Rectal cancer recurrence: factors and mechanisms

Heriot,; Kumar, Vijay

doi:10.1046/j.1463-1318.2000.00148.x

Cited by 40 publications

(22 citation statements)

References 148 publications

(171 reference statements)

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“…Lymph node involvement is one of the most important factors in determining the prognosis of patients with rectal cancer [15][16][17]. Inadequate removal of tumor cells in lymphatic vessels and/or lymph nodes can contribute to the development of recurrence after curative-intent surgery [15,17,18].…”

Section: Discussionmentioning

confidence: 99%

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Distribution and patterns of lymph nodes metastases and micrometastases in the mesorectum of rectal cancer

Zheng

Zhou

et al. 2007

Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 99%

“…Inadequate removal of tumor cells in lymphatic vessels and/or lymph nodes can contribute to the development of recurrence after curative-intent surgery [15,17,18]. The implementation of TME in recent two decades has improved local control and functional control considerably [2][3][4][5]12].…”

Section: Discussionmentioning

confidence: 99%

Distribution and patterns of lymph nodes metastases and micrometastases in the mesorectum of rectal cancer

Zheng

Zhou

et al. 2007

Journal of Surgical Oncology

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“…The expected percentage of local recurrence varying from 3% to 32% in different studies [4,5]. Also, factors that control the degree of local recurrence include tumor stage, grade and the rightadministration ofappropriate treatment [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Imaging in Assessment of Recurrent Rectal Malignancy in Iraqi Patients

2017

IJSR

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Background: The incidence of colorectal cancer has been increasing dramatically following thefinancial and economic advancements. Now, colorectal cancer is the third foremost cause of cancer deaths in both males and femalesin the United States.Many diagnostic tools had been emerging in the screening and early diagnosis of the disease including fecal occult blood and colonoscopy, but from a radiological viewpoint; Magnetic Resonance (MR) imaging is still by far the primary cross-sectional imaging modality used for preoperative local staging of rectal cancer, patient-follow up after rectal surgery and neoadjuvant chemotherapy due to its high spatial resolution and marked soft-tissue characterization. Objective: The objective of this studyis to assess the role of MR imaging in recurrent rectal tumor detection, its site, signal characteristics and appearance on variable sequences and whether or not the tumor is resectable. Patients and method: This is a retrospective study compromised of 50 patients; it was performed during the period of November 2016 to September 2017 in MR unit in the Oncology Teaching Hospital, Medical City Compound, where the patients were referred from the Oncology Clinic then their imaging findings were assessed by specialist radiologists. Results: A review of the study that compromised of 50 patients with rectal cancer and underwent surgery; 20 were males and 30 were females, their age ranges between 28-85 years, 12 patients (24%) showed no recurrence while the remaining 38 patients (76%) showed recurrence. However, ofthe recurrent tumor patients; 12 had recurrence at ileoanal anastomosis site in which 5 had intramural (41%), 5 hadextraluminal (41%) and 2 patients had both intra-and extramural recurrence. While in patients with abdominoperineal resection; 9 had anterior local recurrence (34.6%) and 7 cases of presacral regrowth were found (27%) ,only 3 patients showed lateral pelvic wall muscular invasion (11.5%). Also, lymph nodes recurrence was found in 7 patients mainly involving the mesorectal group (57%). The obturator group involved in (28%) and least infiltrated nodes were the inguinal group in (15%). The results of the MR signal in corresponding to nearby pelvic muscles on T1 and T2 weighted images were isointense in 68% and greater than in 32%, while the enhancement pattern after intravenous Gadolinium is equal to ileum wall enhancement in 76% and greater than in 24%. Conclusion: MR imaging is thepreferred imaging modality inevaluation and patient-follow up with suspicious recurrence after rectal malignancy surgery.Its value was demonstrated in characterization and diagnosis of pelvis lesion(s) by assessing their appearance on T1,T2 and fat suppression T2 MR sequences, as well as assessing their enhancement pattern after intravenous Gadolinium in fat suppression sequence.

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“…The incidence after radical operation ranges from 2.6 to 32.0% and it has a very poor prognosis 1,2 . In patients with total mesorectal excision and an achieved negative radial resection margin (circumferential resection margin) local recurrence is less than 10%.…”

Section: Introductionmentioning

confidence: 99%

Laparoscopic abdominoperineal resection with intraoperative radiotherapy for locally advanced low rectal cancer

Škrovina

Soumarová²,

Duda³

et al. 2014

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Rectal cancer recurrence: factors and mechanisms

Cited by 40 publications

References 148 publications

Distribution and patterns of lymph nodes metastases and micrometastases in the mesorectum of rectal cancer

Distribution and patterns of lymph nodes metastases and micrometastases in the mesorectum of rectal cancer

Magnetic Resonance Imaging in Assessment of Recurrent Rectal Malignancy in Iraqi Patients

Laparoscopic abdominoperineal resection with intraoperative radiotherapy for locally advanced low rectal cancer

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