Recurrence Following Anastomotic Leakage After Surgery for Carcinoma of the Distal Esophagus and Gastroesophageal Junction: A Systematic Review

Aurello, Paolo; Berardi, Giammauro; Moschetta, Giovanni; Cinquepalmi, Matteo; Antolino, Laura; Nigri, Giuseppe; D’Angelo, Francesco; Valabrega, Stefano; Ramacciato, Giovanni

doi:10.21873/anticanres.13270

Cited by 20 publications

(27 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Elderly esophageal cancer patients generally have co-morbidities and age-related physiological problems (6)(7)(8). Previous reports have shown that the postoperative surgical complication rates after esophagectomy are 30% to 70%, and the mortality rate is 1%-5% (9)(10)(11)(12). Given this situation, perioperative management might be difficult in elderly esophageal cancer patients.…”

mentioning

confidence: 99%

The Clinical Impact of the Age-adjusted Charlson Comorbidity Index on Esophageal Cancer Patients Who Receive Curative Treatment

Aoyama

Atsumi

Kawahara

et al. 2020

In Vivo

View full text Add to dashboard Cite

Background/Aim: We investigated the impact of the age-adjusted Charlson comorbidity index (ACCI) on esophageal cancer survival and recurrence after curative treatment. Patients and Methods: This study included 122 patients who underwent curative surgery followed by adjuvant chemotherapy for esophageal cancer between 2005 and 2017. The risk factors for the overall survival (OS) and recurrencefree survival (RFS) were identified. Results: An ACCI of 5 was regarded as the optimal critical point of classification considering the survival rates. The OS rates at 3 and 5 years after surgery were 64.2% and 54.4% in the low-ACCI group, respectively, and 42.3% and 29.2% in high-ACCI group, respectively (p=0.035). The RFS rates at 3 and 5 years after surgery were 50.2% and 43.6% in the low-ACCI group, respectively, and 28.5% and 21.3% in high-ACCI group, respectively (p=0.021). A multivariate analysis demonstrated that ACCI was a significant independent risk factor for both the OS and RFS. Conclusion: ACCI is a risk factor for survival in patients who undergo curative treatment for esophageal cancer. An effective plan for the perioperative care and surgical strategy should be developed according to ACCI. Esophageal cancer is the seventh-most common cancer and the sixth leading cause of cancer-related mortality. An 2783 This article is freely accessible online.

show abstract

mentioning

confidence: 99%

The Clinical Impact of the Age-adjusted Charlson Comorbidity Index on Esophageal Cancer Patients Who Receive Curative Treatment

Aoyama

Atsumi

Kawahara

et al. 2020

In Vivo

View full text Add to dashboard Cite

show abstract

“…The relationship between AL and long-term results after surgery for gastric cancer is still the subject of debate. Our group has recently published a review regarding the relationship between AL and oesophageal cancer, showing how, with a proper literature analysis, is it possible to highlight the relationship between AL and survival (17). A similar investigation was performed on colorectal surgery, concluding that AL after proctectomy for cancer is associated with worse long-term DFS and overall survival (18).…”

Section: Discussionmentioning

confidence: 98%

Impact of Anastomotic Leakage on Overall and Disease-free Survival After Surgery for Gastric Carcinoma: A Systematic Review

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background/Aim: Gastric cancer is the fifth most frequently diagnosed cancer and the second most common cause of cancer-related death. The only potentially curative treatment is surgical resection, which is associated with potentially severe complications, such as anastomotic leakage. The aim of this systematic review was to evaluate the relationship between anastomotic leakage and overall and disease-free survival after surgery for gastric cancer. Materials and Methods: A systematic literature search was performed and 7 articles published between 2010 and 2019 were included, including a total of 7,167 patients. Results: Among the included studies the frequency of anastomotic leakage ranged from 6 to 41%. Patients affected by anastomotic leakage had an overall survival ranging between 4.1 and 97.6 months, whereas patients who did not experience anastomotic leakage had an overall survival between 23 and 109.5 months. Conclusion: Closer follow-up or even more aggressive oncological therapy may be considered for patients affected by anastomotic leakage after surgery for gastric cancer.Gastric cancer is the fifth most frequently diagnosed cancer and the second most common cause of cancer-related death

show abstract

“…It has been demonstrated that major complications (CD ! IIIa) are associated with postponement of adjuvant therapy and worse oncological outcomes, like local recurrences and shortened recurrence-free survival [7,8]. The majority of studies addressing the prevention of postoperative complications have concentrated on operation-specific risk factors (e.g., anastomosis technique).…”

Section: Introductionmentioning

confidence: 99%

Preoperative risk factors for major postoperative complications after complex gastrointestinal cancer surgery: A systematic review

Kooten

Bahadoer

Peeters

et al. 2021

European Journal of Surgical Oncology

View full text Add to dashboard Cite

Patients undergoing complex gastrointestinal surgery are at high risk of major postoperative complications (e.g., anastomotic leakage, sepsis), classified as Clavien-Dindo (CD) ! IIIa. Identification of preoperative risk factors can lead to the identification of high-risk patients. These risk factors can also be used to design personalized perioperative care. This systematic review focuses on the identification of these factors. The Medline and Embase databases were searched for prospective, retrospective cohort studies and randomized controlled trials investigating the effect of risk factors on the occurrence of major postoperative complications and/or mortality after complex gastrointestinal cancer surgery. Risk of bias was assessed using the Quality in Prognostic Studies tool. The level of evidence was graded based on the number of studies reporting a significant association between risk factors and major complications. A total of 207 eligible studies were retrieved, identifying 33 risk factors for major postoperative complications and 13 preoperative laboratory results associated with postoperative complications. The present systematic review provides a comprehensive overview of preoperative risk factors associated with major postoperative complications. A wide range of risk factors are amenable to actions in perioperative care and prehabilitation programs, which may lead to improved outcomes for high-risk patients. Additionally, the knowledge of this study is important for benchmarking surgical outcomes.

show abstract

Recurrence Following Anastomotic Leakage After Surgery for Carcinoma of the Distal Esophagus and Gastroesophageal Junction: A Systematic Review

Cited by 20 publications

References 27 publications

The Clinical Impact of the Age-adjusted Charlson Comorbidity Index on Esophageal Cancer Patients Who Receive Curative Treatment

The Clinical Impact of the Age-adjusted Charlson Comorbidity Index on Esophageal Cancer Patients Who Receive Curative Treatment

Impact of Anastomotic Leakage on Overall and Disease-free Survival After Surgery for Gastric Carcinoma: A Systematic Review

Preoperative risk factors for major postoperative complications after complex gastrointestinal cancer surgery: A systematic review

Contact Info

Product

Resources

About