Rectal Polyps and Other Neoplasms

Association of Primary Tumor Site With Mortality in Patients Receiving Bevacizumab and Cetuximab for Metastatic Colorectal Cancer

“…Colorectal cancers (CRCs) are molecularly heterogeneous with carcinogenic pathways that are, in part, associated with embryologic origin. The right side of the colon, anatomically defined from the cecum through the proximal two-thirds of the transverse colon, develops embryonically from the midgut, whereas the left colon, the distal one-third of transverse colon through the rectum, arises from the hindgut . Increasing evidence demonstrates that right- and left-sided CRCs have distinct genomic patterns owing to genetic and epigenetic alterations.…”