Rectal progesterone in ART cycles as luteal phase support, is it efficient?

Abstract

Assisted reproductive cycles have been associated with deficient luteal phase which was extensively researched. Progestogens can be given IM, SC, orally, rectally, transdermal or vaginally. Although progesterone supplementation represents the most preferable drugs for luteal phase support in fresh cycles, there is still debate which is the best time, dose and route for administration. Vaginal route is the most used in the luteal phase. Some of the clients who are using vaginal progesterone reports uncomfortable. We tried to review whether the rectal progesterone could be effective as luteal phase support and tolerable with less discomfort or not.