Recurrence of COVID-19 after recovery ? A case series in health care workers, France

Zayet, Souheil; Royer, P; Toko, Lynda; Pierron, Alix; Klopfenstein, Timothée

doi:10.1016/j.micinf.2021.104803

Cited by 10 publications

(5 citation statements)

References 18 publications

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“…On the other hand, the high number of HCWs with mild-to-moderate symptoms in our cohort could be explained by the young age of patients with no underlying comorbidities. The hypothesis that prolonged and repeated exposure to SARS-CoV-2 contributes to a higher viral load in this population has already been discussed in the literature [ 22 ], but this theory seems unlikely as exposure to infection leads to immunity in most cases. On the other hand, post-traumatic stress disorder, peritraumatic dissociation, and anxiety disorders may occur more frequently in HCWs due to the caring responsibilities in this epidemic context [ 9 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France

et al. 2021

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(1) Background. Post-COVID-19 syndrome is defined as the persistence of symptoms after confirmed SARS-CoV-2 infection. (2) Methods. ANOSVID is an observational retrospective study in Nord Franche-Comté Hospital in France that included adult COVID-19 patients confirmed by RT-PCR from 1 March 2020 to 31 May 2020. The aim was to describe patients with post-COVID-19 syndrome with persistent symptoms (PS group) and to compare them with the patients without persistent symptoms (no-PS group). (3) Results. Of the 354 COVID-19 patients, 35.9% (n = 127) reported persistence of at least one symptom after a mean of 289.1 ± 24.5 days after symptom onset. Moreover, 115 patients reported a recurrence of symptoms after recovery, and only 12 patients reported continuous symptoms. The mean age of patients was 48.6 years (19–93) ± 19.4, and 81 patients (63.8%) were female. Patients in the PS group had a longer duration of symptoms of initial acute SARS-CoV-2 infection than patients in the no-PS group (respectively, 57.1 ± 82.1 days versus 29.7 ± 42.1 days, p < 0.001). A majority of patients (n = 104, 81.9%) reported three or more symptoms. The most prevalent persistent symptoms were loss of smell (74.0%, n = 94), fatigue (53.5%, n = 68), loss of taste (31.5%, n = 40), and dyspnea (30.7%, n = 39). These were followed by pain symptoms (26.8% (n = 34), 26.0% (n = 33), 24.4% (n = 31); headache, arthralgia, and myalgia, respectively). More than half of patients reporting persistent symptoms (58%, n = 73) were healthcare workers (HCWs). Among outpatients, this population was more present in the PS group than the no-PS group ((86.6%) n = 71/82 versus (72.2%) n = 109/151, p = 0.012). Post-COVID-19 syndrome was more frequent in patients with a past history of chronic rhinosinusitis (8.7% (n = 11%) versus 1.3% (n = 3), p < 0.001). No significant difference was found regarding clinical characteristics and outcome, laboratory, imaging findings, and treatment received in the two groups. (4) Conclusions. More than a third of our COVID-19 patients presented persistent symptoms after SARS-CoV-2 infection, particularly through loss of smell, loss of taste, fatigue, and dyspnea, with a high prevalence in HCWs among COVID-19 outpatients.

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Section: Discussionmentioning

confidence: 99%

Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France

et al. 2021

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“…This is particularly important, as the reinfection of COVID-19 is not uncommon [ 6 , 7 ]. Cavanaugh and colleagues (2021) reported that among previously infected individuals, those who were not vaccinated were twice as likely to be re-infected compared to those who were fully vaccinated [ 8 ]. Another study reported that those who were unvaccinated had 2.6 and 5.3 times, respectively, higher rates of incidence and hospitalization due to COVID-19 compared with those who were fully vaccinated [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

COVID-19 Booster Vaccination Hesitancy in the United States: A Multi-Theory-Model (MTM)-Based National Assessment

et al. 2022

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Background: Despite the availability of COVID-19 vaccines and the proven benefits of vaccinations outweighing the potential risks, hesitancy to accept vaccines and additional doses remains a persistent problem. Therefore, the purpose of the study was to investigate hesitancy, confidence, literacy, and the role of the multi-theory model (MTM) constructs in COVID-19 booster uptake. Methods: This cross-sectional study utilized a 52-item psychometric valid web-based survey conducted during the month of October 2021 to recruit a nationally representative sample of U.S. adults. Univariate, bivariate, and multivariate statistical tests were used to analyze the data. Results: Among the booster hesitant group (n = 209, 41.7%), a significantly larger proportion of respondents were unvaccinated with the primary series (43.5% vs. 11%, p < 0.001), were among 18–44 years age group (51.2% vs. 31.8%, p < 0.001), single or never married (33.0% vs. 24.3%, p = 0.04), had lower education with some high school (6.2% vs. 2.4%, p = 0.03), and identified themselves as Republicans (31.6% vs. 20.5%, p = 0.01). The hesitant group had lower mean scores of vaccine literacy, and vaccine confidence, and had 19% lower odds of behavioral confidence than their non-hesitant counterparts (adjusted odds ratio = 0.81, 95% CI: 0.71–0.92). Conclusions: The findings of this study underscore the need of raising public awareness through effective multi-theory-model-based communication campaigns.

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“…The main symptoms reported were asthenia, chest pain, cough and dysgeusia (n = 8, n = 5, n = 4, n = 4, respectively). However, the cases of resurgence of symptoms described in the literature remain rare and present very variable clinical characteristics, ranging from simple flu-like syndrome [47,48] to ARDS leading to death [49]. In the literature the resurgence seems to be related to viral reactivation [47][48][49][50].…”

Section: Discussionmentioning

confidence: 99%

“…However, the cases of resurgence of symptoms described in the literature remain rare and present very variable clinical characteristics, ranging from simple flu-like syndrome [47,48] to ARDS leading to death [49]. In the literature the resurgence seems to be related to viral reactivation [47][48][49][50]. In COVEVOL it was based on clinical data, by self-reported symptoms, and not virological data.…”

Section: Discussionmentioning

confidence: 99%

COVEVOL: Natural Evolution at 6 Months of COVID-19

Messin

Puyraveau

Benabdallah

et al. 2021

Viruses

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Many studies have investigated post-COVID symptoms, but the predictors of symptom persistence remain unknown. The objective was to describe the natural course of the disease at 6 months and to identify possible factors favoring the resurgence or persistence of these symptoms. COVEVOL is a retrospective observational descriptive study of 74 patients. All patients with positive SARS-CoV-2 PCR from March 2020 were included. We compared a group with symptom persistence (PS group) with another group without symptom persistence (no-PS group). Fifty-three out of seventy-four patients (71.62%) described at least one persistent symptom at 6 months of SARS-CoV-2 infection. In the PS group, 56.6% were women and the average age was 54.7 years old [21-89.2] ±16.9. The main symptoms were asthenia (56.6%, n = 30), dyspnea (34%, n = 18), anxiety (32.1% n = 17), anosmia (24.5%, n = 13) and agueusia (15.1% n = 8). Ten patients (13.51%) presented a resurgence in symptoms. Patients in the PS group were older (p = 0.0048), had a higher BMI (p = 0.0071), and were more frequently hospitalized (p = 0.0359) compared to the no-PS group. Odynophagia and nasal obstruction were less present in the inaugural symptoms of COVID-19 in the PS group (p = 0.0202 and p = 0.0332). Persistent post-COVID syndromes are common and identification of contributing factors is necessary for understanding this phenomenon and appropriate management.

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Recurrence of COVID-19 after recovery ? A case series in health care workers, France

Abstract: We describe 3 cases of coronavirus disease 2019 in health care workers in France involving presumed clinical and microbiological recurrence after recovery. All patients were immunocompetent with clinical mild form. These cases highlight the possibility of coronavirus disease–recurrence.

Cited by 10 publications

References 18 publications

Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France

Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France

COVID-19 Booster Vaccination Hesitancy in the United States: A Multi-Theory-Model (MTM)-Based National Assessment

COVEVOL: Natural Evolution at 6 Months of COVID-19

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