Rectal Cancer Associated with Schistosomiasis: Report of Two Cases and Review of the Literature

Al-Mashat, Faisal; Sibiany, Abdulrahman; Radwi, Amer; Bahadur, Yasir A.; Al-Radi, Asim; Meir, Hadir; Ahmed, Gamal E.

doi:10.5144/0256-4947.2001.65

Cited by 13 publications

(9 citation statements)

References 9 publications

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“…Since this time, there have been a large number of patients reported individually or in groups with both colorectal carcinoma and evidence of infection by S. japonicum (reviewed in [11]). Case reports and small case series continue to appear in the literature with some regularity, including the authors of this paper [12–15]. Many of these case reports and case series originated in areas of endemic S. japonicum , including Japan, China, and the Philippines, or from immigrants from these areas.…”

Section: Schistosoma Japonicummentioning

confidence: 87%

“…Patients, both individually and in small series, with evidence of both colorectal adenocarcinoma and S. mansoni infection have been reported for decades, primarily in the Middle East [12, 41–43]. However, unlike S. japonicum , there is a distinct lack of epidemiological evidence that links the geographical distribution of S. mansoni to cancers of any type, gastrointestinal or otherwise.…”

Section: Schistosoma Mansonimentioning

confidence: 99%

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Gastrointestinal Neoplasia Associated with Bowel Parasitosis: Real or Imaginary?

Peterson

Weidner

2011

Journal of Tropical Medicine

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Several parasitic species are well known to have carcinogenic properties, namely; Schistosoma hematobium (squamous cell carcinoma of the bladder) and the liver flukes Opisthorchis and Chlonorchis (cholangiocarcinoma). A large number of parasites are known to colonize the gastrointestinal tract. We sought to review the evidence that implicates these parasites in gastrointestinal neoplasia. Schistosoma japonicum, which is endemic primarily in east Asia, has been shown in multiple studies to convey a mildly increased risk of colorectal adenocarcinoma. The data supporting a causative role for Schistosoma mansoni in colorectal or other neoplastic processes are less convincing, limited primarily to small case-control studies and case series. Reports of possible associations between other gastrointestinal parasites (e.g., E. histolytica and A. lumbricoides) and neoplasia may be found in the literature but are limited to individual cases. We conclude that, other than S. japonicum and to a lesser extent S. mansoni, there is little evidence of an association between gastrointestinal parasites and neoplasia.

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Section: Schistosoma Japonicummentioning

confidence: 87%

Section: Schistosoma Mansonimentioning

confidence: 99%

Gastrointestinal Neoplasia Associated with Bowel Parasitosis: Real or Imaginary?

Peterson

Weidner

2011

Journal of Tropical Medicine

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“…Intestinal schistosomiasis has been linked to development of colorectal cancers with a number of documented cases reported in some parts of Africa and Asia [ 4 – 7 ]. Both S. mansoni and S. japonicum cause intestinal schistomiasis.…”

Section: Discussionmentioning

confidence: 99%

“…Colorectal cancer (CRC) is reported to have varying degrees of incidences worldwide, with its prevalence on the increase in the developing nations, mainly due to change of diet (a low fiber, high fat diet) and physical inactivity [ 1 ]. These factors are among the common universally known risk factors for colonic adenocarcinoma [ 2 , 3 ] with some rare risk factors like schistosomal colitis being observed in Africa, Middle East, and South-East Asia [ 4 ]. Studies have highlighted an association between Schistosoma japonicum infections with adenocarcinoma of the colon while the association of S. mansoni with colorectal cancer remains with few supporting evidence [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…These factors are among the common universally known risk factors for colonic adenocarcinoma [ 2 , 3 ] with some rare risk factors like schistosomal colitis being observed in Africa, Middle East, and South-East Asia [ 4 ]. Studies have highlighted an association between Schistosoma japonicum infections with adenocarcinoma of the colon while the association of S. mansoni with colorectal cancer remains with few supporting evidence [ 4 – 6 ]. We present the first documented case in Tanzania of a patient with intestinal schistosomiasis associated with colorectal cancer from Lower Moshi Tanzania (an area with irrigation scheme for rice fields and also with high prevalence of schistosomiasis) who presented to us as a case of intestinal obstruction and found to have adenocarcinoma of sigmoid colon and a deposited S. mansoni ova at histology after laparotomy.…”

Section: Introductionmentioning

confidence: 99%

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Colorectal cancer in a patient with intestinal schistosomiasis: a case report from Kilimanjaro Christian Medical Center Northern Zone Tanzania

et al. 2017

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BackgroundColorectal cancer associated with chronic intestinal schistosomiasis has been linked with the chronic inflammation as a result of schistosomal ova deposition in the submucosal layer of the intestine. Among all species Schistosoma japonicum has been more linked to development of colorectal cancer as compared to Schistosoma mansoni due to absence of population-based studies to support the association. Despite the weak evidence, some cases have been reported associating S. mansoni with development of colorectal cancer.Case PresentationWe report a patient who presented to us as a case of intestinal obstruction and found to have a constrictive lesion at the sigmoid colon at laparotomy, then later found to have colorectal cancer with deposited S. mansoni ova at histology.ConclusionGiven the known late complications of schistosomiasis, and as S. mansoni is endemic in some parts of Tanzania, epidemiological studies are recommended to shed more light on its association with colorectal cancer.

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From the discovery of helminths to the discovery of their carcinogenic potential

Jain,

Rana

2023

Parasitol Res

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Rectal Cancer Associated with Schistosomiasis: Report of Two Cases and Review of the Literature

Cited by 13 publications

References 9 publications

Gastrointestinal Neoplasia Associated with Bowel Parasitosis: Real or Imaginary?

Gastrointestinal Neoplasia Associated with Bowel Parasitosis: Real or Imaginary?

Colorectal cancer in a patient with intestinal schistosomiasis: a case report from Kilimanjaro Christian Medical Center Northern Zone Tanzania

From the discovery of helminths to the discovery of their carcinogenic potential

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