Recurrence of Corneal Stromal Dystrophies After Penetrating Keratoplasty

Marcon, Alexandre S.; Cohen, Elisabeth J.; Rapuano, Christopher J.; Laibson, Peter R.

doi:10.1097/00003226-200301000-00005

Cited by 80 publications

(38 citation statements)

References 10 publications

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“…7,9 In a large study performed by Pandrowala et al, 22 the recurrence rate of corneal dystrophies was 2.8% in 181 eyes after PK over a period of 6 years. In the study of Marcon et al, 23 the recurrence rate was highest in eyes with lattice dystrophy (60%) after PK and there was a clinically significant recurrence after 5 years of follow-up.…”

Section: Discussionmentioning

confidence: 87%

Deep Anterior Lamellar Keratoplasty for the Treatment of Stromal Corneal Dystrophies

Ünal

Arslan

Atalay

et al. 2013

Cornea

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Section: Discussionmentioning

confidence: 87%

Deep Anterior Lamellar Keratoplasty for the Treatment of Stromal Corneal Dystrophies

Ünal

Arslan

Atalay

et al. 2013

Cornea

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“…The BPC also supported human corneal epithelial cell growth and a human corneal stroma-derived mesenchymal stem cell population in vitro. When combined with an optimal seeding method and temporal degradation profile, cell-seeded BPCs could find additional therapeutic applications in stem cell-mediated corneal tissue regeneration for blinding conditions associated with epithelial stem cell deficiency [29] or disorders of the corneal stroma [30,31]. A major problem for stem cell delivery in the cornea has been the lack of a suitable carrier for the stem cells -one that can maintain a population of stem cells while simultaneously enabling migration of the cells or their progeny into surrounding host tissue.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Regeneration of Corneal Tissue via a Bioengineered Collagen Construct Implanted by a Nondisruptive Surgical Technique

Koulikovska

Rafat

Petrovski

et al. 2015

Tissue Engineering Part A

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Severe shortage of donor corneas for transplantation, particularly in developing countries, has prompted the advancement of bioengineered tissue alternatives. Bioengineered corneas that can withstand transplantation while maintaining transparency and compatibility with host cells, and that are additionally amenable to standardized, low-cost mass production, are sought. In this study, a bioengineered porcine construct (BPC) was developed to function as a biodegradable scaffold to promote corneal stromal regeneration by host cells. Using high purity medical-grade type I collagen, high 18% collagen content and optimized EDC-NHS crosslinker ratio, BPCs were fabricated into hydrogel corneal implants with over 90% transparency and fourfold increase in strength and stiffness compared to previous versions. Remarkably, optical transparency was achieved despite the absence of collagen fibril organization at the nanoscale. In vitro testing indicated the BPC supported confluent human epithelial and stromal-derived mesenchymal stem cell populations. With a novel femtosecond laser-assisted corneal surgical model in rabbits, cell-free BPCs were implanted in vivo in the corneal stroma of 10 rabbits over an 8 week period. In vivo, transparency of implanted corneas was maintained throughout the postoperative period, while healing occurred rapidly without inflammation and without the use of postoperative steroids. BPC implants had a 100% retention rate at 8 weeks, when host stromal cells began to migrate into implants. Direct histochemical evidence of stromal tissue regeneration was observed by means of migrated host cells producing new collagen from within the implants. This study indicates that a cost-effective BPC extracellular matrix equivalent can incorporate cells passively to initiate regenerative healing of the corneal stroma, and is compatible with human stem or organ-specific cells for future therapeutic applications as a stromal replacement for treating blinding disorders of the cornea.3

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“…Patients with LCD are therefore treated by keratoplasty to improve visual acuity after repeated PTK. The median time to simple recurrence after penetrating keratoplasty was found to be 8.4 years in one study [19]. Treatment for LCD patients thus continues over a lifetime.…”

Section: Discussionmentioning

confidence: 97%

New mode of treatment for lattice corneal dystrophy type I: corneal epithelial debridement and fibronectin eye drops

et al. 2011

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Despite the limitation of this study setting, corneal epithelial debridement followed by administration of fibronectin eye drops seems to be effective in improving visual acuity in cases of lattice corneal dystrophy type I caused by the R124C mutation of the TGFBI gene. This treatment may be one option for temporarily improving visual acuity in lattice corneal dystrophy type I and thus may delay the requirement for phototherapeutic keratoplasty or keratoplasty.

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Recurrence of Corneal Stromal Dystrophies After Penetrating Keratoplasty

Cited by 80 publications

References 10 publications

Deep Anterior Lamellar Keratoplasty for the Treatment of Stromal Corneal Dystrophies

Deep Anterior Lamellar Keratoplasty for the Treatment of Stromal Corneal Dystrophies

Enhanced Regeneration of Corneal Tissue via a Bioengineered Collagen Construct Implanted by a Nondisruptive Surgical Technique

New mode of treatment for lattice corneal dystrophy type I: corneal epithelial debridement and fibronectin eye drops

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