Rectify the Injury-Induced Microenvironment Imbalance in Peripheral Nerve Repair

Yan, Zhiwen; Qian, Yun

doi:10.5185/amlett.2020.101562

Cited by 3 publications

(2 citation statements)

References 21 publications

(26 reference statements)

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“…The ideal functional NGCs require physico-chemical cues and biological cues to synergistically construct a biomimetic microenvironment and maintain physiological balance for nerve repair [ 122 ]. The emerging 3D printing technology with design flexibility, personalized customization and controllable manufacturing precision is an advanced method to achieve the functionalization of NGCs.…”

Section: Discussionmentioning

confidence: 99%

3D printing of functional nerve guide conduits

Huang

Liu

et al. 2021

Burns &Amp; Trauma

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Nerve guide conduits (NGCs), as alternatives to nerve autografts and allografts, have been widely explored as an advanced tool for the treatment of peripheral nerve injury. However, the repairing efficiency of NGCs still needs significant improvements. Functional NGCs that provide a more favorable microenvironment for promoting axonal elongation and myelination are of great importance. In recent years, 3D printing technologies have been widely applied in the fabrication of customized and complex constructs, exhibiting great potential for tissue engineering applications, especially for the construction of functional NGCs. In this review, we introduce the 3D printing technologies for manufacturing functional NGCs, including inkjet printing, extrusion printing, stereolithography-based printing and indirect printing. Further, we summarize the current methods and strategies for constructing functional NGCs, such as designing special conduit architectures, using appropriate materials and co-printing with different biological cues. Finally, the challenges and prospects for construction of functional NGCs are also presented.

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Section: Discussionmentioning

confidence: 99%

3D printing of functional nerve guide conduits

Huang

Liu

et al. 2021

Burns &Amp; Trauma

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“…However, such regeneration process is often mistakenly thought to occur robustly and successfully ( Scheib and Höke, 2013 ). Hence, the complex biological events induced by the injury lead to changes in the biochemical and mechanical properties of the nerve tissue microenvironment, impairing the restoration of nerve function ( Yan and Qian, 2020 ; Qian et al, 2021c ). Therefore, it is of tremendous biomedical interest to improve current strategies to regenerate peripheral nerves more efficiently, especially in nerve defect models.…”

Section: Peripheral Nerve Damage and Regenerationmentioning

confidence: 99%

Two-Dimensional Nanomaterials for Peripheral Nerve Engineering: Recent Advances and Potential Mechanisms

Yan

Chen

Rosso

et al. 2021

Front. Bioeng. Biotechnol.

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Peripheral nerve tissues possess the ability to regenerate within artificial nerve scaffolds, however, despite the advance of biomaterials that support nerve regeneration, the functional nerve recovery remains unsatisfactory. Importantly, the incorporation of two-dimensional nanomaterials has shown to significantly improve the therapeutic effect of conventional nerve scaffolds. In this review, we examine whether two-dimensional nanomaterials facilitate angiogenesis and thereby promote peripheral nerve regeneration. First, we summarize the major events occurring after peripheral nerve injury. Second, we discuss that the application of two-dimensional nanomaterials for peripheral nerve regeneration strategies by facilitating the formation of new vessels. Then, we analyze the mechanism that the newly-formed capillaries directionally and metabolically support neuronal regeneration. Finally, we prospect that the two-dimensional nanomaterials should be a potential solution to long range peripheral nerve defect. To further enhance the therapeutic effects of two-dimensional nanomaterial, strategies which help remedy the energy deficiency after peripheral nerve injury could be a viable solution.

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