Rectal Prolapse Associated with Recurrent Diarrhea in a Laboratory Cynomolgus Monkey (<i>Macaca fascicularis</i>)

Lee, Sang-Rae; Lee, Yong-Hoon; Kim, Kyoung-Min; Kim, Sung Woo; Jung, Kang-Jin; Kim, Younghyun; Son, Hyeon-Taek; Chang, Kyu‐Tae

doi:10.5625/lar.2010.26.4.429

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…Diarrhea, tenesmus, and parturition are risk factors. 154 Intermittent or recent prolapse may be identified at necropsy as a dark red, edematous region of rectum/distal colon within the pelvis/caudal abdomen because of intermittent compromise to venous return. Persistent prolapse may result in complete devitalization of the bowel with full-thickness necrosis and is easily recognizable at gross necropsy.…”

Section: Noninfectious Causes Of Gastrointestinal Tract Lesions In Ma...mentioning

confidence: 99%

Common and Not-So-Common Pathologic Findings of the Gastrointestinal Tract of Rhesus and Cynomolgus Macaques

et al. 2022

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Rhesus and cynomolgus macaques are the most frequently used nonhuman primate (NHP) species for biomedical research and toxicology studies of novel therapeutics. In recent years, there has been a shortage of laboratory macaques due to a variety of competing factors. This was most recently exacerbated by the surge in NHP research required to address the severe acute respiratory syndrome (SARS)-coronavirus 2 pandemic. Continued support of these important studies has required the use of more varied cohorts of macaques, including animals with different origins, increased exposure to naturally occurring pathogens, and a wider age range. Diarrhea and diseases of the gastrointestinal tract are the most frequently occurring spontaneous findings in macaques of all origins and ages. The purpose of this review is to alert pathologists and scientists involved in NHP research to these findings and their impact on animal health and study endpoints, which may otherwise confound the interpretation of data generated using macaques.

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Section: Noninfectious Causes Of Gastrointestinal Tract Lesions In Ma...mentioning

confidence: 99%

Common and Not-So-Common Pathologic Findings of the Gastrointestinal Tract of Rhesus and Cynomolgus Macaques

et al. 2022

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“…Predisposing factors include intestinal inflammation from bacteria, parasites, rectal trauma, neoplasia of the rectum or distal colon, urolithiasis, urethral obstruction, cystitis and dystocia [32]. Prolapse of the rectum has been reported in many domestic, wild and laboratory animals, including dogs, cats, ferrets, cattle, horses, ewes, pigs, rodents, marsupials and macaque monkeys with recurrent diarrhoea [5,6,8,9,33]. Rectal prolapse is a common clinical condition in laboratory animals especially in mice under different settings that are highly influenced by the genotype, extent of intestinal inflammation, underlying neoplastic process or exposure to intestinal toxic insults such as DSS/AOM treatments [34].…”

Section: Discussionmentioning

confidence: 99%

Helicobacter monodelphidis sp. nov. and Helicobacter didelphidarum sp. nov., isolated from grey short-tailed opossums (Monodelphis domestica) with endemic cloacal prolapses

Shen

Mannion

Lin

et al. 2020

International Journal of Systematic and Evolutionary Microbiology

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In a search for potential causes of increased prolapse incidence in grey short-tailed opossum colonies, samples from the gastrointestinal tracts of 94 clinically normal opossums with rectal prolapses were screened for Helicobacter species by culture and PCR. Forty strains of two novel Helicobacter species which differed from the established Helicobacter taxa were isolated from opossums with and without prolapses. One of the Helicobacter species was spiral-shaped and urease-negative whereas the other Helicobacter strain had fusiform morphology with periplasmic fibres and was urease-positive. 16S rRNA gene sequence analysis revealed that all the isolates had over 99 % sequence identity with each other, and were most closely related to Helicobacter canadensis . Strains from the two novel Helicobacter species were subjected to gyrB and hsp60 gene and whole genome sequence analyses. These two novel Helicobacter species formed separate phylogenetic clades, divergent from other known Helicobacter species. The bacteria were confirmed as novel Helicobacter species based on digital DNA–DNA hybridization and average nucleotide identity analysis of their genomes, for which we propose the names Helicobacter monodelphidis sp. nov. with the type strain MIT 15-1451T (=LMG 29780T=NCTC 14189T) and Helicobacter didelphidarum sp. nov with type strain MIT 17-337T (=LMG 31024T=NCTC 14188T)

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“…In captive primates, rectal prolapse occurs at various ages, whereas in wild primates, 9 of 10 have occurred in juveniles (L. Barrett and S.P. Henzi, pers.…”

Section: Discussionmentioning

confidence: 99%

“…Rectal prolapse has been observed more often in captive primates than in wild primates. Four wild chacma baboons ( P .…”

Section: Introductionmentioning

confidence: 99%

Complete rectal prolapse in wild anubis baboons (Papio anubis)

Taniguchi

Isbell

Bidner

et al. 2019

J of Medical Primatology

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Rectal prolapse is classified as either incomplete, which involves only the rectal mucosa, or complete, in which the full thickness of the rectum prolapses through the anus. 1 Rectal prolapse can result from various factors, including straining related to cystitis, chronic coughing, parasites and defecation disorders due to environmental or social distress. 1,2 Rectal prolapse has been observed more often in captive primates 3-7 than in wild primates. Four wild chacma baboons (P. ursinus) that had fed extensively on sour fig/ice plant (Carpobrotus spp.)and three wild mountain gorillas (Gorilla gorilla) that fed on Malabar spinach (Basella alba) developed rectal prolapses. In all but one (a gorilla), they spontaneously resolved within 1-2 days (L. Barrett and S.P. Henzi, pers. comm.). 2 Here, we report rectal prolapses in two wild anubis baboons (P. anubis) related to provisioning with maize, and capture.

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Rectal Prolapse Associated with Recurrent Diarrhea in a Laboratory Cynomolgus Monkey (Macaca fascicularis)

Cited by 6 publications

References 14 publications

Common and Not-So-Common Pathologic Findings of the Gastrointestinal Tract of Rhesus and Cynomolgus Macaques

Common and Not-So-Common Pathologic Findings of the Gastrointestinal Tract of Rhesus and Cynomolgus Macaques

Helicobacter monodelphidis sp. nov. and Helicobacter didelphidarum sp. nov., isolated from grey short-tailed opossums (Monodelphis domestica) with endemic cloacal prolapses

Complete rectal prolapse in wild anubis baboons (Papio anubis)

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