Recuperative effect of metformin loaded polydopamine nanoformulation promoting EZH2 mediated proteasomal degradation of phospho-α-synuclein in Parkinson’s disease model

Sardoiwala, Mohammed Nadim; Srivastava, Anup; Kaundal, Babita; Karmakar, Surajit; Choudhury, Subhasree Roy

doi:10.1016/j.nano.2019.102088

Cited by 39 publications

(57 citation statements)

References 51 publications

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“…From the perspective of cell morphology, a large number of apoptotic and senescent chondrocytes are the main cytological features of OA 35,36 . Extensive studies have documented that mitophagy leads to several diseases progression, including cancer 37 , neurodegenerative diseases 38 and cardiovascular disease 39 . Here, we sought to establish the potential role of HIF-1α-mediated mitophagy in eliminating dysfunctional mitochondria and its impact on remitting apoptosis and senescence in chondrocyte induced by hypoxia condition.…”

Section: Discussionmentioning

confidence: 99%

Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy

Zhang

et al. 2020

Cell Death Dis

133

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Mitochondrial dysfunction leads to osteoarthritis (OA) and disc degeneration. Hypoxia inducible factor-1α (HIF-1α) mediated mitophagy has a protective role in several diseases. However, the underlying mechanism of HIF-1α mediated mitophagy in OA remains largely unknown. This current study was performed to determine the effect of HIF-1α mediated mitophagy on OA. Therefore, X-ray and tissue staining including HE staining, safranin O-fast green (S-O) and Alcian Blue were used to assess imageology and histomorphology differences of mouse knee joint. Transcriptional analysis was used to find the possible targets in osteoarthritis. Western blot analysis, RT-qPCR and immunofluorescence staining were used to detect the changes in gene and protein levels in the vitro experiment. The expression of HIF-1α was increased in human and mouse OA cartilage. HIF-1α knockdown by siRNA further impair the hypoxia-induced mitochondrial dysfunction; In contrast, HIF-1α mediated protective role was reinforced by prolylhydroxylase (PHD) inhibitor dimethyloxalylglycine (DMOG). In addition, HIF-1α stabilization could alleviate apoptosis and senescence via mitophagy in chondrocytes under hypoxia condition, which could also ameliorate surgery-induced cartilage degradation in mice OA model. In conclusion, HIF-1α mediated mitophagy could alleviate OA, which may serve as a promising strategy for OA treatment.

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Section: Discussionmentioning

confidence: 99%

Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy

Zhang

et al. 2020

Cell Death Dis

133

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Section: Nano-dds Of Met For Neuroprotectionmentioning

confidence: 99%

“…Additionally, MET has also been found to possess the therapeutic activity in the treatment of Parkinson's disease (Sardoiwala et al 2020). It has been found that Parkinson's disease was highly correlated with the agglomeration of α-synuclein (α-Syn), oxidative stress, mitochondrial dysfunction and deficiency of dopaminergic neurons (Sardoiwala et al 2020). The neuroprotective effect of MET is contributed to its anti-inflammatory action, induction of autophagy and reduction of phosphorylated proteins involved agglomeration of α-synuclein (Sardoiwala et al 2020).…”

Section: Nano-dds Of Met For Neuroprotectionmentioning

confidence: 99%

“…It has been found that Parkinson's disease was highly correlated with the agglomeration of α-synuclein (α-Syn), oxidative stress, mitochondrial dysfunction and deficiency of dopaminergic neurons (Sardoiwala et al 2020). The neuroprotective effect of MET is contributed to its anti-inflammatory action, induction of autophagy and reduction of phosphorylated proteins involved agglomeration of α-synuclein (Sardoiwala et al 2020). Recently, Sardoiwala et al prepared a MET-loaded polydopamine nano-DDS for Parkinson's disease therapy by virtue of neuroprotection efficacy of MET (Sardoiwala et al 2020).…”

Section: Nano-dds Of Met For Neuroprotectionmentioning

confidence: 99%

“…The neuroprotective effect of MET is contributed to its anti-inflammatory action, induction of autophagy and reduction of phosphorylated proteins involved agglomeration of α-synuclein (Sardoiwala et al 2020). Recently, Sardoiwala et al prepared a MET-loaded polydopamine nano-DDS for Parkinson's disease therapy by virtue of neuroprotection efficacy of MET (Sardoiwala et al 2020). The neuroprotective efficiency of MET-loaded polydopamine nano-DDS was found to be related to downregulation of α-Syn, reduction in oxidative stress, prevention of apoptosis and anti-inflammatory effects (Sardoiwala et al 2020).…”

Section: Nano-dds Of Met For Neuroprotectionmentioning

confidence: 99%

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Emerging nanoparticulate drug delivery systems of metformin

Chen

Shan

Luo

et al. 2020

J. Pharm. Investig.

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Background Driving the conventional drug in new applications has emerged as a research hotspot for disease treatment. Metformin (MET) is conventionally used for the treatment of type II diabetes. It has also been found to be a versatile molecule with wide biological functions, such as losing weight. anti-aging and anticancer activity. Rational design of nanoparticulate drug delivery systems (nano-DDS) could significantly improve drug delivery efficiency. Recently, a wide range of nano-DDS has been developed to improve the delivery efficacy of MET or to perform as versatile nanoplatforms for efficient drug delivery. Area covered In this review, we outline the emerging trends in advanced nano-DDS of MET, focusing on nano-DDS of MET for diabetes therapy, nano-DDS of MET for anticancer therapeutics, and nano-DDS of MET for other therapeutic aims. Expert opinion Despite the great progression in nano-DDS of MET, there's still a long way to truly put the conventional drug in new applications. Several important issues should be fully taken into consideration, such the manufacturing cost and economic burdens for patients, the biocompatibility and long-term toxicity of carrier materials, scale-up preparation difficulties, as well as the species gap between human beings and animal models.

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Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise

et al. 2020

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Developing efficient, sustainable, and biocompatible high‐tech nanoplatforms derived from naturally existing components in living organisms is highly beneficial for diverse advanced biomedical applications. Melanins are nontoxic natural biopolymers owning widespread distribution in various biosystems, possessing fascinating physicochemical properties and playing significant physiological roles. The multifunctionality together with intrinsic biocompatibility renders bioinspired melanin‐like nanomaterials considerably promising as a versatile and powerful nanoplatform with broad bioapplication prospects. This panoramic Review starts with an overview of the fundamental physicochemical properties, preparation methods, and polymerization mechanisms of melanins. A systematical and well‐bedded description of recent advancements of melanin‐like nanomaterials regarding diverse biomedical applications is then given, mainly focusing on biological imaging, photothermal therapy, drug delivery for tumor treatment, and other emerging biomedicine‐related implementations. Finally, current challenges toward clinical translation with an emphasis on innovative design strategies and future striving directions are rationally discussed. This comprehensive and detailed Review provides a deep understanding of the current research status of melanin‐like nanomaterials and is expected to motivate further optimization of the design of novel tailorable and marketable multifunctional nanoplatforms in biomedicine.

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Recuperative effect of metformin loaded polydopamine nanoformulation promoting EZH2 mediated proteasomal degradation of phospho-α-synuclein in Parkinson’s disease model

Cited by 39 publications

References 51 publications

Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy

Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy

Emerging nanoparticulate drug delivery systems of metformin

Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise

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