Recurrence of Intravenous Talc Granulomatosis following Single Lung Transplantation

Cook, R.C.M.; Fradet, Guy; English, John; Soós, J; Müller, Néstor L.; Connolly, Thomas; Levy, Robert D.

doi:10.1155/1998/959750

Cited by 21 publications

(12 citation statements)

References 9 publications

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“…Moreover, most of the subjects (83%) reported use of intravenous route with multiple injections per day (up to 28 times a day with a dosage of up to 2,800 mg/day). This considerable number of MPH injections has also been reported by other authors [20,32] and may lead to complications related to parenteral injection of dissolved MPH tablets such as localized or generalized infection, pulmonary granulomatous disease or retinopathy [33][34][35][36][37] . In addition, our (35) study outlined other health problems related to MPH abuse, like cardiovascular events, weight loss and/or psychiatric adverse events.…”

Section: Discussionsupporting

confidence: 55%

Patterns of Methylphenidate Use and Assessment of Its Abuse among the General Population and Individuals with Drug Dependence

Frauger¹,

Amaslidou²,

Spadari³

et al. 2015

Eur Addict Res

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Purpose: The aim of this study was to describe the extent of methylphenidate (MPH) abuse and characterize its patterns by following several cases involving intravenous administration of crushed MPH tablets. Methods: First, a drug reimbursement database (covering 4 million inhabitants) was explored to assess the magnitude of MPH abuse among the general population, and second, a specific study based on individuals with drug dependence was performed to describe abusers' characteristics (n = 64), patterns of abuse and clinical implications. Results: From 2005 to 2011, the number of patients who were dispensed MPH at least once increased by 166%. The patients with ‘deviant' patterns of MPH consumption were mainly male adults with opiate maintenance treatment reimbursements. MPH abusers had precarious living conditions. Half of them consumed MPH daily by intravenous route and reported amphetamine-like effects (cardiovascular events, weight loss, psychiatric adverse events). Conclusion: Given the increase of MPH use, it is important to warn the scientific community about possible MPH abuse, especially in individuals with drug dependence. This study has facilitated public health intervention and dissemination of information related to MPH abuse among health care professionals at local and national levels.

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Section: Discussionsupporting

confidence: 55%

Patterns of Methylphenidate Use and Assessment of Its Abuse among the General Population and Individuals with Drug Dependence

Frauger¹,

Amaslidou²,

Spadari³

et al. 2015

Eur Addict Res

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“…Treatment with corticosteroids has been attempted, with gradual or temporary improvement, although there is a risk of relapse after cessation [241]. A number of patients with pulmonary disease due to injection of oral medications have undergone lung transplantation [242]. However, recurrent and ongoing i.v.…”

Section: Treatmentmentioning

confidence: 99%

“…However, recurrent and ongoing i.v. drug abuse, leading to a histiocytic reaction in the transplanted lung, should raise substantial concerns on performing lung transplantation in cases of substance abuse [242].…”

Section: Treatmentmentioning

confidence: 99%

Nonthrombotic pulmonary embolism

Jorens¹,

Marck²,

Snoeckx³

et al. 2009

Eur Respir J

162

127

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Nonthrombotic pulmonary embolism (NTPE) is defined as embolisation to the pulmonary circulation of different cell types (adipocytes, haematopoietic, amniotic, trophoblastic or tumour), bacteria, fungi, foreign material or gas. The purpose of this article is to describe the clinical signs, pathogenesis, diagnosis and treatment of the different NTPE subtypes.The complex and diverse pathogenesis of different subtypes of emboli is subject to continuing speculation and is certainly far more complex than ''simple'' mechanical obstruction after embolisation of vascular thrombi. Nonthrombotic emboli may also lead to a severe inflammatory reaction both in the systemic and pulmonary circulation, as well as in the lung.NTPE presents a formidable diagnostic challenge, as the condition often presents with very unusual and peculiar clinical signs that are frequently overlooked. They range from very dramatic acute presentations such as acute respiratory distress syndrome to signs observed late in the disease course. Pathological observations play a key role in the exact diagnosis, and sometimes carefully aspirated blood from the pulmonary artery or specific staining of cells recovered from bronchoalveolar lavage fluid may be helpful. Frequently, lung biopsies revealing severe granulomatous reaction or unfortunate post-mortem pathological investigations of pulmonary tissue are necessary to confirm the diagnosis. Here, we also aim to familiarise the reader with the atypical radiological features of NTPE. Thin-section computed tomography of the lungs showing peculiar radiographic findings, such as a feeding vessel, the so-called tree-in-bud pattern or the appearance of micronodules distributed at the termination of bronchovascular bundles, may be observed in certain forms of NTPE.Increased awareness of NTPE as an underestimated cause of acute and chronic embolism, which may result in acute and chronic pulmonary hypertension, is needed. Despite the fact that detailed descriptions of several forms of NTPE have existed for nearly 100 years, well-designed trials have never been performed to evaluate therapy in the different subsets of these patients.

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“…High-resolution computed tomography may reveal ground-glass attenuation, diffuse micronodules, conglomerate masses, and lower lobe panacinar emphysema [4]. Panlobular emphysema is an uncommon but well described complication of intravenous injection of oral medications [1][2][3][4][5][6]. Methylphenidate and methadone are the most common drugs used but several others have been reported [1,2,5].…”

Section: Discussionmentioning

confidence: 99%

“…Lung transplantation can be an alternative in some patients but recurrence has been reported in one patient [6].…”

Section: Discussionmentioning

confidence: 99%

A 44-yr-old male with progressive dyspnoea and dry cough

Genta¹,

Valeri²,

Kairalla³

et al. 2002

Eur Respir J

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Recurrence of Intravenous Talc Granulomatosis following Single Lung Transplantation

Cited by 21 publications

References 9 publications

Patterns of Methylphenidate Use and Assessment of Its Abuse among the General Population and Individuals with Drug Dependence

Patterns of Methylphenidate Use and Assessment of Its Abuse among the General Population and Individuals with Drug Dependence

Nonthrombotic pulmonary embolism

A 44-yr-old male with progressive dyspnoea and dry cough

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