Rectal Sucralfate in Radiation Proctitis

Kochhar, Rakesh; Sharma, Suresh C.; Gupta, Bhumika; Mehta, Shailender

doi:10.1016/s0140-6736(88)92874-7

Cited by 69 publications

(34 citation statements)

References 2 publications

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“…It has also been reported to increase epidermal growth factor binding to ulcerated areas and to stimulate macrophage activity. In addition, sucralfate seems to stimulate endogenous sulfhydryl compounds, protect vascular integrity of the mucosa and stimulate cell restitution and cell prolifertion at the microscopic level (6,(10)(11)(12). According to clinical observations sucralfate promotes healing of radiationinduced ulcers and oedema as observed in our earlier studies on radiation proctitis (6, 7) and also reported by other authors (13,14).…”

Section: Discussionsupporting

confidence: 77%

Oral Sucralfate in Acute Radiation Oesophagitis

1994

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Section: Discussionsupporting

confidence: 77%

Oral Sucralfate in Acute Radiation Oesophagitis

1994

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“…Both are well conducted with definitive outcomes of response and show a benefit for the use of rectal sucralfate for a period of 4 months and oral pentosan for 1 year, respectively. Of the retrospective reports (four describe the use of rectal sucralfate as a case report (Kochhar et al, 1988), and series of three, eight and three patients respectively (Ladas and Raptis, 1989;Kochhar et al, 1990;Stockdale and Biswas, 1997). All showed a benefit in both clinical and mucosal outcome, although the majority of these were not graded or scored to demonstrate significant differences.…”

Section: Studies Using Sucralfate and Pentosan Polysulphatementioning

confidence: 99%

Systematic review for non-surgical interventions for the management of late radiation proctitis

et al. 2002

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Chronic radiation proctitis produces a range of clinical symptoms for which there is currently no recommended standard management. The aim of this review was to identify the various non-surgical treatment options for the management of late chronic radiation proctitis and evaluate the evidence for their efficacy. Synonyms for radiation therapy and for the spectrum of lower gastrointestinal radiation toxicity were combined in an extensive search strategy and applied to a range of databases. The included studies were those that involved interventions for the non-surgical management of late radiation proctitis. Sixtythree studies were identified that met the inclusion criteria, including six randomised controlled trials that described the effects of anti-inflammatory agents in combination, rectal steroids alone, rectal sucralfate, short chain fatty acid enemas and different types of thermal therapy. However, these studies could not be compared. If the management of late radiation proctitis is to become evidence based, then, in view of its episodic and variable nature, placebo controlled studies need to be conducted to clarify which therapeutic options should be recommended. From the current data, although certain interventions look promising and may be effective, one small or modest sized study, even if well-conducted, is insufficient to implement changes in practice. In order to increase recruitment to trials, a national register of cases with established late radiation toxicity would facilitate multi-centre trials with specific entry criteria, formal baseline and therapeutic assessments providing standardised outcome data.

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“…Other pilot studies indicate that sucralfate may be helpful in reducing or preventing the radiation induced toxicity of the mucosal lining in the lower intestinal tract (11,12).…”

Section: A Prospective Pilot Study On the In Reducing Stomatitis Durimentioning

confidence: 99%