Recurrence rate and shift in histopathological differentiation of oral squamous cell carcinoma – A long-term retrospective study over a period of 13.5 years

Ermer, Michael Andreas; Kirsch, Karsten; Bittermann, Gido; Fretwurst, Tobias; Vach, Kirstin; Metzger, Marc Christian

doi:10.1016/j.jcms.2015.05.011

Cited by 26 publications

(16 citation statements)

References 59 publications

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“…We found a strong significant correlation of grading with locoregional recurrence of SCC of the buccal mucosa ( P = .001). The significant role of grading for metastasis, resection margins, and survival rates have been reported in a variety of studies . However, our multivariate analysis could not confirm grading as an independent risk factor ( P = .552).…”

Section: Discussioncontrasting

confidence: 72%

“…The significant role of grading for metastasis, resection margins, and survival rates have been reported in a variety of studies. [15][16][17] However, our multivariate analysis could not confirm grading as an independent risk factor (P 5 .552). We assume that this might be due to the relatively low number of patients in the subgroups, as 65 were classified as G2, 8 as G1, and 22 as G3.…”

Section: Discussioncontrasting

confidence: 62%

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Importance of lymph node ratio for locoregional recurrence of squamous cell carcinoma of the buccal mucosa

et al. 2017

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Section: Discussioncontrasting

confidence: 72%

Section: Discussioncontrasting

confidence: 62%

Importance of lymph node ratio for locoregional recurrence of squamous cell carcinoma of the buccal mucosa

et al. 2017

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“…1 Studies on the clinical pathology of oral cancer have shown that late-stage oral cancer (T3/T4) has a significantly higher recurrence rate than an early stage (T1/T2) and is related to incidence of secondary metastasis. 2,3 Unfortunately, oral squamous cell carcinoma (OSCC) is usually not detected until advanced stages, which may help to explain the high mortality rate and poor overall survival. 4 Although a number of neutralization antibodies and tyrosine kinase inhibitors for the epidermal growth factor receptor (EGFR) signaling pathway have been developed, 5 the only approved treatment for advance stage OSCC is the anti-EGFR monoclonal antibody cetuximab.…”

mentioning

confidence: 99%

ALPK1 Expression Is Associated with Lymph Node Metastasis and Tumor Growth in Oral Squamous Cell Carcinoma Patients

Chen

Hua

Hsu

et al. 2019

The American Journal of Pathology

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Oral squamous cell carcinoma (OSCC) is the most common malignant cancer, with high mortality rates in advanced stages. Recent studies have shown that the expression of ALPK1 mRNA and its inhibitory differentiation function are associated with cancer progression. However, the expression and clinicopathologic features of ALPK1 in OSCC remain unexplored. Herein, the authors investigated the expression patterns of ALPK1 in 39 matched OSCC patients and examined the relationship between ALPK1 protein expression and clinicopathologic factors using immunohistochemical scores. Using Western blot analysis, ALPK1 expression was found to be significantly higher in tumor tissues than that in nontumor tissues. Through an immunoreactive scoring system, a significantly higher number of advanced-stage tumor size T4 and lymph node metastasis N2 exhibited higher ALPK1 expression levels than that exhibited by T1/T2/T3 tumors and N0/N1. In addition, ALPK1 protein expression was aberrant in malignant oral cancer cell lines compared with that in pre-malignant oral epithelial cells, whereas minimal expression was observed in normal oral epithelial cells. Knockdown of ALPK1 resulted in a significant reduction in cell growth, migration, and invasion capacity in vitro. Consequently, expression of N-cadherin and vimentin decreased in ALPK1-deficient cells. Thus, these results suggest that ALPK1 serves as a potential biomarker and target for OSCC development in late stages.

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“…After curative intended surgery and appropriate adjuvant therapy, recurrence rates of up to 47% have been reported (González‐García, Naval‐Gías, Román‐Romero, Sastre‐Pérez, & Rodríguez‐Campo, 2009; Safi et al., 2017; Shinn et al., 2018; Weckx et al., 2019; Yanamoto et al., 2012). The 5‐year overall survival decreases from 70% to 30% in case of a relapse (Camisasca et al., 2011; Ermer et al., 2015; Safi et al., 2017; Vázquez‐Mahía et al., 2012). Several explanations have been described for this poor prognosis of recurrent disease, such as a depletion of therapeutic options after combination therapy, a more aggressive tumour biology and an impact of the previous treatment on the patient's general condition (González‐García et al., 2009).…”

Section: Introductionmentioning

confidence: 99%

Survival outcomes after surgical treatment of oral squamous cell carcinoma

et al. 2020

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Objective To identify the clinicopathological parameters that influence survival in patients with oral squamous cell carcinoma, in order to allow for the development of individualized surveillance programmes and reduce the delay in diagnosis of recurrence. Materials and Methods Retrospective chart review of 553 patients with a treatment‐naïve primary oral squamous cell carcinoma, who underwent primarily curative intended surgery. Exclusion criteria were neoadjuvant radio(chemo)therapy, follow‐up < 1 year, perioperative death, inoperable disease, synchronous multiple malignancies and inadequate information on clinicopathological parameters. Results The clinicopathological factors that influence overall survival, disease‐free survival and locoregional control were calculated. In the multivariate survival analysis, the occurrence of recurrence, presence of extracapsular spread, T‐ and N‐classification were shown to be independent risk factors for overall survival. Conclusion The identification of these risk factors can lead to the development of individualized follow‐up programmes based on risk stratification. This allows for the earliest possible diagnosis of relapse which is essential to offer the patient a realistic second treatment chance and to improve survival rates.

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Recurrence rate and shift in histopathological differentiation of oral squamous cell carcinoma – A long-term retrospective study over a period of 13.5 years

Cited by 26 publications

References 59 publications

Importance of lymph node ratio for locoregional recurrence of squamous cell carcinoma of the buccal mucosa

Importance of lymph node ratio for locoregional recurrence of squamous cell carcinoma of the buccal mucosa

ALPK1 Expression Is Associated with Lymph Node Metastasis and Tumor Growth in Oral Squamous Cell Carcinoma Patients

Survival outcomes after surgical treatment of oral squamous cell carcinoma

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