Recurrence and survival for hepatocellular carcinoma after curative resection: Tertiary centre experience

Abstract

Aim:The aim of the present paper was to determine the pattern of recurrence and prediction for survival after primary curative surgical resection of hepatocellular carcinoma (HCC). Methods: This was a retrospective single institutional review. During 2002During -2005 patients had hepatectomies at Queen Elizabeth Hospital The total number of patients with primary curative liver resection was 113, and 103 patients were included in this survival analysis. Results: The recurrence rate was 49/103 (47.6%). The operative mortality rate was 4/113 (3.5%). The median time for recurrence was 13.5 months (range, 1-60 months). The mean follow-up period was 26.03 months (range, 1-60 months).Overall survival was 90%, 72% and 50%, at 1, 3 and 5 years, respectively, and diseasefree survival was 55%, 48% and 42%, at 1, 3 and 5 years, respectively. On univariate analysis, tumour > 10 cm, close (Յ 1 mm)/focally involved/involved resection margin, operative blood loss > 2500 mL, presence of satellite tumour nodules, vascular invasion and poor tumour differentiation were found to be associated with recurrence. On multivariate analysis presence of multiple satellite tumour nodules and presence of vascular invasion predicted poor disease-free survival whereas vascular invasion was the only predictor for overall survival. Conclusion: Patients who had curative surgical resection for HCC should be considered for adjuvant therapy when these high-risk factors are present.

Radiofrequency ablation for hepatocellular carcinoma: a survival analysis of 117 patients

“…Diagnosis of HCC was made according to the criteria described in our previous publication 4 . Diagnosis of HCC was made in the presence of diagnostic features on triphasic contrast computed tomography (CT) or magnetic resonance imaging (MRI) with an elevated level of alpha fetoprotein (αFP; >400 ng/mL).…”