Recurrence of Invasive Micropapillary Carcinoma of the Breast with Different Ultrasound Features according to Lesion Site: Case Report

Mizushima, Yasuko; Yamaguchi, Rin; Yokoyama, Tetsuo; Ogo, Etsuyo; Nakashima, Osamu

doi:10.2739/kurumemedj.58.81

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Metastasis to lymph nodes can play an important role as a prognostic factor, particularly in several types of breast cancers including invasive micropapillary cancers (9)(10)(11). The number of nodal involved can also have prognostic value (12)(13)(14). In the current study, we noticed a higher rate of metastasis to lymph nodes in patients with IMPC compared to IDC-NOS.…”

Section: Discussionsupporting

confidence: 54%

Evaluation of Lymph Node Metastasis in Invasive Micropapillary Breast Carcinoma and Other Its Related Variables

et al. 2022

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Background: The rate of lymph node metastasis in patients with invasive micropapillary carcinoma (IMPC) could be considered a critical prognostic factor whose measurement may enhance therapeutic outcomes in these patients. Objectives: The current study aims at determining the rate of lymph node involvement in IMPC patients and comparing it with that of invasive ductal carcinoma, not otherwise specified (IDC-NOS) patients. Methods: In this case-control study, a total of 124 participated, including 61 patients with IMPC and 63 patients with IDC-NOS. The rate of lymph node metastasis and its possible connection with the patient's age, tumor size, grade and focality, lymphovascular invasion, and proportion of micropapillary component were determined in patients with IMPC and compared to that of IDC-NOS patients. Results: Lymph node involvement was detected in 80.3% of patients with IMPC, which is significantly higher compared to patients with IDC-NOS. No significant correlation was found between lymph node metastasis and the patients’ age, tumor size, and focality in both IMPC and IDC-NOS groups. Furthermore, no significant relationship was observed between lymph node metastasis and tumor grade in IMPC, while metastasis to lymph nodes was directly correlated with higher tumor grades of NOS type. Moreover, in both types of cancer, lymph node metastasis was significantly associated with lymphovascular invasion. In patients with IMPC, no statistically significant relevance was observed between lymph node metastasis and the percentage of micropapillary components. Conclusions: According to the results of this study, patients with IMPC had a significantly higher rate of lymph node involvement compared to IDC-NOS. Hence, the rate of lymph node involvement could be used as a prognostic factor in these patients.

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Section: Discussionsupporting

confidence: 54%

Evaluation of Lymph Node Metastasis in Invasive Micropapillary Breast Carcinoma and Other Its Related Variables

et al. 2022

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“…To date, the majority of studies have focused on the pathological features and ultrasonographic findings of IMPC (8,9). In previous reports, most IMPCs presented as an irregular mass with a high density and a non-circumscribed margin on the mammography, and as an irregular spiculated mass on magnetic resonance imaging (MRI) (10)(11)(12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

MRI and the pathology of breast invasive micropapillary carcinoma

Chen

Yao

et al. 2020

Oncol Lett

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Diagnosis of breast invasive micropapillary carcinoma (IMPC) before surgery is of great value for determining the optimal treatment strategy. The aim of the present study was to investigate the magnetic resonance imaging (MRI) and pathological features of IMPC. MRI features of IMPC were characterized in relation to the patients' clinicopathological features. Clinical manifestations, mammography results and/or MRI findings of patients with IMPC were retrospectively analyzed. Parameters included morphology, plain T2-weighted imaging (T2WI) signal intensity, the apparent diffusion coefficient (ADC), the internal enhancement mode, early enhancement rates and time-intensity curve (TIC) types during dynamic enhanced scanning. A total of 10 lesions were detected by MRI in eight patients, with one case having three lesions with the mean diameter of 34.44 mm. In plain T2WI scanning, the lesions appeared inhomogeneous with a moderate or high signal intensity. When the b value was 800 sec/mm 2 , the average ADC value was 0.823±0.12x10-3 mm 2 /sec. A total of four cases exhibited mass-like enhancement, including an oval rim in one case (three lesions), irregular inhomogeneous enhancement in two cases and irregular uniform enhancement in one case. The margins were clear in one case (three lesions), irregular in two cases and spiculate in one case. Among the four cases with non-mass enhancement, the distribution was focal in two cases, linear in one case and regional in one case, and the internal enhancement mode was cluster-like in one case, heterogeneous in one case and uniform in two cases. The average early enhancement rate was 116.96±45.26%. TICs of type III were observed in all cases. In conclusion, MRI of IMPC demonstrated typical features of malignant tumors and lymphatic vessel infiltration, suggesting that MRI may exhibit guiding significance for the diagnosis and treatment planning of IMPC.

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Micropapillary Breast Carcinoma: From Molecular Pathogenesis to Prognosis

GI¹,

Tchabashvili²,

Mulita³

et al. 2022

BCTT

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Invasive micropapillary carcinoma (IMPC) of the breast is an infrequent type of breast cancer often discussed for its potency for lymphovascular invasion and difficulty in accurate imaging estimation. Micropapillary carcinomas are noted to be present as larger tumors, of higher histological grade and a notably higher percentage of disease-positive lymph nodes. Hormonal and HER-2 positivity in IMPC is also commoner when compared to other NST carcinomas. IMPC occurs either as a pure form or more often as a component of mixed Non-Specific Type (NST) carcinoma. The latest data suggest that despite having comparable survival rates to other histological subtypes of breast carcinoma, effective surgical treatment often requires extended surgical margins and vigilant preoperative axillary staging due to an increased incidence of lymph node invasion, and locoregional recurrence. Moreover, the presence of micropapillary in situ components within tumors also seems to alter tumor aggression and influence the nodal disease stage. In this review, we present an overview of the current literature of micropapillary carcinoma of the breast from biology to prognosis, focusing on biological differences and treatment.

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Recurrence of Invasive Micropapillary Carcinoma of the Breast with Different Ultrasound Features according to Lesion Site: Case Report

Cited by 3 publications

References 10 publications

Evaluation of Lymph Node Metastasis in Invasive Micropapillary Breast Carcinoma and Other Its Related Variables

Evaluation of Lymph Node Metastasis in Invasive Micropapillary Breast Carcinoma and Other Its Related Variables

MRI and the pathology of breast invasive micropapillary carcinoma

Micropapillary Breast Carcinoma: From Molecular Pathogenesis to Prognosis

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