Recurrence of hepatocellular cancer after liver transplantation: The role of primary resection and salvage transplantation in East and West

Lai, Quirino; Avolio, Alfonso Wolfango; Lerut, Jan; Singh, Gurusharan; Chan, See Ching; Berloco, P.B.; Tisone, Giuseppe; Agnes, Salvatore; Chok, Kenneth S. H.; Sharr, WW; Rossi, Massimo; Manzia, Tommaso Maria; Lo, Chung Mau

doi:10.1016/j.jhep.2012.06.033

Cited by 53 publications

(39 citation statements)

References 37 publications

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“…Although higher AFP level 22, 23, larger tumor size 24, 25, venous infiltration 22, 23, advanced pTNM stage 26, beyond UCSF 27 or Milan 23 criteria are normally applied as prognostic markers for tumor recurrence after liver resection, these factors were not identified as independent predictors for overall survival after liver transplantation in our study. It might be attributed to the different mechanisms of tumor recurrence between liver transplantation and resection.…”

Section: Discussioncontrasting

confidence: 62%

The Clinical Significance and Potential Therapeutic Role of GPx3 in Tumor Recurrence after Liver Transplantation

Xiang

Shao

et al. 2016

Theranostics

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Background and Aims: Our previous study showed that small-for-size liver graft may provide favorable micro-environment for tumor growth. GPx3, an anti-oxidant, not only attenuates oxidative stress, but also suppresses liver tumor growth in our recent study. Here, we aimed to characterize the clinical significance and explore the functional role of GPx3 in HCC recurrence after liver transplantation.Methods: To explore the association between GPx3 expression and HCC invasiveness, a rat orthotopic liver transplantation model with tumor development was established. To investigate the clinical relevance of GPx3, 105 HCC patients who underwent liver transplantation were recruited. The suppressive role of GPx3 in HCC cells was studied using wound healing, Matrigel invasion assay and lung metastasis model. The real-time intravital imaging system was applied to directly visualize the tumor cells invasion in a living animal. The underlying mechanism was further explored.Results: GPx3 was identified as a down-regulated protein in small-for-size liver graft and significantly associated with invasive phenotype of tumor growth in a rat model. Plasma GPx3 was significantly lower in small-for-size graft group post-transplantation (day1: 33 vs 1147; day3: 3209 vs 4459; day7: 303 vs 2506; mU/mL, P<0.05) in rat model. Clinically, the plasma GPx3 was significantly lower in the recipients with HCC recurrence post-transplantation (day1: 4.16 vs 8.99 µg/mL, P<0.001; day7: 3.86 vs 9.99 µg/mL, P<0.001). Furthermore, lower plasma GPx3 was identified as an independent predictor (HR=4.528, P=0.046) for poor overall survival post-transplantation. Over-expression of GPx3 significantly suppressed migration, invasiveness and metastasis of HCC cells. Real-time intravital imaging showed that GPx3 significantly suppressed HCC invasiveness in a live animal. GPx3 suppressed the tumor invasiveness through inhibition of JNK-cJun-MMP2 pathway.Conclusion: GPx3 may possess prognostic and therapeutic value for HCC patients after liver transplantation.

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Section: Discussioncontrasting

confidence: 62%

The Clinical Significance and Potential Therapeutic Role of GPx3 in Tumor Recurrence after Liver Transplantation

Xiang

Shao

et al. 2016

Theranostics

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“…Since HCC relapses after liver transplant can be very high (about 50% -5 years in patients with liver transplant after HCC resection 9 ) and serum HBsAg recurrence is accociated with HCC recurrence (7/8 patients, 87.5% 10 ) one possibility is to use HBV-TCR T cells not only as a therapy but as a prophylactic treatment to prevent HCC seeding in liver-transplanted patients with HBsAg positive HCC. In animal models HCC seeding was blocked with the use of HBV-TCR-T cells expressing transiently TCR trough mRNA electroporation.…”

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confidence: 99%

T cell receptor-therapy in HBV-related hepatocellularcarcinoma

et al. 2015

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“…Besides this, the sample population may not be fully extrapolated to the whole HCC population worldwide. Numerous literatures have shown that the occurrence and progression of HCC are quite different between east and west populations (Lai et al, 2012). Our study cohort reflected more the conditions of HCC patients in the East Asian area.…”

Section: Discussionmentioning

confidence: 89%

Comparison of laparoscopic hepatectomy, percutaneous radiofrequency ablation and open hepatectomy in the treatment of small hepatocellular carcinoma

Lai

Jin

Liang

et al. 2016

J. Zhejiang Univ. Sci. B

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Abstract:Objective: Three mainstream techniques-laparoscopic hepatectomy (LH), percutaneous radiofrequency ablation (pRFA), and open hepatectomy (OH)-were compared in this study, in terms of their efficacies in the treatment of small hepatocellular carcinoma (HCC). Methods: A comparative study was performed within a total of 94 patients diagnosed with small HCC in our hospital from 2005 to 2010, who underwent LH (28), RFA (33), or OH (33). They had either a single tumor lesion of less than 5 cm or up to three nodules with diameters of less than 3 cm each. Outcomes were carefully evaluated throughout a 3-year follow-up interval and statistically interpreted. Results: The pRFA group had a significantly lower disease-free survival rate compared with the two surgical groups (P=0.001) and significantly shorter overall survival (P=0.005), while the LH group and the OH group had no difference in survival results. For patients younger than 60 years old, surgical approaches offered a better long-term overall survival prognosis (P=0.008). There were no statistically significant differences among the three groups in overall survival for elderly patients (P=0.104). Conclusions: Among patients with small HCC, LH may provide better curative effects than pRFA without increasing complication rates. pRFA leads to faster recurrence than surgical resections. LH has similar therapeutic effects to OH and causes less trauma. For patients younger than 60 years old, LH may be the best curative treatment. Elderly patients may choose either surgery or pRFA.

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Recurrence of hepatocellular cancer after liver transplantation: The role of primary resection and salvage transplantation in East and West

Cited by 53 publications

References 37 publications

The Clinical Significance and Potential Therapeutic Role of GPx3 in Tumor Recurrence after Liver Transplantation

The Clinical Significance and Potential Therapeutic Role of GPx3 in Tumor Recurrence after Liver Transplantation

T cell receptor-therapy in HBV-related hepatocellularcarcinoma

Comparison of laparoscopic hepatectomy, percutaneous radiofrequency ablation and open hepatectomy in the treatment of small hepatocellular carcinoma

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