Rectal misoprostol versus intravenous oxytocin for prevention of postpartum hemorrhage

Nasr, Ahmed; Shahin, Ahmed Y.; Elsamman, Ali M.; Zakherah, Mahmoud S.; Shaaban, Omar M.

doi:10.1016/j.ijgo.2009.01.018

Cited by 36 publications

(16 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present trial, no differences in the number of cases of PPH and additional oxytocin usage were observed. This finding is in keeping with several other studies [8,12,14,15,20–22]. However, a WHO multicenter randomized trial [10] found a significant difference: 20% of women given misoprostol had a measured blood loss of at least 500 mL, compared with 14% of those given oxytocin (RR 1.44, 95% CI 1.35–1.54; P < 0.001).…”

Section: Discussionsupporting

confidence: 88%

“…Shivering, pyrexia, and diarrhea were the most common adverse effects in the present study and were significantly more prevalent among women in the misoprostol group. This is a common finding in many studies that have compared misoprostol with oxytocin [8–10,14,15,18,20–23], although Afolabi et al [13] reported no rise in temperature between the pre‐intervention and post‐intervention periods in either group in their study in Ile‐Ife, Nigeria. The pathogenesis of shivering and pyrexia associated with misoprostol is related to a prostaglandin‐mediated shift in the hypothalamic set point of the thermoregulatory pathway.…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Double‐blind randomized controlled trial comparing misoprostol and oxytocin for management of the third stage of labor in a Nigerian hospital

Musa

Ijaiya

Saidu

et al. 2015

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 92%

Double‐blind randomized controlled trial comparing misoprostol and oxytocin for management of the third stage of labor in a Nigerian hospital

Musa

Ijaiya

Saidu

et al. 2015

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…The risk of bias was assessed independently by LH and AW for 14 trials [10][11][12][13][14][15][16][17][18][19][20][21][22][23]. Six assessments [24][25][26][27][28][29] were produced during a review by Gallos et al [30]. [47].…”

Section: Risk Of Bias Of Included Trialsmentioning

confidence: 99%

Postpartum haemorrhage (PPH) rates in randomized trials of PPH prophylactic interventions and the effect of underlying participant PPH risk: a meta-analysis

Hawker

Weeks

2020

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

Background: Postpartum haemorrhage (PPH) remains a leading cause of maternal mortality. Many trials assessing interventions to prevent PPH base their data on low risk women. It is important to consider the impact data collection methods may have on these results. This review aims to assess trials of PPH prophylaxis by grading trials according to the degree of risk status of the population enrolled in these trials and identify differences in the PPH rates of low risk and high risk populations. Methods: Systematic review and meta-analysis using a random-effects model. Trials were identified through CENTRAL. Trials were assessed for eligibility then graded according to antenatal risk factors and method of birth into five grades. The main outcomes were overall trial rate of minor PPH (blood loss ≥500 ml) and major PPH (> 1000 ml) and method of determining blood loss (estimated/measured).

show abstract

“…In an Egyptian study it was shown that routine use of 800 microgram of rectal misoprostol was effective in reducing blood loss after delivery. 10 The major advantages of utilizing rectal misoprostol include its ease of administration, low side effect profile and its ability to be administered in patients experiencing vomiting during intrapartum period. 11 In our country, the rate of caesarean delivery is increasing, so reduction of blood loss at caesarean section is beneficial to the patients in terms of decreased postoperative morbidity and a decrease in risks associated with blood transfusion.…”

Section: Mediscopementioning

confidence: 99%

Randomized controlled trial of three oxytocic regimens to prevent primary postpartum haemorrhage at caesarean section

2017

View full text Add to dashboard Cite

The objective of this present study was to compare the efficacy of three oxytocic regimens to prevent primary postpartum haemorrhage (PPH) at caesarean section. A randomized controlled trial including 90 patients who underwent caesarean section were selected according to inclusion and exclusion criteria assigned randomly into three groups (30 patients in each group) was conducted. Group 1 and group 2 were exposure groups and group 3 was control group. All patients were given 10 units intravenous (IV) bolus oxytocin immediately after delivery of baby. Group 1 was given additional 20 units oxytocin in each 1000 ml fluid for 24 hours. Group 2 received additional 1000 microgram misoprostol per rectal. Group 3 did not receive any additional oxytocic drug. Background characteristics of all the three groups were similar. It was observed that 501-1000 ml blood loss was found among 25 (83.3%) cases in group 1, 27 (90.0%) in group 2 and 27 (90.0%) in group 3. The mean (SD) amount of blood loss was found 733 (190) ml in group 1792 (187) ml in group 2 and 818 (14) ml in group 3. Occurrence of PPH and blood transfusion needed among 1 (3.3%) in group 1, 2 (6.7%) in group 2 and 3 (10.0%) in group 3. Side effects occurred in 7 (23.3%) patients of group 1, 18 (60.0%) in group 2, and 6 (20.0%) in group 3. Shivering was found among 4 (13.3%) in group 1, 10 (33.3%) in group 2 and 3 (10%) in group 3. Vomiting was found among 2 (6.7%) in group 1, 4 (13.3%) in group 2, and 2 (6.7%) in group 3. Pyrexia was 1 (3.3%) in group 1, 4 (13.3%) in group 2 and 1 (3.3%) in group 3. Side effects were more in the group where misoprostol was used. Except side effects there was no statistical difference of occurrence of different events among the three groups. Only bolus IV oxytocin appears to be as effective as oxytocin infusion in addition to bolus IV oxytocin or per rectal misoprostol in addition to bolus IV oxytocin to prevent primary PPH at caesarean section. But occurrence of transient side effects such as shivering, pyrexia and vomiting were noted more frequently with the use of misoprostol.Mediscope Vol. 4, No. 2: Jul 2017, Page 5-11

show abstract

Rectal misoprostol versus intravenous oxytocin for prevention of postpartum hemorrhage

Abstract: Routine use of 800 microg of rectal misoprostol was effective in reducing blood loss after delivery. We recommend the regimen for low-resource, busy obstetric settings.

Cited by 36 publications

References 24 publications

Double‐blind randomized controlled trial comparing misoprostol and oxytocin for management of the third stage of labor in a Nigerian hospital

Double‐blind randomized controlled trial comparing misoprostol and oxytocin for management of the third stage of labor in a Nigerian hospital

Postpartum haemorrhage (PPH) rates in randomized trials of PPH prophylactic interventions and the effect of underlying participant PPH risk: a meta-analysis

Randomized controlled trial of three oxytocic regimens to prevent primary postpartum haemorrhage at caesarean section

Contact Info

Product

Resources

About