Rectal carcinoid tumor metastasis to a skull base meningioma

Bhojwani, Nicholas; Huang, Jennifer; Gupta, Amit; Badve, Chaitra; Cohen, Mark L.; Wolansky, Leo

doi:10.1177/1971400915624113

Cited by 9 publications

(4 citation statements)

References 8 publications

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“…Lung and breast carcinoma appear as the origin of metastases in numerous cases [6,16,22]. To our knowledge, only two cases of neuroendocrine neo-plasm metastasis to a meningioma were reported in the literature [3,20]; in both cases clinical symptoms of systemic cancer appeared previously to TTMM occurrence. As far as we know, this is the first case report of TTMM as a primary manifestation of neuroendocrine cancer.…”

Section: Discussionmentioning

confidence: 90%

Clinical presentation of neuroendocrine cancer metastasis to an anterior clinoid process meningioma invading superior orbital fissure. A case report

Rzehak¹,

Sobstyl²,

Wierzba-Bobrowicz³

et al. 2021

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Metastasis to a meningioma is an uncommon phenomenon however reported in the literature. Meningiomas are common primary intracranial tumours which most frequently occur to be a recepient of metastases. A 66-yearold female presented with rapid development of visual acuity and visual field loss in the right eye with ipsilateral oculomotor nerve palsy. Magnetic resonance imaging (MRI) showed well-defined tumour intensely enhanced with contrast like a typical skull base meningioma. The neuropathological examination revealed two different morphological fragments of the tumour. In the cell-rich part of the tumour, immunopositivity for CK, chromogranin, and SY were detected. The less cellular portion of the tumour, immunopositivity to epithelial membrane antigen (EMA) and vimentin were detected. To our knowledge, we present the first rare metastasis of neuroendocrine carcinoma to the medial sphenoid meningioma that preceded the clinical symptoms of systemic neuroendocrine carcinoma.

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Section: Discussionmentioning

confidence: 90%

Clinical presentation of neuroendocrine cancer metastasis to an anterior clinoid process meningioma invading superior orbital fissure. A case report

Rzehak¹,

Sobstyl²,

Wierzba-Bobrowicz³

et al. 2021

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“…[ 4 - 6 ] There is a report of a NET metastasizing to the meningioma itself. [ 1 ] This case also had the possibility of NET metastasis to the vestibular schwannoma, but histopathological examination did not reveal any evidence of it. In any case, in patients with a history of a NET, a careful follow-up is advisable even for lesions highly suspected to be vestibular schwannomas or meningiomas on MRI.…”

Section: Discussionmentioning

confidence: 98%

Cerebellopontine angle metastasis of a neuroendocrine tumor mimicking vestibular schwannoma: A case report

Yamada

Kijima

Kinoshita

et al. 2022

Surgical Neurology International

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Background: Neuroendocrine tumors (NETs) are uncommon neoplasms arising from neuroendocrine cells and are rarely associated with intracranial metastases. Case Description: We discuss the case of a 74-year-old woman with a right CPA tumor. She had a history of retroperitoneal NET, but was diagnosed with vestibular schwannoma due to a right-sided hearing loss and a right CPA tumor along the VII and VIII nerves. After a 3-year follow-up, she presented with repetitive vomiting, a 1-month history of gait instability, and a 3-month history of general fatigue. Brain imaging revealed tumor growth and edematous changes in the right cerebellum. She underwent retrosigmoid craniotomy and partial resection. Histopathological examination revealed metastatic NET. She underwent stereotactic radiosurgery for residual lesion and, at 11 months of follow-up, the lesion was confirmed to have shrunk on magnetic resonance imaging (MRI). Conclusion: This is the first case to report the natural course of cerebellopontine metastasis of a NET. The differential diagnosis of CPA tumors is diverse, and, in our case, we suspected a vestibular schwannoma because of the typical symptoms and imaging features. However, the tumor grew relatively faster than expected and showed intratumoral hemorrhage during the 3-year follow-up. Therefore, in patients with a history of a NET, a careful follow-up is advisable even for lesions highly suspected to be another benign tumor on MRI. Careful follow-up imaging and appropriate treatment strategies were useful to manage the brain metastasis. Although NETs metastasizing to the CPA are extremely rare, this possibility should be considered when patients with NETs have intracranial lesions.

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“…Although meningiomas show characteristic findings, a faster than expected growth suggests that they may originate from metastatic disease (3). A study correlating meningioma growth with histology showed a mean doubling time of 415 days (range, 138-1045 days) in benign, 178 days (34-551 days) in atypical, and 205 days (30-472 days) in anaplastic meningiomas (8).…”

Section: █ Discussionmentioning

confidence: 99%

Metastatic gallbladder carcinoma in meningioma: a case report

Eren¹,

Güzey²,

Güleç³

et al. 2017

Turkish Neurosurgery

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Metastases from tumors to systemic cancers are rare. The most common intracranial recipient tumor is meningioma. Metastasis from gallbladder cancer has been previously reported from only one patient during autopsy. We present the case of a 72-year-old woman who underwent surgery for right frontal skull base meningioma.The tumor was completely removed. Histological specimens showed gallbladder carcinomatous metastasis with diffuse neuroendocrine differentiation in meningothelial meningioma. The Ki-67 proliferation index of the meningioma was 3%. Further, 60% positive immunoreactivity with the progesterone receptor was observed in meningioma cells. In carcinoma cells, diffuse positive immunoreactivity with chromogranin, CDX2, CEA, panCK, cytokeratin 7, and synaptophysin was observed. A combination of molecular, metabolic, immunological, and/or hormonal factors may contribute to the pathogenesis of this lesion. It cannot be ruled out that it is more common than expected.

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Rectal carcinoid tumor metastasis to a skull base meningioma

Cited by 9 publications

References 8 publications

Clinical presentation of neuroendocrine cancer metastasis to an anterior clinoid process meningioma invading superior orbital fissure. A case report

Clinical presentation of neuroendocrine cancer metastasis to an anterior clinoid process meningioma invading superior orbital fissure. A case report

Cerebellopontine angle metastasis of a neuroendocrine tumor mimicking vestibular schwannoma: A case report

Metastatic gallbladder carcinoma in meningioma: a case report

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