Recurrence in patients following curative resection of early gastric carcinoma

Wu, Bing; Wu, Dao-hong; Wang, Mengwei; Wang, Gangshi

doi:10.1002/jso.21133

Cited by 50 publications

(36 citation statements)

References 21 publications

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“…Early tumor recurrence has been associated with lymph node metastasis and a poor prognosis [7,16,17]. In our study we observed that tumor recurrence and prognosis of T1a (tumor invades mucosa) cancer were similar to those for T1b (tumor invades submucosa) cancer (p [ 0.05), and we identified lymph node metastasis as an independent risk factor for tumor recurrence, as well as an independent prognostic factor.…”

Section: Discussionsupporting

confidence: 67%

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Comparison the sixth and seventh editions of the AJCC staging system for T1 gastric cancer: a long-term follow-up study of 2124 patients

Choi

Kim

et al. 2016

Gastric Cancer

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Background/Aim The aim of this study was to establish an appropriate TNM staging system for early gastric cancer. Methodology We evaluated 2124 patients who had undergone gastrectomy for early gastric cancer between 1989 and 2001. Results Using the seventh edition of the American Joint Committee on Cancer (AJCC) staging system, we found no significant differences in tumor recurrence and survival between N1 and N2 cancers or between N3a and N3b cancers, whereas the survival curves for N2 and N3 cancers were quite different. Similarly, using the classification in the sixth edition of the AJCC staging system, we found no significant difference in survival between the N2 and N3 cancer groups, whereas the survival curves for N1 versus N2 or N3 cancers were quite different. Conclusions The classifications in the sixth and seventh editions of the AJCC staging system have a limitation for T1 gastric cancer (early gastric cancer).

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Section: Discussionsupporting

confidence: 67%

“…The survival rate of patients with EGC exceeds 90 % in Japan [3,4] and in Western countries [5]. Variable rates of recurrence of EGC have been reported in these countries, ranging from 2.1 to 12.4 % [6][7][8]. The seventh edition of the American Joint Committee on Cancer (AJCC) staging system was published in 2010.…”

Section: Introductionmentioning

confidence: 99%

Comparison the sixth and seventh editions of the AJCC staging system for T1 gastric cancer: a long-term follow-up study of 2124 patients

Choi

Kim

et al. 2016

Gastric Cancer

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“…Age, lymphatic metastasis and submucosal invasion have been reported to be significantly associated with recurrence of gastric cancer [25] . In the current study, only 5% (4/80) of patients with early gastric cancer experienced early recurrence.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with early recurrence after curative surgery for gastric cancer

Kang¹,

Meng²,

Yu³

et al. 2015

WJG

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AIM:To characterize patterns of gastric cancer recurrence and patient survival and to identify predictors of early recurrence after surgery. METHODS:Clinicopathological data for 417 consecutive patients who underwent curative resection for gastric cancer were retrospectively analyzed. Tumor and node status was reclassified according to the 7 th edition of the American Joint Committee on Cancer tumor-node-metastasis classification for carcinoma of the stomach. Survival data came from both the patients' follow-up records and telephone followups. Recurrent gastric cancer was diagnosed based on clinical imaging, gastroscopy with biopsy, and/or cytological examination of ascites, or intraoperative findings in patients who underwent reoperation. Predictors of early recurrence were compared in patients with pT1 and pT2-4a stage tumors. Pearson's χ 2 test and Fisher's exact test were used to compare differences between categorical variables. Survival curves were constructed using the Kaplan-Meier method and compared via the log-rank test. Variables identified as potentially important for early recurrence using univariate analysis were determined by multivariate logistic regression analysis. Core tip: Few studies have assessed recurrence patterns or predictors of early recurrence after curative surgery in Chinese patients with gastric carcinoma. This study found that survival after gastric cancer recurrence was poor. Large tumor size and advanced pN stage were associated with early recurrence of tumor pT1 stage tumors. Age, pT stage, pN stage, Lauren histotype, lymphovascular invasion, intraoperative chemotherapy, and postoperative chemotherapy were independent predictors of early recurrence of pT2-4a stage tumors. RESULTS:Kang WM, Meng QB, Yu JC, Ma ZQ, Li ZT. Factors associated with early recurrence after curative surgery for gastric cancer.

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“…49 Macroscopic PC could be reduced by the use of neoadjuvant chemotherapy (NACT). 23,45 A paper published by Yano and colleagues reported a complete remission of peritoneal metastasis in 4 over 26 patients (15.4%) with PC from GC after NACT. 50 Inokuchi and colleagues showed partial response in 9 of 13 patients (69%) following NACT for PC from GC.…”

Section: Treatment and Prevention Of Peritoneal Carcinosismentioning

confidence: 99%

“…21,22 Many studies showed that polymerase chain reaction using CEA, CEA/CK20 target genes provides a greater sensitivity than peritoneal citology in detecting free cancer cells and it will assist in reducing understimated advanced GC cases allowing a better patients selection and resulting appropriate treatment combinations. 23 analysis by Kai-Deng and colleagues, 27 demonstrated the prognostic value of molecular analysis of peritoneal fluid in GC patients also in cases with negative exfoliative cytology in terms of overall survival, disease free survival and peritoneal recurrence free-survival in GC patients receiving curative treatment. Literature data clearly demonstrated the necessity to prosecute on the way to prevent the PC in AGC by increasing the power of patient selection instruments and by anticipating PC with all the necessary and effective methods, especially by administering intraperitoneal chemotherapy in all those patients at high risk for PC.…”

Section: Introductionmentioning

confidence: 99%

Advanced gastric cancer: new perspectives of treatment

et al. 2016

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The prognosis in patients with advanced gastric cancer with carcinosis remains poor with a median survival of less than one year. High rates of peritoneal recurrence of patients undergoing resection with potentially curative intent are strictly related with lymphatic spread and penetration of the serosa. To increase survival rates, during the last thirty years different strategies about screening and treatment have been tested and proposed. Early detection of occult peritoneal micrometastasis is a base step to reduce local and serosa recurrences and to offer a tailored surgical and neoadjuvant therapeutic treatment. The complete cytoreductive surgery, however, remains the cornerstone of treatment. It could be associated with different combinations of chemotherapy regimens. Adjuvant, neoadjuvant and intraperitoneal chemotherapy have been demonstrated effective in improving the survival. In the last years, a few new molecules have been introduced which enhance the effect of chemotherapy by biologically targeting its objective. Lastly the prevention of macroscopic peritoneal carcinosis in all those patients at high risk due to serosal infiltration by treating them with intraperitoneal chemotherapy has been demonstrated to be one of the future winning approaches. In patients with peritoneal carcionosis, multimodal comprehensive treatment should be mandatory, with a pivotal role of intraperitoneal chemotherapy associate to CC0 cytoreduction. Neoadjuvant chemotherapy followed by cytoreductive surgery and intraperitoneal chemotherapy gave promising results. The new molecules as monoclonal antibodies seem to improve outcomes.

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Recurrence in patients following curative resection of early gastric carcinoma

Abstract: Early gastric cancer patients, who were elderly, had lymphatic and submucosal involvement, and patients with a positive family history of cancer, tended to have a greater risk of recurrence.

Cited by 50 publications

References 21 publications

Comparison the sixth and seventh editions of the AJCC staging system for T1 gastric cancer: a long-term follow-up study of 2124 patients

Comparison the sixth and seventh editions of the AJCC staging system for T1 gastric cancer: a long-term follow-up study of 2124 patients

Factors associated with early recurrence after curative surgery for gastric cancer

Advanced gastric cancer: new perspectives of treatment

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