Rectal and Vaginal Absorption of Peptides and Proteins

Muranishi, Shozo; Yamamoto, Akira; Okada, Hiroaki

doi:10.1007/978-1-4615-2898-2_9

Cited by 14 publications

(4 citation statements)

References 80 publications

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“…It dissociates and is absorbed into the capillaries in its dimeric or monomeric form. The absorption of the poorly solubilized insulin at rectal pH is achieved through the transcellular and paracellular routes (Muranishi et al 1993). In the transcellular route, the lipophilicity of the suppository formulation plays an essential role, whereas a simple drug diffusion process enables the drug to be absorbed through the paracellular route.…”

Section: Discussionmentioning

confidence: 99%

In vitro characteristics of an insulin suppository developed using palm oil base (HAMIN^®) and its hypoglycaemic effect on rabbits

Nair

Chik

Noordin

2015

Frontiers in Life Science

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The long-term administration of insulin requires the development of new delivery routes. Using a base developed in-house, called HAMIN ® , an insulin suppository containing 100 units (U) of insulin was formulated. The suppository was subjected to stability testing at various temperatures and the assay value was monitored. Other physical factors such as hardness, disintegration time, thermal analysis and dissolution were also tested. The suppository released more than 80% of its drug content in 30 min, and was stable for up to 11 months at − 20°C. The suppository effect was studied on 11 New Zealand white rabbits, with body weight ranging from 1.6 to 2.1 kg. The results show that there was a marked reduction in glucose content when the suppository was inserted. The average drop in glucose content was 2.7 mmol/L in 15 min from the time of insertion. The maximum drop in glucose content reached 3.9 mmol/L in 2 h. Plasma insulin level, quantified using an enzyme-linked immunosorbent assay, showed a value of more than 100 μIU insulin/ml blood after 30 min. Although the insulin bioavailability was expectedly low, the rate at which the hypoglycaemic effect took place and the percentage of glucose reduction were comparable to results after subcutaneous injection.

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Section: Discussionmentioning

confidence: 99%

In vitro characteristics of an insulin suppository developed using palm oil base (HAMIN^®) and its hypoglycaemic effect on rabbits

Nair

Chik

Noordin

2015

Frontiers in Life Science

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“…These multilayered epithelia normally afford a barrier to external signaling by presenting a wall of cornifi ed enucleated cells on the apical surface which lack most membrane receptors and signaling pathways (Anderson et al 2014 ). Lipophilic molecules from semen could be absorbed through the vaginal epithelium to achieve local or systemic effects (Muranishi et al 1993 ).…”

Section: Vagina and External Genitaliamentioning

confidence: 99%

The Male Role in Pregnancy Loss and Embryo Implantation Failure

Bronson¹

2015

Advances in Experimental Medicine and Biology

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“…Besides avoiding the hepatic first pass metabolism and reducing the GI and hepatic side effects, a high permeability to a wide range of drug molecules including peptides and proteins can be achieved by using the vaginal route 76 . Also, it has the possibility for uterine targeting of active agents such as progesterone which produces its effect on the uterus and is highly metabolized when administered orally 77 .…”

Section: Vaginal Mucosa As a Site For Drug Deliverymentioning

confidence: 99%

Mucoadhesive Polymers as Efficient Drug Delivery Systems

El-Gindy

El-Mahdy

Soliman

et al. 2015

Bulletin of Pharmaceutical Sciences. Assiut

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The drug action can be reinforced as a result of the development of new drug delivery systems. Over the past few decades, mucosal drug delivery has received a great deal of attention to improve both the local and systemic drug effects. Drug delivery across the mucosa bypasses the first-pass hepatic metabolism and avoids the degradation caused by the gastrointestinal enzymes. Mucoadhesive dosage forms are designed to enable prolonged retention at the desirable site of action, provide sustained release of drug and thus, lead to an improved bioavailability, as well as therapeutic outcomes. Compared with other mucosal tissues, vaginal mucosal cavity is more appropriate and attractive for drug delivery. In addition, a prolonged contact of mucoadhesive dosage forms with the vaginal mucosa may be achieved more easily than at other absorption sites like rectum or intestinal mucosa. This review aims to highlight the recent advances in the study of mucoadhesion and mucoadhesive polymers. It provides an overview of the structure of mucosal membranes, the mechanism and theories involved in mucoadhesion, and finally it describes briefly the main characteristics and the advantages of vaginal mucoadhesive drug delivery systems compared with other delivery systems.

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Rectal and Vaginal Absorption of Peptides and Proteins

Cited by 14 publications

References 80 publications

In vitro characteristics of an insulin suppository developed using palm oil base (HAMIN^®) and its hypoglycaemic effect on rabbits

In vitro characteristics of an insulin suppository developed using palm oil base (HAMIN^®) and its hypoglycaemic effect on rabbits

The Male Role in Pregnancy Loss and Embryo Implantation Failure

Mucoadhesive Polymers as Efficient Drug Delivery Systems

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Rectal and Vaginal Absorption of Peptides and Proteins

Cited by 14 publications

References 80 publications

In vitro characteristics of an insulin suppository developed using palm oil base (HAMIN®) and its hypoglycaemic effect on rabbits

In vitro characteristics of an insulin suppository developed using palm oil base (HAMIN®) and its hypoglycaemic effect on rabbits

The Male Role in Pregnancy Loss and Embryo Implantation Failure

Mucoadhesive Polymers as Efficient Drug Delivery Systems

Contact Info

Product

Resources

About

In vitro characteristics of an insulin suppository developed using palm oil base (HAMIN^®) and its hypoglycaemic effect on rabbits

In vitro characteristics of an insulin suppository developed using palm oil base (HAMIN^®) and its hypoglycaemic effect on rabbits