Recurrence of Thyroid Cancer: From Papillary to Anaplastic

Abstract

Recurrent thyroid cancer often presents much more aggressively than the initial presentation. We present a case of a 50-year-old female, previously diagnosed and treated for papillary thyroid cancer, who subsequently developed a rapidly growing anaplastic thyroid cancer. This paper provides a discussion of anaplastic thyroid cancer in comparison to papillary cancer.

Metastatic Papillary Thyroid Carcinoma with Multifocal Synchronous Transformation to Anaplastic Thyroid Carcinoma

“…While the transformation of papillary thyroid carcinoma to the more aggressive anaplastic carcinoma represents a well-known occurrence, the transformation of metastatic PTC in a distant location (i.e., a location other than the usually seen neck and cervical lymph node metastases) represents an uncommon finding, which typically has been presented in the literature as a case report [ 8 ]. Even rarer is the finding of multifocal transformation of PTC to anaplastic carcinoma in distant locations (the lung and adrenal gland in this case) with only a few cases described [ 4 , 9 , 10 ]. The diagnosis of papillary thyroid carcinoma can become challenging, that is, in its differentiation from a primary lung carcinoma, when the thyroglobulin immunohistochemical stain is negative.…”

BRAF-positive paucicellular variant of anaplastic carcinoma in the presence of tall cell variant papillary thyroid cancer

“…Анапластическая карцинома -редкая опухоль щитовидной железы, составляет 1-5% всех злокачественных тиреоидных образований [5]. Выделяют несколько гистологических вариантов: веретеноклеточный, гигантоклеточный, сквамоидный, малоклеточный, рабдоидный, ангиоматоидный, лимфоэпителиоподобный, карциносаркоматозный, железисто-плоскоклеточный [6,9].…”