Rectal morbidity after permanent prostate brachytherapy with dose escalation to biologic target volumes identified by SPECT/CT fusion

Ten-Year Outcomes: The Clinical Utility of Single Photon Emission Computed Tomography/Computed Tomography Capromab Pendetide (Prostascint) in a Cohort Diagnosed With Localized Prostate Cancer

“…Presenting baseline rectal, urinary, and erectile functions were prospectively assessed at the time of initial clinical evaluation, in the majority of the cohort, to monitor for potential acute and chronic treatment-related toxicity. As previously described in detail, our SPECT/CT BTV IGRT-DE protocol demonstrated limited and acceptable toxicity for the cohort (11)(12)(13).…”

“…Neither conventional CaP imaging nor any other staging method, including PLND studies in 65 patients (27.2%), could confirm the presence of distant metastatic uptake suggested by SPECT/CT (mets). Therefore, these findings were assumed to represent probable false positive results; and all subjects were followed without alteration in disease management; as previously described in detail (10)(11)(12)(13).…”

“…SPECT/CT BTV localization, treatment planning, and radiotherapy were performed by a single radiation oncologist (R.J.E. ), as previously reported (10)(11)(12)(13).…”

“…SPECT/CT-determined periprostatic and/or intraprostatic BTV locations were manually transferred to TRUS images for IGRT-DE preplanning. IGRT-DE to BTV preplanning was achieved via brachytherapy by directing the additional placement of radioactive seeds to BTV regions as determined by antibody uptake on SPECT/CT image sets, as previously described in detail (10)(11)(12)(13).…”

Technological Development and Advances in Single-Photon Emission Computed Tomography/Computed Tomography

“…(Adapted and reproduced permission of reference [115].) Anatomic localization, evaluation of therapeutic efficacy for pancreatic chemotherapy [180,[191][192][193] Parathyroid gland 99m Tc-sestamibi Anatomical localization [161,[194][195][196][197][198] Pheochromocytoma 123 I-metaiodobenzylguanidine Anatomical localization [189] Prostate cancer 111 In-capromab pendetide Attenuation correction, anatomical localization, monitoring brachytherapy [12,26,[199][200][201][202][203][204] Whole body (phantom study) Technetium-99m Attenuation correction, radioimmunotherapy dosimetry [226] …”