. Jan

doi:10.1002/14651858.cd004115.pub2

Cited by 126 publications

(128 citation statements)

References 68 publications

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“…Rectal 5-ASA applications achieve remission rates in the literature around 67%. 15 In another study 78% of patients came into remission using a 5-ASA foam. 20 Topical steroids should be used in patients intolerant or refractory to 5-ASA products.…”

Section: Discussionmentioning

confidence: 98%

“…[15][16][17][18] 5-ASA foam preparations have a similar distribution pattern as compared to enemas. 19 5-ASA suppositories in a dosage of 1 g/day are the preferred therapy of mild to moderate proctitis.…”

Section: Introductionmentioning

confidence: 89%

“…33 Furthermore, a meta-analysis showed a higher efficiency of rectal 5-ASA treatments compared to topical steroids. 23,3,15 However, the combination of rectal steroids and 5-ASAs seems to be beneficial. 21 Unexpectedly, in our cohort only a minority of patients with pancolitis received rectal therapy.…”

Section: 32mentioning

confidence: 99%

“…22 A meta-analysis of 33 studies showed that topical 5-ASA is more effective as compared to topical conventional steroids or budesonide. 15,3,23 Remission also can be maintained by topical treatment of at least two years duration. [9][10][11]24,25 For maintenance 3 g of 5-ASA total per week is recommended.…”

Section: Introductionmentioning

confidence: 99%

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Topical therapy is underused in patients with ulcerative colitis

Seibold

Fournier

Beglinger

et al. 2014

Journal of Crohn's and Colitis

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The availability of new topical preparations for the treatment of left sided ulcerative colitis offers a therapy optimization for many patients. Rectal application of steroids and 5-aminosalicylic acid (5-ASA) is associated with fewer side effects and has a higher therapeutic efficacy in left-sided colitis as compared to a systemic therapy. Therefore, we were interested in the use of topical therapy in patients with ulcerative colitis. The key question was whether topical treatment is more frequently used than oral therapy in patients with proctitis and left sided colitis. Data of 800 patients of the Swiss IBD cohort study were analyzed. Sixteen percent of patients of the cohort had proctitis, 21% proctosigmoiditis and 41% pancolitis. Topical therapy with 5-ASA or corticosteroids was given in 26% of patients with proctitis, a combined systemic and topical treatment was given in 13%, whereas systemic treatment with 5-ASA without topical treatment was given in 29%. Proportion of topical drug use decreased with respect to disease extension from 39% for proctitis to 13.1% for pancolitis (P = 0.001). Patients with severe colitis received a significantly higher dose of topical 5-ASA than patients in remission.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 89%

Section: 32mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Topical therapy is underused in patients with ulcerative colitis

Seibold

Fournier

Beglinger

et al. 2014

Journal of Crohn's and Colitis

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“…W razie jej nieskuteczności lub w przypadku cięższego przebiegu choroby należy obok terapii miejscowej mesalazyną zastosować preparaty kwasu 5-aminosalicylowego (5-ASA) także w postaci doustnej. Jeśli taka terapia nie jest skuteczna, lekami alternatywnymi są steroidy stosowane doodbytniczo (czopki, pianki doodbytnicze) w połączeniu z doustnymi preparatami 5-ASA [7,38].…”

Section: A -100% B -0% C -0% D -0% E -0%unclassified

Guidelines for the management of ulcerative colitis. Recommendations of the Working Group of the Polish National Consultant in Gastroenterology and the Polish Society of Gastroenterology

Eder¹,

Łodyga²,

Łykowska‐Szuber³

et al. 2013

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Rectal 5-aminosalicylic acid for maintenance of remission in ulcerative colitis

Marshall

Thabane

Steinhart

et al. 2012

Cochrane Database of Systematic Reviews

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The limited data available suggest that rectal 5-ASA is effective and safe for maintenance of remission of mild to moderately active distal UC. Well designed randomized trials are needed to establish the optimal dosing regimen for rectal 5-ASA, to compare rectal 5-ASA with rectal corticosteroids and to identify subgroups of patients who are more or less responsive to specific rectal 5-ASA regimens. The combination of oral and rectal 5-ASA appears to be more effective than either oral or rectal monotherapy for induction of remission. The efficacy of combination therapy for maintenance of remission has not been assessed and could be evaluated in future trials.

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Rectal 5-aminosalicylic acid for induction of remission in ulcerative colitis

Cited by 126 publications

References 68 publications

Topical therapy is underused in patients with ulcerative colitis

Topical therapy is underused in patients with ulcerative colitis

Guidelines for the management of ulcerative colitis. Recommendations of the Working Group of the Polish National Consultant in Gastroenterology and the Polish Society of Gastroenterology

Rectal 5-aminosalicylic acid for maintenance of remission in ulcerative colitis

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