Rectal Cancer in the Young Patient

Endreseth, Birger Henning; Romundstad, P.; Myrvold, H. E.; Hestvik, Unn E.; Bjerkeset, T; Wibe, Arne

doi:10.1007/s10350-006-0558-6

Cited by 43 publications

(31 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the current study, younger patients were more likely to present in stage III. This is also consistent with previously conducted studies Endreseth et al, 2006). Variable outcomes have been reported for rectal cancers presenting at young age.…”

Section: Discussionsupporting

confidence: 93%

Outcome of Rectal Cancer in Patients Aged 30 Years or Less in the Pakistani Population

Ali

Bhatti²,

Khattak³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: The incidence of rectal cancer is increasing in younger age groups. Limited data is available regarding survival outcome in younger patients with conflicting results from western world. The goal of this study was to determine survival in patients with rectal cancer <30 years of age and compare it with their older counterparts in the Pakistani population. Materials and Methods: A retrospective chart review of patients operated for rectal adenocarcinoma between January 2005 and December 2010 was performed. Patients were divided into two groups, Group 1 aged ≤30years and Group 2 aged >30years. Patient characteristics, surgical procedure, histopathological details and number of loco-regional and distant failures were compared. Expected 5 year survival was calculated using Kaplan Meier curves and significance was determined using the Log rank test. Results: There were 38 patients in group 1 and 144 in group 2. A significantly high number of younger patients presented with poorly differentiated histology (44.7% vs 9.7%) (p=0.0001) and advanced pathological stage (63.1% vs 38.1%) (p=0.04). Predicted overall 5 year survival was 38% versus 57% in groups I and II, respectively (p=0.05). Disease free survival was 37% versus 52% and was significantly different (p=0.007). Conclusions: Early onset rectal cancer is associated with poor pathological features and a worse outcome in Pakistani population.

show abstract

Section: Discussionsupporting

confidence: 93%

Outcome of Rectal Cancer in Patients Aged 30 Years or Less in the Pakistani Population

Ali

Bhatti²,

Khattak³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Interestingly, we found a significant difference of VEGF-D expression between different age group ( ^ 68 and 1 68 years). This might partially explain why CRC in younger people is more invasive than in older people [27,28] . An increased MVD is a negative prognostic indicator in several types of cancer; however, this relationship is A high MVD has been reported to be associated with a poor prognosis [29] , to have little or no impact on survival [30] , or to predict longer survival [31] .…”

Section: Discussionmentioning

confidence: 99%

Vascular Endothelial Growth Factors C and D Represent Novel Prognostic Markers in Colorectal Carcinoma Using Quantitative Image Analysis

Feng³

et al. 2007

Eur Surg Res

View full text Add to dashboard Cite

Background/Aims: Vascular endothelial growth factor C (VEGF-C) and vascular endothelial growth factor D (VEGF-D) are potent lymphangiogenic and angiogenetic mediators in many kinds of tumors. However, the exact impacts of VEGF-C and VEGF-D on the prognosis of colorectal cancer (CRC) remain elusive. The aims of this study were to demonstrate the expression of VEGF-C and VEGF-D and to correlate their expression levels with clinicopathological factors and long-term survival in patients with CRC. Patients and Methods: Between January 1996 and January 1998, 69 patients with pathologically confirmed CRC who received routine follow-up at the Ruijin Hospital were included in this study. VEGF-C and VEGF-D protein expression and microvessel density of 69 surgical specimens were assessed by immunohistochemistry, with 20 samples of normal colorectal tissues as controls. All patients were followed up for 108 months or until death. The Immunohistochemical stains were quantified and analyzed by means of a Zeiss Axioplan 2 imaging analysis system. Results: The protein expression of VEGF-C and VEGF-D in tumor tissues was much higher than that in normal colorectal tissues (p < 0.01). The VEGF-C expression significantly correlated with lymph node metastasis (p = 0.011) and clinical stages of CRC (p < 0.01). The VEGF-D expression correlated with patient ages (p = 0.013), depth of tumor invasion (p = 0.013), and lymph node metastasis (p = 0.028). The expression of VEGF-C and VEGF-D was significantly correlated with the microvessel density. Both overall survival and disease-free survival at 108 months were significantly lower in the CRC patients with a high VEGF-C and/or a high VEGF-D expression, and the patients with a high expression of both VEGF-C and VEGF-D had the shortest overall survival and disease-free survival when compared with other patients. Conclusion: The VEGF-C or VEGF-D expression was significantly correlated with lymph node metastasis and long-term prognosis and could be applied as prognostic markers in CRC.

show abstract

“…Young patients with rectal cancer more often present with advanced-stage disease and unfavourable tumour morphology compared with middle-aged patients [6][7][8][9][10]. Studies focusing on survival in young rectal cancer patients have shown at least equal or better outcomes compared with older patients [9,10].…”

Section: Introductionmentioning

confidence: 97%

Comparable survival for young rectal cancer patients, despite unfavourable morphology and more advanced-stage disease

Orsini

Verhoeven

Lemmens

et al. 2015

European Journal of Cancer

View full text Add to dashboard Cite

Rectal Cancer in the Young Patient

Abstract: Patients younger than aged 40 years had a more advanced stage at the time of diagnosis and poor prognosis compared with older patients. Young patients treated for cure more often developed distant metastases and had inferior survival.

Cited by 43 publications

References 31 publications

Outcome of Rectal Cancer in Patients Aged 30 Years or Less in the Pakistani Population

Outcome of Rectal Cancer in Patients Aged 30 Years or Less in the Pakistani Population

Vascular Endothelial Growth Factors C and D Represent Novel Prognostic Markers in Colorectal Carcinoma Using Quantitative Image Analysis

Comparable survival for young rectal cancer patients, despite unfavourable morphology and more advanced-stage disease

Contact Info

Product

Resources

About