Rectal and Sigmoid Involvement Secondary to Carcinoma of the Prostate

Gengler, Leon; Baer, Jeanne W.; Finby, Nathaniel

doi:10.2214/ajr.125.4.910

Cited by 39 publications

(11 citation statements)

References 9 publications

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“…Of these, the rectum is the least commonly involved by prostate cancer. Rectal involvement, by direct invasion or metastasis, occurs in 1.5% to 11% of those with prostate cancer [11,12,31,32]. The possible reason for rectal involvement may be related to tumor’s biological behavior such as gene aberration or tumor dedifferentiation, positive surgical margin or collision tumour in the very rare situation [33-35].…”

Section: Discussionmentioning

confidence: 99%

Factors associated with the survival of prostate cancer patients with rectal involvement

Wang

Yao

2014

Diagn Pathol

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BackgroundProstate cancer patients with rectal involvement are rare, and the factors associated with the survival of these patients are yet to be elucidated.Patients and methodsWe collected data on patients who were admitted to our hospital for prostate cancer in the last thirteen years and of those in studies in the literature. The associations of clinical characteristics with survival were evaluated using Cox regression models.ResultsThis study included 94 patients (5 admitted to our hospital and 89 from studies in the literature) of prostate cancer with rectal involvement. 11 patients in the group of synchronous rectal involvement at first cancer diagnosis (n = 58) and 23 patients in the group of metachronous diagnosis of rectal involvement (n = 29) died at the latest follow up. The estimated overall survival rate (% ± SE) at 1, 3, and 5 years were 68.3 ± 5.3%, 54.4 ± 7.2%, and 38.1 ± 11.1%, respectively. In the Cox univariate analysis, Asian prostate cancer (p = 0.001) was associated with better survival, while rectal bleeding (p = 0.043), metachronous presentation of development of rectal involvement (p = 0.000), prior hormonal therapy (p = 0.000) and extrarectal metastases (p = 0.054) were associated with poor survival. In multivariate analysis, prior hormone therapy (HR = 14.540, p = 0.000) and rectal bleeding (HR = 2.195, p = 0.041) retained independent poor prognostic values. There were 13 patients survived for more than 3 years, the longest survival time was 96 months. Total pelvic extenteration (TPE) combined with hormonal therapy in 12 hormone-untreated prostate cancer give us six of thirteen long-term survivors for more than 3 years in this series.ConclusionsOur findings suggest that rectal involvement does not necessarily predict a worse outcome when presenting as a previously hormone-untreated disease and that the prognosis was worse when presenting as a hormone relapsed disease. Prior hormone therapy and rectal bleeding were associated independently with a significantly poor overall survival in prostate cancer patients with rectal involvement. TPE combined with hormonal therapy appears to confer better overall survival in hormonally untreated patients.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1604504118106105.

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Section: Discussionmentioning

confidence: 99%

Factors associated with the survival of prostate cancer patients with rectal involvement

Wang

Yao

2014

Diagn Pathol

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“…However, the occurrence of rectal annular constriction due to infiltration by bladder cancer is relatively rare. Previously, it was believed that the rectal mucosa could remain intact because it was thought that metastatic spread would not penetrate the muscular layers of the bowel [ 2 ]. However, Aneese et al [ 3 ] reported a case of bladder urothelial carcinoma extension, via the prostate, into the rectum that formed a multinodular, oval, ulcerated, friable mass.…”

Section: Discussionmentioning

confidence: 99%

Invasive urothelial carcinoma of urinary bladder presenting with annular constriction and mimicking proctitis observed by colonoscopy: A case report

Liu

et al. 2021

International Journal of Surgery Case Reports

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Highlights The occurrence of rectal annular constriction due to infiltration by bladder cancer is relatively rare, and difficult diagnosis by colonoscopy. The images including computed tomography, colonoscopy, and magnetic resonance imaging was fully recorded in our report. The poor prognosis was noted from literature review with no record for survival >2 years after diagnosis of a rectal lesion.

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“…Prostate cancer metastasis to the recto-sigmoid region can occur by subserosal metastatic implant of the malignant tissues [6]. The incidence of rectal infiltration by prostatic adenocarcinoma is extremely rare, being encountered on average once every two years by a busy colorectal practice [7].…”

Section: Discussionmentioning

confidence: 99%